Navigation Links
New research helps predict susceptibility to Burkitt lymphoma
Date:12/11/2012

ontrol samples from young children. These young children were either resident in Pf malaria endemic areas of Ghana, had eBL, or were the same age, sex, and of the same village to match a child who did not have eBL. Bethony and his colleagues used an immunomics approach to their antibody response to Pf malaria. This enabled different statistical and epidemiological associations to be made between a range of antibody response to Pf malaria antigens and eBL, establishing a pattern of immune responses rather than a single immune response, identifying the children who are at risk for developing eBL.

"Plasmodium falciparum malaria has long been suspected as an important trigger to Epstein Barr Virus associated lymphoma of very young children living in Equatorial Africa," said Bethony. "Our study adds to this literature, explaining that it is not simply the presence or absence of Pf malaria infection, but the breath and complexity of the antibody response to malaria that may be the true indicating factor for who develops eBL and who does not."

The study showed a significant increase in the risk of developing eBL in young children who had a distinct pattern of antibody responses to several different recombinant Pf malaria antigens, including some antigens which are vaccine candidates. Of special note, the study also found a significant decreased risk of eBL in children with antibodies to SE36, a vaccine candidate protein that has been associated with lower risk of malaria in epidemiological studies.

These results not only confirm a strong association between Pf malaria and eBL, but provide a new perspective on the long established relationship between Pf malaria and eBL. This could pave the way for future studies that use protein arrays, containing hundreds of recombinant proteins to develop an antibody signature for children most at risk of developing eBL during Pf malaria infection.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Coral researcher recognized with prestigious award
2. Researchers identify new components of the epigenetic code for honey bee development
3. Fred Hutchinson Cancer Research Center partners with GlaxoSmithKline to develop muscular dystrophy therapeutics
4. UCI radiology researcher to aid NASA bone density study
5. Researcher finds gender differences in seasonal auditory changes
6. From fish to man: Research reveals how fins became legs
7. Stem cell research provides hope for infertile cancer survivors
8. German Research Foundation to fund globally unique twin study on social inequality
9. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
10. Researchers find new genetic pathway behind neurodevelopmental disorders
11. Researchers investigate impacts of climate change on rare tropical plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... when microbial pathogens are growing increasingly resistant to the ... of Wisconsin scientists has synthesized a potent new class ... staph infections. , Writing online in the Journal ... by University of Wisconsin-Madison chemistry Professor Helen Blackwell describes ... of Staphylococcus aureus , a bacterium at the ...
(Date:5/22/2013)... technique that can detect molecular variants in chemical mixtures ... the most important, though time-consuming, processes in analytical chemistry. ... Nature , post-doctoral researcher David Patterson, Professor of Physics ... for Free-Electron Laser Science (CFEL) in Hamburg, Germany developed ... identify molecular variants apart, and to determine how much ...
(Date:5/22/2013)... human health effects from disposal of millions of ... to recommend stronger government policies to encourage recovery, ... That,s the conclusion of a new paper in ... . , Oladele A. Ogunseitan and colleagues point ... powering everything from smart phones to components in ...
Breaking Biology News(10 mins):University of Wisconsin chemists find new compounds to curb staph infection 2Detecting mirror molecules 2Detecting mirror molecules 3
... protein regulates secretion levels in the fruit fly's salivary ... the May 15 issue of Development, the finding improves ... is a critical ability of certain glands and cell ... researchers discovered that a protein called CrebA single-handedly controls ...
... University of Illinois at Chicago have identified an ... both humans and the much-studied laboratory nematode C. ... on muscle function. , The neurotransmitter acetylcholine binds ... neuromuscular junctions, causing them to contract. Previously, researchers ...
... made is crucial to the normal functioning of living ... into RNA molecules and then translated into the amino ... code for proteins--some make RNA molecules called microRNAs. These ... proteins. A new paper in PLoS Computational Biology shows ...
Cached Biology News:Study: Well-known protein helps stem cells become secretory cells 2Small worm yields big clue on muscle receptor action 2MicroRNAs play a big part in gene regulation - and evolution 2
(Date:5/24/2013)... Madison, WI (PRWEB) May 24, 2013 ... to the discovery and development of calcium-binding proteins ... publication of safety assessment study of apoaequorin ... an international journal published for the British Industrial ... the study was to investigate potential adverse effects, ...
(Date:5/23/2013)... 23, 2013 Venaxis, Inc. (Nasdaq:   APPY), ... obtaining FDA clearance and commercializing its rapid, protein biomarker-based ... of an underwritten public offering of 10,000,000 shares of ... shares of its common stock at an exercise price ... price of $1.25 per share and related warrant.  Venaxis ...
(Date:5/23/2013)... Graphite Metallizing Corporation announces a ... in stainless steel pillow blocks. This series combines ... the application and installation versatility of pillow blocks. ... work exceptionally well when submerged in water, water-soluble ... as acids, alkalies, hydrocarbons, black liquor, and liquid ...
(Date:5/23/2013)... BROWNSBURG, Ind. , May 23, 2013  Rahal ... leader in human cord blood stem cell banking and ... sponsor of the No. 16 Acorn Stairlifts Indy car ... is for the remainder of the IZOD IndyCar 2013 ... Racing (RLL) will work to support awareness of umbilical ...
Breaking Biology Technology:Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 3Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3
... Stereotaxis, Inc. (Nasdaq:, STXS ) announced today ... quarter and full year ended December 31, 2008, on ... will host a conference call and,webcast on Thursday, February ... Company,s fourth quarter results and current corporate developments. The,dial-in ...
... Pharmaceuticals, Inc., a privately held drug development company, ... New Drug (IND) application with the U.S. Food ... anticancer compound. GGTI-2418 is a synthetic peptidomimetic ... to induce apoptosis by downregulating several pivotal oncogenic ...
... Ltd. (Nasdaq: XTLB , TASE: XTL) today ... a letter from a shareholder who,owns more than 5% ... an extraordinary shareholders, meeting (EGM) of the Company as,soon ... , 1. that Boaz Shweiger ...
Cached Biology Technology:Stereotaxis Announces Fourth Quarter and Full Year 2008 Earnings Release Date and Conference Call 2Tigris Pharmaceuticals Files IND Application for GGTI-2418 2Tigris Pharmaceuticals Files IND Application for GGTI-2418 3Corrected: XTL Biopharmaceuticals to Convene Extraordinary Shareholders' Meetings after Receipt of Shareholder Letter 2
Request Info...
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
supplied with 10x reaction buffer...
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
Biology Products: