Navigation Links
New paper sheds light on bacterial cell wall recycling
Date:9/8/2008

A new paper by a team of researchers led by Shahriar Mobashery, Navari Family Professor of Life Sciences at the University of Notre Dame, provides important new insights into the process by which bacteria recycle their cell wall.

The cell wall is a critically important entity for bacteria and essential for their survival. It is a rigid entity encasing the bacterium, and antibiotics are designed to interfere with disease processes by affecting its maturation. The function of antibiotics is to impair the cell wall, leading to bacterial death.

Scientists have determined that during bacterial growth a substantial amount of the parental cell wall is recycled. Although the recycling process has been known, its intricacies have not been well understood to date.

Mobashery's team synthesized pieces of the cell wall of the bacterium Escherichia coli in his laboratory and was able to use the synthetic wall components to observe the chemical reactions that take place during the recycling process.

The researchers found that a member of the lytic transglycosylases family of enzymes known as M1tB performed the requisite cell wall fragmentation on the synthetic sample of the cell wall from their laboratory. They also were able to measure the rate of the transformation by M1tB, determining that 14,000 pieces of the cell wall are processed by each molecule of M1tB in one bacterial generation.

The product of the M1tB reaction on the cell wall is the entity that initiates the recycling event, but when it diffuses out of the bacterium, it causes the onset of the pro-inflammatory events associated with bacterial infections.


'/>"/>

Contact: Shahriar Mobashery
mobashery@nd.edu
574-631-2933
University of Notre Dame
Source:Eurekalert

Page: 1

Related biology news :

1. Beyond batteries: Storing power in a sheet of paper
2. Coal and black liquor can produce energy from papermaking
3. New paper examines dams effects on California salmon
4. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
5. RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos
6. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
7. New whitepaper offers options for university implementation of NIH policy
8. For the paper trail of life on Mars or other planets, find cellulose
9. Nature paper describes technique for extracting hierarchical structure of networks
10. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
11. U.S. IEEE members to report on Sci-Tech at California newspapers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... research, supported by the National Science Foundation (NSF), ... uniformly accelerates atmospheric warming, indicating instead that certain ... emit into the atmosphere. , The study, ... , focuses on thermokarst lakes, which occur as ... with melted fresh water, converting what was previously ...
(Date:7/31/2014)... long-term follow-up study (HPV-023; NCT00518336) shows the ... human papilloma virus (HPV) vaccine Cervarix. Women ... followed for more than nine years, and ... 100%. This is the longest follow-up report ... https://www.landesbioscience.com/journals/vaccines/article/29532/ for the full paper. , ...
(Date:7/31/2014)... of animal models against the highly infectious and virulent ... disease that kills approximately 30,000 Americans annually. The research ... Immunity . , In the study, the vaccine ... toxins produced by C. difficile , as well ... that mimics the human disease, after only two immunizations. ...
Breaking Biology News(10 mins):Certain Arctic lakes store more greenhouse gases than they release 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3C. difficile vaccine proves safe, 100 percent effective in animal models 2
... CHURCH, Va., Feb. 2 CSC (NYSE: ... 12 contractors awarded a Biometrics Operations and Support Services ... Biometrics Task Force (BTF). The indefinite-delivery/indefinite-quantity (IDIQ) contract covers ... to meet the mission needs of BTF business and ...
... 25 percent of eligible African-American adolescents have received the ... Association for Cancer Research conference on the Science of ... of the treatment and might respond to more education. ... funding research to develop ways to increase the rate ...
... University is tracking the movement of the Redbay Ambrosia beetle, ... may severely affect the production of avocados, a $15 million ... in the United States near Savannah, Ga., in 2002, the ... causing widespread mortality in Redbay trees. Dr. Frank Koch, a ...
Cached Biology News:CSC Awarded Department of Defense Biometrics Contract 2African-Americans aware and accepting, but often do not receive, the HPV vaccine 2Holy guacamole: invasive beetle threatens Florida's avocados 2
(Date:8/1/2014)... This is a professional and in-depth study on ... Global and China. The report provides a basic overview ... structure. Global market analysis and Chinese domestic market analysis ... and competitive landscape of the market. A comparison between ... The report also focuses on development policies and plans ...
(Date:8/1/2014)... 1. 2014 As one of the 10 ... Annual Meeting & Clinical Lab Expo is the place ... are introduced to the healthcare world. This year, many ... exhibitors will include the latest diagnostic technology in the ... smartphones and biosensors have enabled the development of "labs-on-a-chip" ...
(Date:8/1/2014)... , Aug. 1, 2014 The  PROPEL Center ... number and success rate of early-stage life sciences companies ... it has awarded 15 grants to help ... The MedTech Conference   in Chicago ... conference in North America , bringing ...
(Date:8/1/2014)... 01, 2014 Once a decision has ... This webinar will discuss how to define your tolerance ... speakers Bob Allen, Senior Director of Facilities Integration at ... at Fluor Industrial Services, and special guest Carrier Li, ... at Amgen, as they provide an examination of the ...
Breaking Biology Technology:Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 3Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 4Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2
... 28 /PRNewswire-FirstCall/,-- Evotec AG (Frankfurt Stock Exchange: EVT) ... year ended December 31, 2007., Financial results ... in the,Company,s clinical pipeline and four major corporate ... Technologies (ET), the sale of,the Chemical Development Business ...
... CHAMPAIGN, Ill. Finding a simple and convenient ... identification has been an elusive goal. With current ... ratio too poor, sample preparation too complex or ... service., Now, researchers at the University of Illinois ...
... March 27 Local biotechnology leader,MedImmune announced ... Yiwei Li,has received the distinguished "MedImmune Advancing ... project. The company sponsored the,Montgomery County science ... and presented the award to recognize the ...
Cached Biology Technology:Evotec Announces Financial Results for 2007 2Evotec Announces Financial Results for 2007 3Evotec Announces Financial Results for 2007 4Evotec Announces Financial Results for 2007 5Evotec Announces Financial Results for 2007 6Evotec Announces Financial Results for 2007 7Evotec Announces Financial Results for 2007 8Femtogram-level chemical measurements now possible, U. of I. team reports 2Seneca Valley High School Student Receives Science Award From MedImmune 2Seneca Valley High School Student Receives Science Award From MedImmune 3
...
...
... are designed to rapidly and reliably amplify ... APA Technology. APAgene provides hassle-free, ready-to use ... necessary ingredients are provided in each kit. ... for gap filling, localized cloning of genomic ...
N,N'-Methylene-bis-acrylamide, Ultra Pure...
Biology Products: