Navigation Links
New method for uncovering side effects before a drug hits the market
Date:1/2/2013

Side effects are a major reason that drugs are taken off the market and a major reason why patients stop taking their medications, but scientists are now reporting the development of a new way to predict those adverse reactions ahead of time. The report on the method, which could save patients from severe side effects and save drug companies time and money, appears in ACS' Journal of Chemical Information and Modeling.

Yoshihiro Yamanishi and colleagues explain that drug side effects are a major health problem the fourth-leading cause of death in the U.S. which by some estimates claim 100,000 lives every year. Serious side effects are the main reason why existing drugs must be removed from the market and why pharmaceutical companies halt development of new drugs after investing millions of dollars. Current methods of testing for side effects are costly and inaccurate. That's why the scientists sought to develop a new computer-based approach to predicting possible side effects.

They show the usefulness of their proposed method on simultaneous prediction of 969 side effects of 658 drugs that already are in wide medical use. The method is based on knowledge about chemical and biological information about ingredients in these medications. They also used the approach to identify possible side effects for many uncharacterized molecules. Based on that work, the scientists conclude that the new method could be helpful in uncovering serious side effects early in the development and testing of new drugs, avoiding costly investment in medications unsuitable for marketing.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers develop tool to evaluate genome sequencing method
2. Improving the development of new cancer models using an advanced biomedical imaging method
3. Scientists develop novel method to study parasite numbers in wild seabirds
4. New method for creating long-lived stem cells used for bone replacement
5. Salk scientists develop faster, safer method for producing stem cells
6. New method for diagnosing malaria
7. Scientists from Bangalore and Mainz develop new methods for cooling of ions
8. Scientists discover new method of gene identification
9. A new computational method for timing the tree of life
10. Texas Biomed reports faster, more economical method for detecting bioterror threats
11. Temporary storage for electrons: Natural method of producing hydrogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)...  Aware, Inc. (NASDAQ: AWRE ), a leading ... for its quarter and year ended December 31, 2016. ... $3.9 million compared to $6.9 million in the same quarter ... was $0.6 million compared to $2.6 million in the fourth ... 2016 was $0.5 million, or $0.02 per diluted share, which ...
(Date:2/7/2017)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that the latest release ... flexible and award winning eClinical solution, is now available ... is a proven Software-as-a-Service (SaaS) clinical research technology platform ... also delivers an entire suite of eClinical tools to ...
(Date:2/3/2017)... , Feb. 3, 2017  Texas Biomedical Research Institute ... Larry Schlesinger as the Institute,s new President ... Biomed effective May 31, 2017. He is currently the Chair ... of the Center for Microbial Interface Biology at Ohio State ... as the new President and CEO of Texas Biomed," said ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... , ... February 21, 2017 , ... ... organizations to build connected digital health applications, announced a partnership with Redox, a ... to seamlessly connect to many clinical systems while keeping data secure in the ...
(Date:2/21/2017)... ... February 21, 2017 , ... Genedata, a leading provider ... announced the establishment of Genedata Limited as a new subsidiary in the United ... in life science informatics. Creating the UK subsidiary reinforces Genedata’s commitment to collaborate ...
(Date:2/21/2017)... ... February 21, 2017 , ... The medical potential of stem cells is both ... of medicine, due to their differentiating characteristics. Stem cells are unique as the have ... be induced to become tissue or organic-specific cells with special functions. , Stem ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... manufacturing facility at its headquarters laboratory in Poway, California. Based upon 12 ... of both in-house personnel and consultants, VetStem constructed and validated a state-of-the-art GMP ...
Breaking Biology Technology: