Navigation Links
New research helps predict susceptibility to Burkitt lymphoma
Date:12/11/2012

ontrol samples from young children. These young children were either resident in Pf malaria endemic areas of Ghana, had eBL, or were the same age, sex, and of the same village to match a child who did not have eBL. Bethony and his colleagues used an immunomics approach to their antibody response to Pf malaria. This enabled different statistical and epidemiological associations to be made between a range of antibody response to Pf malaria antigens and eBL, establishing a pattern of immune responses rather than a single immune response, identifying the children who are at risk for developing eBL.

"Plasmodium falciparum malaria has long been suspected as an important trigger to Epstein Barr Virus associated lymphoma of very young children living in Equatorial Africa," said Bethony. "Our study adds to this literature, explaining that it is not simply the presence or absence of Pf malaria infection, but the breath and complexity of the antibody response to malaria that may be the true indicating factor for who develops eBL and who does not."

The study showed a significant increase in the risk of developing eBL in young children who had a distinct pattern of antibody responses to several different recombinant Pf malaria antigens, including some antigens which are vaccine candidates. Of special note, the study also found a significant decreased risk of eBL in children with antibodies to SE36, a vaccine candidate protein that has been associated with lower risk of malaria in epidemiological studies.

These results not only confirm a strong association between Pf malaria and eBL, but provide a new perspective on the long established relationship between Pf malaria and eBL. This could pave the way for future studies that use protein arrays, containing hundreds of recombinant proteins to develop an antibody signature for children most at risk of developing eBL during Pf malaria infection.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coral researcher recognized with prestigious award
2. Researchers identify new components of the epigenetic code for honey bee development
3. Fred Hutchinson Cancer Research Center partners with GlaxoSmithKline to develop muscular dystrophy therapeutics
4. UCI radiology researcher to aid NASA bone density study
5. Researcher finds gender differences in seasonal auditory changes
6. From fish to man: Research reveals how fins became legs
7. Stem cell research provides hope for infertile cancer survivors
8. German Research Foundation to fund globally unique twin study on social inequality
9. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
10. Researchers find new genetic pathway behind neurodevelopmental disorders
11. Researchers investigate impacts of climate change on rare tropical plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
(Date:10/15/2014)... The book ,Models of Life, is a non-traditional biophysics ... itself. The book is a journey of discovery into ... of life and biological regulation. It is about how ... strategic communication between the billions of cells in an ... the relationships between principles, which can be found on ...
(Date:10/15/2014)... have linked increased resistance to bacterial pneumonia in female ... hormone estrogen. , Females are naturally more resistant to ... scientists has shown that increased resistance to bacterial pneumonia ... oxide synthase 3 (NOS3). They also show that this ... female sex hormone estrogen. , The team, lead by ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3New book about life as seen from physics 2
... Canadell, from the Global Carbon Project and CSIRO Marine and ... deforestation releases 1.5 billion tonnes of carbon each year into ... nearly 20 per cent of carbon emissions due to human ... to 130 billion tonnes of carbon by 2100, which is ...
... you’re grazing normally on algae in the rocky intertidal zone ... infected by a parasite. But the better news is, according ... you might have more to eat if plenty of your ... Proceedings of the National Academy of Sciences Early Edition ( ...
... rapid genetic adaptations in the nematode Acrobeloides nanus. ... lay more eggs under polluted conditions than the ... demonstrated this in her study into the long-term ... , Environmental pollution is an important cause of ...
Cached Biology News:Confirmed -- deforestation plays critical climate change role 2Parasites' impact goes beyond host to affect ecosystem 2Parasites' impact goes beyond host to affect ecosystem 3Asexual worm quickly adapts to soil contamination 2
(Date:10/20/2014)... ON , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... $1.7 million which brings Q3 orders to $5.8 million and provides ... control projects in North America and one ... continue to bid new projects at record levels," said Peter ... were higher at the end of Q3 than they have been ...
(Date:10/20/2014)... -- PureTech , a science and technology ... announced today the closing of a $55 million ... Perpetual, a $120 Billion group of funds. The ... pipeline forward and to advance new healthcare related ... to really go for the big ideas that ...
(Date:10/20/2014)... 20, 2014 Local veterinary surgeon, Dr. ... investigational study of donor stem cells for dogs with ... therapy and has performed clinical stem cell therapy for ... to determine if a single injection of donor stem ... help reduce pain and inflammation in the treated joints. ...
(Date:10/19/2014)... 2014 NextCODE Health, which enables clinicians and researchers ... time, today announced the launch of its new genomic data ... the American Society of Human Genetics (ASHG) annual meeting in ... up and apply for free beta access, visit www.nextcode.com ... can be viewed here . The Exchange: ...
Breaking Biology Technology:PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... up nearly 23% of fund raising goal for Central ... Company,(NYSE: LLY ) President and Chief Executive Officer ... United Way of Central Indiana for,its and other United ... of Lilly employees and retirees across the,United States with ...
... 13 Palatin Technologies,Inc. (Amex: PTN ) will ... Monday, November 17, 2008 before the open of the ... conference call and live audio webcast,hosted by Palatin,s executive ... discuss the results of operations in greater detail and ...
... 13 , - Announce Winners of ... Elsevier, the world,s leading research publisher of ... Institutions announced,today winners of the first annual ... to recognize outstanding young scientists and researchers,in ...
Cached Biology Technology:Lilly Contributes $11.1 Million to United Way Annual Campaign 2Palatin Technologies to Report Fiscal Year 2009 First Quarter Results; Conference Call and Webcast on November 17, 2008 2Elsevier and the Association of Southeast Asian Institutions 2Elsevier and the Association of Southeast Asian Institutions 3Elsevier and the Association of Southeast Asian Institutions 4