Navigation Links
New mouse viruses could aid hepatitis research
Date:4/8/2013

Newly discovered mouse viruses could pave the way for future progress in hepatitis research, enabling scientists to study human disease and vaccines in the ultimate lab animal. In a study to be published in mBio, the online open-access journal of the American Society for Microbiology, scientists describe their search for viruses related to the human hepatitis C virus (HCV) and human pegiviruses (HPgV) in frozen stocks of wild mice. The discovery of several new species of hepaciviruses and pegiviruses that are closely related to human viruses suggests they might be used to study these diseases and potential vaccines in mice, without the need for human volunteers.

About 2% of the population is infected with the hepatitis C virus and 5% is infected with human pegiviruses, but it's been difficult to study new drugs or develop vaccines against these infections because the human strains do not infect animals that can be studied in the lab. Lead author Amit Kapoor of Columbia University says it surprised him to find similar viruses in mice.

"People have been waiting for decades to find something like this. It was shocking for me to see that the viruses are there and there are so many of them," says Kapoor.

Kapoor and his colleagues screened an archive of more than 400 frozen rodents, mostly deer mice, for viruses related to the human hepatitis C virus and human pegiviruses. The search turned up a number of candidates, and they selected two for complete genome sequencing: a rodent hepacivirus (RHV) found in deer mice and a rodent pegivirus (RPgV) found in a white-throated woodrat. Sequencing confirmed that the viruses are very closely related to human strains but they represent several novel species in the Hepacivirus and Pegivirus genera within the family Flaviviridae.

These rodent viruses have genes, proteins, and translational elements that closely mirror those found in human hepaciviruses and pegiviruses, suggesting th
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
2. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
3. Researchers generate a mutant mouse model useful in the treatment of neuromuscular diseases
4. Transplanted neural stem cells slows als onset and progression in mouse models
5. Early menopause: A genetic mouse model of human primary ovarian insufficiency
6. NPointer from Neurotechnology Uses Hand Gestures to Control and Navigate Computer Programs Without a Mouse or Touchpad
7. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
8. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
9. Pesticide application as potential source of noroviruses in fresh food supply chains
10. Viruses: More survival tricks than previously thought
11. New device better traps viruses, airborne pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced ... Overview" report to their offering. , ... an individual is who she/he is claiming to be, and ... person,s unique physical characteristics, such as fingerprint, hand or palm ...
(Date:1/22/2015)... Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of ... of its new website design. "When we launched ... says Peter O,Neill , founder and CEO of FindBiometrics. ... needs involvement from the key players on a very broad ...
(Date:1/22/2015)... Hall E -   EyeLock Inc. , a market leader ... its EyeLock ID technology integrated in a 3D printed automobile ... Ridge National Laboratory (ORNL) at the 2015 North ... is being used to validate the driver and authorize the ...
Breaking Biology News(10 mins):Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3
... In the first field trial of plants genetically tweaked ... plants handily beat out their wild-type counterparts. The results ... alternative for cleaning up polluted soil. , The new ... Science and Technology, show that three transgenic lines of ...
... Hotspots Revisited identifies 34 regions worldwide where 75 percent ... survive within habitat covering just 2.3 percent of the ... the five largest U.S. states). This habitat originally covered ... in size to Russia and Australia combined. The new ...
... novel bio-bar-code amplification (BCA) technology, researchers analyzing fluid from ... protein linked in recent studies to Alzheimer's disease. , ... : , - Gold nanoparticles and bio-bar codes ... Codes for the Ultrasensitive Detection of Proteins ,- ...
Cached Biology News:Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 2Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 3Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 4Biodiversity hotspots identify conservation priorities 2Biodiversity hotspots identify conservation priorities 3Biodiversity hotspots identify conservation priorities 4Biodiversity hotspots identify conservation priorities 5Nanoscale Diagnostic Sets Sights on Alzheimer's 2Nanoscale Diagnostic Sets Sights on Alzheimer's 3
(Date:3/4/2015)... -- Brooklyn residents now have a new place to go ... Nunzio Saulle , M.D., a board-certified physiatrist, is ... Physical Medicine and Rehabilitation (PM&R) practice in ... Health Plus Management, LLC is managing the day-to-day operations ... Avenue. This new PM&R practice will treat patients suffering ...
(Date:3/4/2015)... , Mar. 04, 2015 Research and Markets ... addition of Jain PharmaBiotech,s new report "Biomarkers ... offering. This report follows the ... that can be objectively measured and evaluated as ... as well as pharmacological responses to a therapeutic ...
(Date:3/4/2015)... 2015 /CNW/ - Resverlogix Corp. (TSX:RVX) (the "Company") ... collaborative research program with Emerald Logic, a ... Evolution Technology (FACET), Emerald Logic analyzed Resverlogix,s ... from each of 798 patients who participated ... ASSERT, SUSTAIN and ASSURE. The objective of ...
(Date:3/4/2015)... Proove Biosciences , a ... excited to announce the launch of their CME-accredited ... Management of Pain”. , The continuing medical education ... next year. The focus of the program is ... pain treatments, integrate appropriate pain management techniques, and ...
Breaking Biology Technology:NJS Physical Medicine & Rehabilitation Opening on Flatbush Avenue, Brooklyn, NY 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3
... BERKELEY, Calif., March 28 Aerovance Inc. today,announced ... financing. Oxford,Finance Corporation led the syndicate, which includes ... $10 million from the financing line,at closing. The ... of,corporate milestones., "This financing reflects continued interest ...
... Joins Investor Syndicate, VIENNA, Austria, March ... novel antibodies and antibody fragments,based on its ... it,has acquired future royalty obligations to New ... Modular Antibody Technology was originally developed by ...
... HAMBURG, Germany and OXFORD, England, March 28 /PRNewswire-FirstCall/,-- ... financial,results according to IFRS for the year ended ... year were driven by strong progress in the,Company,s ... of Neuro3d, the sale of Evotec Technologies (ET), ...
Cached Biology Technology:Antibody Engineering Company F-Star Buys Back Royalty Obligations 2Evotec Announces Financial Results for 2007 2Evotec Announces Financial Results for 2007 3Evotec Announces Financial Results for 2007 4Evotec Announces Financial Results for 2007 5Evotec Announces Financial Results for 2007 6Evotec Announces Financial Results for 2007 7Evotec Announces Financial Results for 2007 8
... is a high-quality four-place microplate shaker with ... speed is adjustable from 100 to 1350 ... a small orbit ensure effective shaking for ... quick and easy to set for 0 ...
... Ascent FL is equipped ... luminometric measurement technologies that ... of advanced features of ... Ascent. Fluoroskan Ascent FL ...
Rabbit polyclonal to STUB1 ( Abpromise for all tested applications). entrezGeneID: 10273 SwissProtID: Q9UNE7...
... stainless steel rack holders ... mechanism that permits selection ... angles, and "snap-in" product ... rack holder will accomodate ...
Biology Products: