Navigation Links
New method for uncovering side effects before a drug hits the market
Date:1/2/2013

Side effects are a major reason that drugs are taken off the market and a major reason why patients stop taking their medications, but scientists are now reporting the development of a new way to predict those adverse reactions ahead of time. The report on the method, which could save patients from severe side effects and save drug companies time and money, appears in ACS' Journal of Chemical Information and Modeling.

Yoshihiro Yamanishi and colleagues explain that drug side effects are a major health problem the fourth-leading cause of death in the U.S. which by some estimates claim 100,000 lives every year. Serious side effects are the main reason why existing drugs must be removed from the market and why pharmaceutical companies halt development of new drugs after investing millions of dollars. Current methods of testing for side effects are costly and inaccurate. That's why the scientists sought to develop a new computer-based approach to predicting possible side effects.

They show the usefulness of their proposed method on simultaneous prediction of 969 side effects of 658 drugs that already are in wide medical use. The method is based on knowledge about chemical and biological information about ingredients in these medications. They also used the approach to identify possible side effects for many uncharacterized molecules. Based on that work, the scientists conclude that the new method could be helpful in uncovering serious side effects early in the development and testing of new drugs, avoiding costly investment in medications unsuitable for marketing.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers develop tool to evaluate genome sequencing method
2. Improving the development of new cancer models using an advanced biomedical imaging method
3. Scientists develop novel method to study parasite numbers in wild seabirds
4. New method for creating long-lived stem cells used for bone replacement
5. Salk scientists develop faster, safer method for producing stem cells
6. New method for diagnosing malaria
7. Scientists from Bangalore and Mainz develop new methods for cooling of ions
8. Scientists discover new method of gene identification
9. A new computational method for timing the tree of life
10. Texas Biomed reports faster, more economical method for detecting bioterror threats
11. Temporary storage for electrons: Natural method of producing hydrogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... the repeated climatic shifts over the last 120,000 ... diversity, a team of researchers led by City ... developed a new biodiversity metric called "phylogeographic endemism." ... genetic variation within species is restricted in geographical ... biology, and 14 other researchers from institutions in ...
(Date:8/29/2014)... of marine phytoplankton, such as the prolific bloomer ... (thiamine), researchers have discovered. The finding contradicts the common ... eukaryotic microbes depend on scarce supplies of thiamine in ... way to think about the ocean," says CIFAR Senior ... ISME Journal paper with CIFAR fellows John ...
(Date:8/28/2014)... TX Invasives is now available from the Lady Bird ... Austin for identifying harmful non-native plant, insect and other ... United States cause about $137 billion in economic and ... waterways, kill native plants and more. , "By having ... where invasive species occur, we,re more likely to catch ...
Breaking Biology News(10 mins):CCNY team defines new biodiversity metric 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... green chemical technologies will play a key role helping ... a wider range of products from biorefineries, according to ... Director of the University,s Green Chemistry Centre of Excellence, ... the American Association for the Advancement of Science (AAAS) ...
... Feb. 18, 2011 USDA,s National Institute of Food ... (CAP) representing a major scientific investment in studying the ... NIFA Director Roger Beachy made the announcement today at ... Advancement of Science in Washington, D.C. "Climate change ...
... the first time been cloned as seeds. The research by ... 18 in the journal Science , is a major ... traits from generation to generation. Most successful crop ... biology at UC Davis and an author of the paper. ...
Cached Biology News:NIFA announces grants to study the effects of climate change on agricultural and forest production 2NIFA announces grants to study the effects of climate change on agricultural and forest production 3Plants cloned as seeds 2
(Date:8/27/2014)... YORK , Aug. 27, 2014 /PRNewswire/ ... research report is available in its catalogue: ... 2014-2018 http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials are materials that are readily decomposed ... differs from conventional non-degradable packaging in terms ...
(Date:8/27/2014)... nature,s mysteries is how plants survive impact by ... sun,s rays, while using this energy for photosynthesis. ... the plant,s blades quickly dissipate the energy throughout ... Researchers at DTU Physics have now managed to ... and bacteria contain light-absorbing proteins which play a ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Global Chelating Agents ... About Chelating Agent A chelating agent ... bonds with metal ions, thereby forming a metal-ion ... metal-ions have on chemical processes, formulations, and the ...
(Date:8/27/2014)... , Aug. 27, 2014  Lisa Kulik saw ... this July 4 holiday, thanks to a groundbreaking retinal ... an internationally renowned clinician-researcher at the University of Southern ... 55-year-old Peoria, Ariz. resident who ... its victims of sight. On June 2, she became ...
Breaking Biology Technology:Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7DTU researchers film protein quake for the first time 2Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5
... Collaborative for Healthcare Quality has been chosen to lead ... settings, but participation will not necessarily be based on the ... a federal pilot project to develop a practical method of ... a format that is useful to both physicians and consumers. ...
... Berbee Information Networks Corporation said ... communications partner of the year for 2005. , ... related to Berbee's sales and support of Cisco ... Cisco practice, said it's the firm's fifth straight ...
... his keynote at the Fusion2006 CEO-CIO Symposium , WTN caught ... outsourcing and when it's a good idea. Read part one ... way of distributing the risk of development to other organizations. But ... , , Koulopoulos Koulopoulos: Probably the second ...
Cached Biology Technology:Healthcare quality initiative shuns high-tech for now 2IT outsourcing according to Tom Koulopoulos, part 2 2IT outsourcing according to Tom Koulopoulos, part 2 3IT outsourcing according to Tom Koulopoulos, part 2 4
... platform, 220 V, is used for agitation and ... cultures, staining and destaining of gels and blots, ... control (8-40 rpm) and can handle a maximum ... features two 29 x 21 cm platforms covered ...
...
...
... of Wyatt Technology's family of light scattering ... high temperature chromatograph and enables you to ... polymers. The HTmD is easily installed in ... or Alliance 2000 device and enables you ...
Biology Products: