Navigation Links
New paper sheds light on bacterial cell wall recycling
Date:9/8/2008

A new paper by a team of researchers led by Shahriar Mobashery, Navari Family Professor of Life Sciences at the University of Notre Dame, provides important new insights into the process by which bacteria recycle their cell wall.

The cell wall is a critically important entity for bacteria and essential for their survival. It is a rigid entity encasing the bacterium, and antibiotics are designed to interfere with disease processes by affecting its maturation. The function of antibiotics is to impair the cell wall, leading to bacterial death.

Scientists have determined that during bacterial growth a substantial amount of the parental cell wall is recycled. Although the recycling process has been known, its intricacies have not been well understood to date.

Mobashery's team synthesized pieces of the cell wall of the bacterium Escherichia coli in his laboratory and was able to use the synthetic wall components to observe the chemical reactions that take place during the recycling process.

The researchers found that a member of the lytic transglycosylases family of enzymes known as M1tB performed the requisite cell wall fragmentation on the synthetic sample of the cell wall from their laboratory. They also were able to measure the rate of the transformation by M1tB, determining that 14,000 pieces of the cell wall are processed by each molecule of M1tB in one bacterial generation.

The product of the M1tB reaction on the cell wall is the entity that initiates the recycling event, but when it diffuses out of the bacterium, it causes the onset of the pro-inflammatory events associated with bacterial infections.


'/>"/>

Contact: Shahriar Mobashery
mobashery@nd.edu
574-631-2933
University of Notre Dame
Source:Eurekalert

Page: 1

Related biology news :

1. Beyond batteries: Storing power in a sheet of paper
2. Coal and black liquor can produce energy from papermaking
3. New paper examines dams effects on California salmon
4. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
5. RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos
6. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
7. New whitepaper offers options for university implementation of NIH policy
8. For the paper trail of life on Mars or other planets, find cellulose
9. Nature paper describes technique for extracting hierarchical structure of networks
10. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
11. U.S. IEEE members to report on Sci-Tech at California newspapers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
Breaking Biology Technology: