Navigation Links
New paper sheds light on bacterial cell wall recycling
Date:9/8/2008

A new paper by a team of researchers led by Shahriar Mobashery, Navari Family Professor of Life Sciences at the University of Notre Dame, provides important new insights into the process by which bacteria recycle their cell wall.

The cell wall is a critically important entity for bacteria and essential for their survival. It is a rigid entity encasing the bacterium, and antibiotics are designed to interfere with disease processes by affecting its maturation. The function of antibiotics is to impair the cell wall, leading to bacterial death.

Scientists have determined that during bacterial growth a substantial amount of the parental cell wall is recycled. Although the recycling process has been known, its intricacies have not been well understood to date.

Mobashery's team synthesized pieces of the cell wall of the bacterium Escherichia coli in his laboratory and was able to use the synthetic wall components to observe the chemical reactions that take place during the recycling process.

The researchers found that a member of the lytic transglycosylases family of enzymes known as M1tB performed the requisite cell wall fragmentation on the synthetic sample of the cell wall from their laboratory. They also were able to measure the rate of the transformation by M1tB, determining that 14,000 pieces of the cell wall are processed by each molecule of M1tB in one bacterial generation.

The product of the M1tB reaction on the cell wall is the entity that initiates the recycling event, but when it diffuses out of the bacterium, it causes the onset of the pro-inflammatory events associated with bacterial infections.


'/>"/>

Contact: Shahriar Mobashery
mobashery@nd.edu
574-631-2933
University of Notre Dame
Source:Eurekalert

Page: 1

Related biology news :

1. Beyond batteries: Storing power in a sheet of paper
2. Coal and black liquor can produce energy from papermaking
3. New paper examines dams effects on California salmon
4. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
5. RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos
6. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
7. New whitepaper offers options for university implementation of NIH policy
8. For the paper trail of life on Mars or other planets, find cellulose
9. Nature paper describes technique for extracting hierarchical structure of networks
10. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
11. U.S. IEEE members to report on Sci-Tech at California newspapers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... people take stress in stride; others are done in ... the molecular mechanisms of this so-called stress gap in ... that could lead researchers to better understand the development ... "Like people, each animal has unique experiences as it ... life experiences can alter the expression of genes, and ...
(Date:9/1/2014)... making us fat? An increasing amount of research shows ... and a more sedentary lifestyle. Now, a new Cornell ... alike. Some TV programs might lead people to eat ... if you,re watching an action movie while snacking your ... Ph.D. lead author on the new article just published ...
(Date:9/1/2014)... MA ─ Dietary quality in the U.S. has improved ... trans fat intakebut overall dietary quality remains poor and ... according to a new study from Harvard School of ... direct evidence to date that the extensive efforts by ... are having some payoff, but it also indicates that ...
Breaking Biology News(10 mins):Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3Can action movies make you fat? 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... , , , , ... , AUDIO: Learn ... , Click here for more information. ... , , , , , ...
... have begun to categorize breast cancers into four main ... cells. Which category a cancer falls into generally determines ... cancers in one of the four groups called ... particularly tricky to treat because they usually don,t respond ...
... host the U.S. book release of Women Scientists in ... of Academies of Science (IANAS). This compilation of ... to inspire students, especially young women, to pursue science ... Spanish, the book includes the stories of eminent female ...
Cached Biology News:Bad decisions arise from faulty information, not faulty brain circuits 2Bad decisions arise from faulty information, not faulty brain circuits 3Bad decisions arise from faulty information, not faulty brain circuits 4UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment 2UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment 3
(Date:9/2/2014)... CAMBRIDGE, Massachusetts , September 2, 2014 ... experience to BioData,s research and lab management services  ... lab management service, is pleased to announce the appointment ... CEO. Culot most recently served as VP Marketing and ... for life science research and clinical applications. ...
(Date:9/2/2014)... The inventors of tinAway, a novel ... are seeking support for development costs through a crowdfunding ... http://igg.me/at/tinaway ), was launched on September 1, 2014. , ... and is based on ten years of neuroscience ... and software engineers, Dr. Ian Dixon and Mr. Tony ...
(Date:9/1/2014)... , Sept. 1, 2014 Reportlinker.com announces ... in its catalogue: India Solid Waste ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In ... the main governing bodies responsible for complete handling ... On an average, around 135,000 MT solid waste ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... $1,712.1 million by 2019 from $1,070.7 million in ... 2014 to 2019. The global oligonucleotide synthesis market ... services, applications, end users, and geography. The synthesized ... growth rate in the oligonucleotide synthesis market during ...
Breaking Biology Technology:Louis Culot Appointed as BioData's CEO 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 89.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 29.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 49.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5
... 7 Nektar,Therapeutics (Nasdaq: NKTR ) President and ... upcoming Natixis Bleichroeder Second Annual Hidden Gems,Conference in New ... at 2:30 p.m. ET., The presentation will be ... Relations, Events Calendar section of the Nektar website:, http://www.nektar.com ...
... Customer the Broad Institute of MIT and Harvard, Among ... ... 7 Isilon(R) Systems (Nasdaq:,ISLN), the leader in clustered storage, ... the growing data storage,challenges facing life science research organizations as ...
... Oct. 6 NEXCORE Technology, Inc., a,world-class original ... agreement with GI Supply of Camp Hill, Pa, ... Polar Wand is a portable,device that uses endoscopic ... gastrointestinal tract in patients resistant to conventional,endoscopic therapy., ...
Cached Biology Technology:Isilon CTO Addresses Life Science Data Storage Challenges at Harvard Medical School's BioMedical HPC Leadership Summit 2Isilon CTO Addresses Life Science Data Storage Challenges at Harvard Medical School's BioMedical HPC Leadership Summit 3NEXCORE Technology Selected to Manufacture New Endoscopic Cryotherapy Device 2
... PCR Enhancer (with betaine) substantially improves ... and specificity for amplification of many ... in PCR eliminates the base-pair composition ... thermal stability, suppresses pauses of DNA ...
... Biotin Streptavidin-AP Systems provide rapid, precise ... antigens in frozen or paraffin-embedded tissue, ... systems also facilitate double or triple ... performed simultaneously with primary antibodies of ...
... computer controlled pre-amplifier suitable for a broad ... input for recording physiological signal such as ... transducer input for use with a wide ... options include a stimulus artefact clamp to ...
... Two sizes available for use with 96- or ... Thermo-Mat™ 96 for ease of location on 96-tube plates ... in the skirt of the plate* Efficient sealing ... used in conjunction with screw or clip-down hot lid ...
Biology Products: