Navigation Links
New methods to visualize bacterial cell-to-cell communication
Date:7/18/2013

Most bacteria are able to communicate with each other by secreting signaling molecules. Once the concentration of signals has reached a critical density (the Quorum), the bacteria are able to coordinate their behavior. Only when this critical population density has been reached certain genes are activated that lead to, for example, the formation of biofilms or the expression of virulence factors. Bacteria utilize this so-called Quorum Sensing (QS) to synchronize their behavior to regulate functions that benefit the entire population.

The most commonly used signaling molecules are N-Acyl-L-homoserine lactones (AHLs) that are secreted by the bacteria into their surroundings, where they can easily be incorporated by other cells. The AHLs then start binding to specific QS-receptors once a certain density has been reached inside the cell.

Fluorescent labeling of signaling compound to visualize receptors

The research groups under the leadership of Prof. Karl Gademann (University of Basel) and Prof. Leo Eberl (University of Zurich) have succeeded in visualizing live cell-to-cell communication pathways. The scientists added fluorescents tags to natural AHL signaling molecules and were able to show through tests with bacterial cultures that the modified signaling molecule selectively binds to the Burkholderia cenocepacia QS receptor.

B. cenocepacia is a member of a bacterial group known to form biofilms in the lungs of immunocompromised persons or patients suffering from cystic fibrosis, causing severe complications such as pneumonia.

The scientists were also able to detect the receptor in a native population of B. cenocepacia. Here, the natural AHL signaling molecule is competing with its artificial analogue for the binding to the receptor. The fluorescent-labeling agent was equally distributed over the live cell, which made it possible to localize the receptor inside the cytoplasm for the first t
'/>"/>

Contact: Reto Caluori
reto.caluori@unibas.ch
41-612-672-495
University of Basel
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research examines new methods for managing digestive health
2. Researchers question evaluation methods for protected areas in the Amazon
3. Better estrogen-testing methods needed to improve patient care
4. Elsevier announces the launch of a new journal: Methods in Oceanography
5. Nature Methods study: Using light to control cell clustering
6. Modern growing methods may be culprit of coffee rust fungal outbreak
7. Essential informatics methods and tools for analyzing the explosion of NGS data
8. New methods for quantifying antisense drug delivery to target cells and tissues
9. ARS scientists test improved stink bug trapping methods
10. Scientists from Bangalore and Mainz develop new methods for cooling of ions
11. Chilling methods could change meat tenderness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... the 44th Rosenstiel Award for Distinguished Work in Biomedical ... the mechanisms of genomic instability and its implications for ... second alumnus to win the Rosenstiel Award; the first, ... Alt is the Charles A. Janeway Professor of Pediatrics ... an investigator at the Howard Hughes Medical Institute at ...
(Date:10/14/2014)... the house fly genome for the first time, revealing ... insect that thrives in pathogen-rich dung piles and garbage ... journal Genome Biology , will increase understanding of ... quickly adapt to resist insecticides, which could lead to ... carry and transmit more than 100 human and animal ...
(Date:10/14/2014)... A team of scientists led by researchers at ... the University of Miami Miller School of Medicine ... genetic pathway underlying bipolar (manic depressive) disorder, a ... treating bipolar affective disorder, as well as depression ... findings, published online this week in Nature ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
... , is one of the most thoroughly studied organisms ... model for understanding variation in physiology, behavior, life history ... wild. On biological levels from molecular and genetic ... population level, it has proven far more complex than ...
... DNA, the molecule that acts as ... life, is highly resistant against alteration by ultraviolet light, ... puzzling problems. A key aspect is the interaction between ... molecule. Researchers at Kiel University have succeeded in showing ...
... Oct. 9 Aware, Inc. (Nasdaq:,AWRE), a leading supplier ... call to discuss the company,s operating results,for the third ... 5:00 p.m.,Eastern Time. CEO Michael Tzannes and CFO Rick ... is being webcast by Thomson and can be accessed ...
Cached Biology News:Fitness in a changing world 2Fitness in a changing world 3Can genetic information be controlled by light? 2Aware Announces Q3 2008 Earnings Conference Call 2
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar and ... and Forecast (2011 - 2016)," analyzes the chocolate ... the major market drivers, restraints, and opportunities for the ... The global chocolate market is expected to grow from ... an estimated CAGR of 2.7% from 2011 to 2016. ...
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by ... Type & by Geography - Forecasts & Analysis ... vehicle market into various sub segments with an ... report also identifies the factors driving this market, ... the adoption trends. , The unmanned ground vehicle ...
(Date:10/18/2014)... The “Human Insulin Market- by ... Premixed), Modern Human Insulin (Rapid Acting, Long Acting, ... Tresiba, Others) - Forecast to 2018” provides a ... opportunities, current market trends, and strategies impacting the ... and forecasts of the revenue and share analysis. ...
(Date:10/18/2014)... October 18, 2014 The report ... Trends and Forecasts to 2019", analyzes the global ... order to understand the industry details such as ... across various geographic regions. , Browse 81 Market ... Slides and in-depth TOC on “1,6-Hexanediol Market by ...
Breaking Biology Technology:Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 51,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
... medium, just like the roads and all the highways. Somehow there ... some drive taxis, others drive Ferraris orrace tractor-trailers. To each his ... heaven. , ,This brings us to two main points, why is ... 90 percent of the technology marketing increasingly poor? Is it because ...
... Renaissance Learning, Inc. , has agreed to acquire ... learning devices for K-12 students, for $57 million. , ... the AlphaSmart name and operate the company as a ... share in the deal, which is expected to be ...
... new secretary of commerce ,Wisconsin Governor Jim Doyle has ... of forecasting and planning for Trek Bicycles , to ... predecessor, Cory Nettles, stepped down at the end of 2004 ... contest deadline is January 31 ,Governor Doyle's business-plan contest ...
Cached Biology Technology:Global Internet branding of technology companies 2Global Internet branding of technology companies 3
Cytofix Buffer 100 mls...
Rabbit polyclonal to JAK1 (phospho Y1022 + Y1023) ( Abpromise for all tested applications). entrezGeneID: 3716 SwissProtID: P23458...
Perm/Wash Buffer 250 Tests...
PCR purification kit, 100 preps...
Biology Products: