Navigation Links
New research traces evolutionary path of multidrug-resistant strep bacteria
Date:1/28/2011

e importantly, the findings provide evidence that the mechanism of genetic change in S. pneumoniae is primarily not through acquisition of point mutations but more often 88 percent of the time through genetic recombination.

"The phenomenon of genetic transformation, which led Oswald Avery and his Rockefeller colleagues in 1944 to identify DNA as the genetic material, is the very process that Streptococcus pneumoniae uses during evolution in its real in vivo environment," says Tomasz.

Other phenomena first identified in the laboratory also appear in stages of pneumococcal evolution in vivo. For instance, at least some of the recombination changes observed among the clinical isolates seem to use the "competence" system, a DNA uptake mechanism induced by a specific bacterial quorum sensing agent first detected by Tomasz and colleagues in laboratory experiments. Also, the mechanism of penicillin resistance, first identified by Tomasz and colleagues in the 1980s as changes in the affinity of penicillin target proteins known as penicillin binding proteins, or PBPs, is shown to involve the borrowing of genes from other bacteria, a finding previously documented in studies of individual penicillin resistant isolates.

"Perhaps the most fascinating part of the research is the description of how rapidly this clone has responded to massive in vivo interventions in the clinical environment, such as the introduction of penicillin and other antibiotics and more recently the introduction of conjugate anti-pneumococcal vaccines," says Tomasz. "These vaccines are directed against the most abundant serotypes of this bacterium, which are carried in the nasopharynx of children and which cause invasive disease."

"This research also demonstrates the importance of close collaborations between groups like the Sanger Laboratory, with expertise in high resolution genomic analysis, and laboratories that can provide carefully characterized c
'/>"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
2. Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
3. Researchers identify biomarkers of poor outcomes in preemies
4. Research suggests HIV causes rapid aging in key infection-fighting cells
5. President Obama calls for increased investment in science, including biomedical research
6. Researchers register new species using DNA-based description
7. 23andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee
8. Purdue team creates engineered organ model for breast cancer research
9. Blue crab research may help Chesapeake Bay watermen improve soft shell harvest
10. Research into synthetic antibodies offers hope for new diagnostics
11. ASM Biodefense and Emerging Diseases Research Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... Fla. (November 4, 2014) — Think about the way ... How do neighboring cells know that they are supposed ... how do these tissues find the correct place and ... answering these crucial questions. , In a new study, ... to communicate with their surrounding neighbors, at the head-trunk ...
(Date:11/4/2014)... , November 4, 2014   ... vertical market growth   Fuel3D , a ... closed a funding round totaling $6.4 million (£4 million). This ... funding secured earlier this year and paves the way for ... 2015. The funding round was led by Chimera ...
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
Breaking Biology News(10 mins):The inside story: How the brain and skull stay together 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... and the ECI Biochemical Engineering Conferences have announced ... at the University of Delaware and Director of the ... Biochemical Engineering Journal Young Investigator Award. This ... contributed to the field of biochemical engineering by a ...
... examining chromosomes in human eggs a few hours after ... a healthy baby, a researcher told the 25th annual ... Embryology today (Monday 29 June). Dr. Elpida Fragouli, from ... UK, and Reprogenetics UK, said that her team,s work ...
... Approximately 58 km southeast of Shingu City, Japan--Deepsea Drilling ... Nankai Trough Seismogenic Zone off the Kii Peninsula of ... in water depths of 2,054 meters. Following sea floor ... blow-out prevention (BOP) system into an upper section of ...
Cached Biology News:Kelvin Lee winner of Biochemical Engineering Journal Young Investigator Award 2New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis 2New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis 3First riser-drilling research operations undertaken 2
(Date:11/22/2014)... 2014 The “Chiral Chromatography Columns ... Material (Metal, Glass, Plastic), by Application [GC, LC ... Forecast to 2018” analyses and studies the major ... America, Europe, Asia, and Rest of the World. ... figures spread through 135 pages and in-depth TOC ...
(Date:11/22/2014)...  The element of surprise has been a major ... without warning. Until now, epidemiologists had nothing to measure ... resulting in suboptimal responses to both the H1N1 pandemic ... Photo - http://photos.prnewswire.com/prnh/20141121/160242 That ... virus gene structural changes have been found that invariably ...
(Date:11/21/2014)... November 21, 2014 , ...   Mariano Rodríguez es elegid vicepresidente senior ... KLOX está en marcha para comenzar de forma rápida ... heridas de reciente aprobación en Europa   , ... complace al anunciar los siguientes nombramientos: Todd ...
(Date:11/21/2014)... BELLINGHAM, Washington, USA (PRWEB) November 19, 2014 ... used in our lives was shared with more than ... undergraduate and postgraduate students from the University of Otago ... Outreach Grant . The Otago students, members of the ... Southland New Zealand in early September, giving children from ...
Breaking Biology Technology:Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5Viruses' Advantage of Surprise is Lost 2KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3
... Presented at the Pediatric Academic Societies Annual Meeting ... Statistically-Significant Association between SpCO and Measures of Lung ... /PRNewswire-FirstCall/ -- Masimo (Nasdaq: ... Measure-Through Motion and Low-Perfusion pulse oximetry, announced today ...
... Insmed Inc. (Nasdaq: INSM ), a biopharmaceutical company, today reported results ... , , ... Finalized sale of follow-on biologics (FOB) assets to Merck & Co., ... Net of finance and ...
... Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be presenting ... Tuesday, May 19, 2009 at 11:30 a.m. ET / 8:30 ... chief executive officer of Amylin Pharmaceuticals, will provide a corporate ... a recording will be made available following the event. The ...
Cached Biology Technology:New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 2New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 3New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 4New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children 5Insmed Announces First Quarter 2009 Financial Results 2Insmed Announces First Quarter 2009 Financial Results 3Insmed Announces First Quarter 2009 Financial Results 4Insmed Announces First Quarter 2009 Financial Results 5Insmed Announces First Quarter 2009 Financial Results 6Insmed Announces First Quarter 2009 Financial Results 7Insmed Announces First Quarter 2009 Financial Results 8Insmed Announces First Quarter 2009 Financial Results 9
...
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
Mouse polyclonal antibody raised against a partial recombinant COASY. NCBI Entrez Gene ID = 80347...
... Antibody against Nonmuscle Myosin II Heavy ... (Stored in TBS + 0.03% Thimerosal) ... peptide SDVNETQPPQSE corresponding to the C-terminus ... B (MHC-B) This antibody is effective ...
Biology Products: