Navigation Links
New methods for quantifying antisense drug delivery to target cells and tissues
Date:2/1/2013

New Rochelle, NY, January 31, 2012Powerful antisense drugs that target disease-associated genes to block their expression can be used to treat a broad range of diseases. Though antisense therapy has been proven effective, challenges remain in ensuring that the drugs reach their intended targets. Two new methods for detecting and measuring the levels of antisense drugs in cells that could accelerate the development of improved antisense drugs are described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available on the BioResearch Open Access website.

In the article "Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells," Frederick Schnell, Stacy Crumley, Dan Mourich, and P.L. Iversen, from Sarepta Therapeutics and Oregon State University (Corvallis, OR), describe two fast and sensitive methods for detecting a promising type of antisense therapeutic called a phosphorodiamidate morpholine oligomer, or PMO. Using these novel methods they were able to detect PMO delivery to individual cells and quantify how much PMO resides in a particular tissue in the body, such as the lung. For example, the authors describe the measurement of intranasally delivered PMO in lung tissue and, more specifically, in different cell types in the lung. They were able to measure the clearance kinetics of the PMO and determine whether it stayed in the lung tissue.

"The development of novel, rapid PMO detection techniques such as these will advance the field of PMO research in a significant way, providing valid alternatives to the current time-consuming and l
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New methods for better purification of wastewater
2. Chilling methods could change meat tenderness
3. Scientists from Bangalore and Mainz develop new methods for cooling of ions
4. ARS scientists test improved stink bug trapping methods
5. Risks and rewards of quantifying natures ecosystem services
6. Quantifying corn rootworm damage
7. From the Amazon rainforest to human body cells: Quantifying stability
8. Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells
9. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
10. Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
11. Light-induced delivery of nitric oxide eradicates drug-resistant bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New methods for quantifying antisense drug delivery to target cells and tissues
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this market is ... Chemical sensors help in recording of patient data for ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used for the ... facial feature of a person such as nose, jaw ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... have usually quite strong memories of past events like an ... not clear how the brain keeps track of the temporal ... wine before or after Mary left the party? , ... at the University of Lübeck have confirmed the widely held ...
... in the human vagina have been definitively identified in ... of the journal Immunity, published by Cell Press. The ... that will prevent HIV-1 transmission. , "The majority ... HIV infection following sexual contact," explain study authors Dr. ...
... impressive result of a study carried out by a group ... the Mario Negri Institute in Milan, Italy in cooperation with ... The study appears in the April 18th issue of the ... Science, PLoS ONE. , Stroke is the first cause of ...
Cached Biology News:Researchers discover new details about HIV-1 entry and infection 2
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval application ... the use of Medtronic,s SynchroMed ® II implantable ... use with United Therapeutics, Remodulin ® (treprostinil) Injection ...
(Date:12/24/2014)... 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... clinical grade hypothermic storage and cryopreservation freeze ... cells and tissues  ("BioLife" or the "Company"), today announced that ... May 4, 2015 (the "Annual Meeting"). Because the ...
(Date:12/24/2014)... December 23, 2014 Earlier this year in ... director of the Adult Stem Cell Technology Center, LLC ( ... appreciated unique property of adult tissue stem cells. His ... Past, Important for the Future,” embodied the essence of his ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... expansion, interactive healthcare marketing agency continues to ... grow top strategic talent ... Cadient Group, the,premier independent interactive marketing agency serving the ... "We,re grateful for each of these senior executives, contributions ...
... Pharmion Corporation,(Nasdaq: PHRM ) today reported financial results ... the year, net sales totaled $267.3 million,compared to net ... (azacitidine for injection) totaled $165.3 million for 2007,compared to ... Vidaza totaled,$131.4 million in 2007, compared to $130.6 million ...
... 19 Onyx,Pharmaceuticals, Inc. (Nasdaq: ONXX ) today ... provide an update on Nexavar(R),(sorafenib) tablets, as well as ... on Tuesday, February 19, 2008, at 10:00 a.m.,Eastern Time ... and year ended December 31, 2007 will be released ...
Cached Biology Technology:Cadient Group Announces Recent Executive Promotions 2Pharmion Corporation Announces 2007 Operating Results 2Pharmion Corporation Announces 2007 Operating Results 3Pharmion Corporation Announces 2007 Operating Results 4Pharmion Corporation Announces 2007 Operating Results 5Pharmion Corporation Announces 2007 Operating Results 6Onyx Pharmaceuticals Announces a Teleconference and Webcast to Provide an Update on Nexavar and Report Full Year 2007 Financial Results 2
... Instrument System is ideal for developing ... Beadlyte reagents. The Luminex 100 Instrument ... software version 1.7, the XY platform ... offers $2000 in free Beadlyte products ...
Peptide-affinity Purified Polyclonal Antibody to ICEBERG Peptide with sequence EEDPQLASKMGLH, from C Terminus of the protein sequence according to NP_067546...
A431 cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Madin-Darby bovine kidney (MDBK) cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: