Navigation Links
New research traces evolutionary path of multidrug-resistant strep bacteria
Date:1/28/2011

e importantly, the findings provide evidence that the mechanism of genetic change in S. pneumoniae is primarily not through acquisition of point mutations but more often 88 percent of the time through genetic recombination.

"The phenomenon of genetic transformation, which led Oswald Avery and his Rockefeller colleagues in 1944 to identify DNA as the genetic material, is the very process that Streptococcus pneumoniae uses during evolution in its real in vivo environment," says Tomasz.

Other phenomena first identified in the laboratory also appear in stages of pneumococcal evolution in vivo. For instance, at least some of the recombination changes observed among the clinical isolates seem to use the "competence" system, a DNA uptake mechanism induced by a specific bacterial quorum sensing agent first detected by Tomasz and colleagues in laboratory experiments. Also, the mechanism of penicillin resistance, first identified by Tomasz and colleagues in the 1980s as changes in the affinity of penicillin target proteins known as penicillin binding proteins, or PBPs, is shown to involve the borrowing of genes from other bacteria, a finding previously documented in studies of individual penicillin resistant isolates.

"Perhaps the most fascinating part of the research is the description of how rapidly this clone has responded to massive in vivo interventions in the clinical environment, such as the introduction of penicillin and other antibiotics and more recently the introduction of conjugate anti-pneumococcal vaccines," says Tomasz. "These vaccines are directed against the most abundant serotypes of this bacterium, which are carried in the nasopharynx of children and which cause invasive disease."

"This research also demonstrates the importance of close collaborations between groups like the Sanger Laboratory, with expertise in high resolution genomic analysis, and laboratories that can provide carefully characterized c
'/>"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
2. Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
3. Researchers identify biomarkers of poor outcomes in preemies
4. Research suggests HIV causes rapid aging in key infection-fighting cells
5. President Obama calls for increased investment in science, including biomedical research
6. Researchers register new species using DNA-based description
7. 23andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee
8. Purdue team creates engineered organ model for breast cancer research
9. Blue crab research may help Chesapeake Bay watermen improve soft shell harvest
10. Research into synthetic antibodies offers hope for new diagnostics
11. ASM Biodefense and Emerging Diseases Research Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... of Health will award funds to support the next ... to improve ways of predicting drug safety and effectiveness. ... 3-D human tissue chips and combine them into an ... the human body. Led by the National Center for ... institutions at $17 million in 2014 with additional support ...
(Date:9/23/2014)... on insects to predict how climate change will affect ... for the first time that insects, fear of their ... they grow. , "In other words, it,s less about ... shape the growth, survival and distribution of insects." says ... Arctic postdoctoral researcher at Dartmouth. , The study ...
(Date:9/23/2014)... scientists who are fighting a cyberwar against cancer finds ... powerful ally. , "Recent research has found that cancer ... system, and we studied the interplay between cancer and ... the tables on cancer," said Rice University,s Eshel Ben-Jacob, ... Early Edition of the Proceedings of the National ...
Breaking Biology News(10 mins):NIH funds next phase of Tissue Chip for Drug Screening program 2NIH funds next phase of Tissue Chip for Drug Screening program 3NIH funds next phase of Tissue Chip for Drug Screening program 4Insects' fear limits boost from climate change, Dartmouth study shows 2Immune system is key ally in cyberwar against cancer 2Immune system is key ally in cyberwar against cancer 3
... A component of DNA that can both stimulate ... may hold hope for treating cancer and infection, Medical ... of CpG increase inflammation, part of the body,s way ... increasing expression of the enzyme indoleamine 2,3 dioxygenase, or ...
... A new study by researchers at Princeton University,s Woodrow ... that global climate change may lead to the retreat ... States, which could create unprecedented ecological restoration opportunities across ... time, global warming may enable other invasive plants to ...
... a surprising link between brain iron levels and ... from autism to major depression., Appearing in the ... this week, the study by Randy Blakely, ... a powerful in silico approach for discovering novel ...
Cached Biology News:DNA component can stimulate and suppress the immune response 2Climate change's impact on invasive plants in Western US may create restoration opportunities 2Climate change's impact on invasive plants in Western US may create restoration opportunities 3Climate change's impact on invasive plants in Western US may create restoration opportunities 4Researchers iron out new role for serotonin 2
(Date:9/23/2014)... CLARA, Calif. , Sept. 23, 2014 ... institution in India devoted to genome-based ... of Biomedical Genomics (NIBMG) is taking a bite out ... common cancer among males in India ... object storage solutions from DataDirect Networks (DDN). , To ...
(Date:9/23/2014)... September 23, 2014 Cambridge Semantics, the ... Web technology, was named in the recent ‘Hype Cycle ... , The report details key insights pertaining to ... According to Gartner analysts Michael Shanler and Stephen Davies, ... activities, expose complex relationships with scientific stakeholders, and support ...
(Date:9/23/2014)... 2014 Texas Fertility Center (TFC) announces ... Austin, expanding a Central Texas footprint that includes Round ... satellite office for the region’s most established practice will ... South Austin, Buda, Kyle and San Marcos communities. ... treatment directly to individuals and couples living in and ...
(Date:9/23/2014)... Albany, New York (PRWEB) September 23, 2014 ... advocates from around the globe will convene ... 11th International Conference, to be held October ... latest in evidence-based research and practice in ... includes physicians, scientists, researchers, nurses, psychologists, nutritionists, ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5Cambridge Semantics Identified in Gartner’s ‘Hype Cycle for Life Sciences 2014’ Report 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3
... N.J. , June 16 Soligenix, Inc. (OTC Bulletin ... today that it has entered into common stock purchase agreements with ... Soligenix,s North American commercial partner, Sigma-Tau Pharmaceuticals, Inc., participated in this ... , ...
... ... has released two new boards based on the Altera Stratix® IV 820 devices. These ... and prototype their own products. , ... Richardson, Texas (PRWEB) June 16, 2010 -- IRIS Technologies Inc. ( www.iris-technologies.net ...
... ... METTLER TOLEDO has announced the release of iC ... chemical reactions by automatically developing a kinetic model that describes the ... reaction. The kinetic model can be used to simulate the effect ...
Cached Biology Technology:Soligenix Announces Private Equity Financing of $5.16 Million With Its Partner Sigma-Tau and Other Institutional Investors 2Soligenix Announces Private Equity Financing of $5.16 Million With Its Partner Sigma-Tau and Other Institutional Investors 3Soligenix Announces Private Equity Financing of $5.16 Million With Its Partner Sigma-Tau and Other Institutional Investors 4IRIS Technologies Inc. Launches Two New Stratix IV FPGA-Based Boards 2IRIS Technologies Inc. Launches Two New Stratix IV FPGA-Based Boards 3A Faster Way to Understand and Optimize your Chemistry 2
... ultra-compact pump available in single head (T2-04 SH) ... use in portable air and gas applications. Delivering ... well in environments where DC operation, high performance, ... critical., Offers ultra-compact size, long life, and ...
... and ballscrew technologies, the XRS ... that include all the necessary ... , XY and XYZ ... cabling for power, signals, and ...
... as building blocks, Parker can create ... solutions that are ideal for pick-and-place ... ,system, Parker can also integrate pneumatic ... and ,guarding., Standard or custom ...
Normal Hamster Serum...
Biology Products: