Navigation Links
New research traces evolutionary path of multidrug-resistant strep bacteria
Date:1/28/2011

e importantly, the findings provide evidence that the mechanism of genetic change in S. pneumoniae is primarily not through acquisition of point mutations but more often 88 percent of the time through genetic recombination.

"The phenomenon of genetic transformation, which led Oswald Avery and his Rockefeller colleagues in 1944 to identify DNA as the genetic material, is the very process that Streptococcus pneumoniae uses during evolution in its real in vivo environment," says Tomasz.

Other phenomena first identified in the laboratory also appear in stages of pneumococcal evolution in vivo. For instance, at least some of the recombination changes observed among the clinical isolates seem to use the "competence" system, a DNA uptake mechanism induced by a specific bacterial quorum sensing agent first detected by Tomasz and colleagues in laboratory experiments. Also, the mechanism of penicillin resistance, first identified by Tomasz and colleagues in the 1980s as changes in the affinity of penicillin target proteins known as penicillin binding proteins, or PBPs, is shown to involve the borrowing of genes from other bacteria, a finding previously documented in studies of individual penicillin resistant isolates.

"Perhaps the most fascinating part of the research is the description of how rapidly this clone has responded to massive in vivo interventions in the clinical environment, such as the introduction of penicillin and other antibiotics and more recently the introduction of conjugate anti-pneumococcal vaccines," says Tomasz. "These vaccines are directed against the most abundant serotypes of this bacterium, which are carried in the nasopharynx of children and which cause invasive disease."

"This research also demonstrates the importance of close collaborations between groups like the Sanger Laboratory, with expertise in high resolution genomic analysis, and laboratories that can provide carefully characterized c
'/>"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
2. Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
3. Researchers identify biomarkers of poor outcomes in preemies
4. Research suggests HIV causes rapid aging in key infection-fighting cells
5. President Obama calls for increased investment in science, including biomedical research
6. Researchers register new species using DNA-based description
7. 23andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee
8. Purdue team creates engineered organ model for breast cancer research
9. Blue crab research may help Chesapeake Bay watermen improve soft shell harvest
10. Research into synthetic antibodies offers hope for new diagnostics
11. ASM Biodefense and Emerging Diseases Research Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... fast and accurate tool to diagnose tuberculosis in ... developed test (TAM-TB assay) is the first reliable ... The test features excellent specificity, a similar sensitivity ... a blood test. The promising findings are a ... children, particularly in tuberculosis-endemic regions. , The study ...
(Date:8/31/2014)... busy attacking us, germs go after each other. But ... for the infected microbes: Sometimes viruses actually carry helpful ... its diet or better attack its own hosts. , ... system would robotically destroy anything it recognized as invading ... now revealed that one variety of the bacterial immune ...
(Date:8/31/2014)... diagnosis has changed very little. After taking a blood sample ... glass slide, stains it with a special dye, and looks ... disease. This approach gives an accurate count of how many ... disease severity but is not ideal because there is ... Singapore-MIT Alliance for Research and Technology (SMART) has now come ...
Breaking Biology News(10 mins):New tuberculosis blood test in children is reliable and highly specific 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3A new way to diagnose malaria 2A new way to diagnose malaria 3
... perennial wheat to be grown on any significant basis in ... Texas Agricultural Experiment Station plant pathologist., From wheat producers ... is finding a groundswell of interest as he begins planting ... wheat study., Rush obtained his initial perennial wheat seed ...
... Barbara, Calif.) -- By peering deep into evolutionary history, ... discovered the origins of photosensitivity in animals. ... the scientific journal PLoS ONE. The scientists studied the ... animals that have existed for hundreds of millions of ...
... convene for two days in Germany, Oct. 18-19, to ... foster better economic and social conditions in Africa through ... pledged in the declarations of the Gleneagles and Heiligendamm ... development. About 70 experts from nine African nations, ...
Cached Biology News:A wheat for all seasons -- and reasons 2A wheat for all seasons -- and reasons 3UCSB researchers discover the dawn of animal vision 2Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin 2Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin 3
(Date:8/29/2014)... Pittcon is pleased to announce that the 2015 ... Scientific, have organized a session on nanotechnology for presentation ... Asia’s largest analytical and scientific instruments show, will be ... , The four speakers in this U.S. symposium, “Thinking ... Single Cells” will present their use of nanotechnology to ...
(Date:8/29/2014)... Due to a misstatement posted by the Family ... Technology Center, LLC ( ASCTC ) was reported as an ... might benefit ALS patients. Because of ASCTC's exclusive focus ... and therapeutic applications, FRC listed ASCTC as one of several ... wish not to support research that requires the death of ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
Breaking Biology Technology:Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3
... Florida in mid-October. Late in the month, Florida Governor Jeb ... negotiations to create and pass a bill creating a $369 ... for the Scripts Research Institute to focus on biotechnology research ... an example of a state that successfully attracted a private ...
... university, an emerging biotech industry, a well educated work force ... has a $3.2 billion budget deficit and a per capita ... below the national average in citizens with a 4-year degree, ... states. The current state of our economy presents a complex ...
... took huge strides last week. In fact, the technology ... mortals might use in everyday communications. , ,What's driving ... executive board rooms to the stuff of ordinary communications? ... the availability of low-cost, high-quality desktop video cameras; and ...
Cached Biology Technology:Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 2Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 3Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 4WARF Collaboration a Win-Win for Wisconsin 2WARF Collaboration a Win-Win for Wisconsin 3Video Conferencing for the Masses 2Video Conferencing for the Masses 3
Mouse monoclonal antibody raised against a partial recombinant STAU2. NCBI Entrez Gene ID = STAU2...
...
Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
... provides optimized blocking and wash solutions ... Ready-to-use wash solutions have been validated ... Slides for Microarrays (Product Code S ... 1L • Microarray Post Hybridization Wash ...
Biology Products: