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New role for the JNK protein
Date:7/14/2010

problems push JNK to halt the process at certain 'checkpoints.' If all systems look good, the cell cycle progresses. If not, minor damage is fixed or, if beyond repair, the whole process is scrapped.

"Certain situations where JNK is hyperactive, as seen in some human tumors, might also influence the cell cycle and promote genomic instability," said Dr. Ronai. "Our laboratory is now assessing this possibility using a mouse model that was engineered based on these new discoveries."


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Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

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