Navigation Links
New method for diagnosing malaria
Date:11/27/2012

Malaria is a life-threatening disease that strikes more than 200 million people every year mainly in Africa, Asia and Latin America. The disease is caused by the Plasmodium parasite, which is spread by infected mosquito bites. Today, malaria can be prevented and successfully treated, but more than half a million people nevertheless die every year from the disease.

Large-scale monitoring and treatment programmes during the past decade have reduced the distribution of the disease, and the frequency of actual epidemics has fallen. However, the number of malaria patients with relatively low infection counts has increased, and the need for more sensitive methods to diagnose the disease has thus increased dramatically.

Development of new, simple and sensitive method

To meet this need, researchers at Aarhus University have developed a new method that can diagnose malaria infections with very high sensitivity. The method is based on measuring the activity of an enzyme called topoisomerase I from the Plasmodium parasite.

The researchers have developed a technology called REEAD (Rolling Circle-Enhanced Enzyme Activity Detection) which makes it possible to diagnose malaria from a single drop of blood or saliva. This method is much more time-effective and cost-effective than current diagnostic methods, and can be performed by personnel who have no specialised training. It can therefore be used in low-resource areas without the use of expensive equipment, clean water or electricity.

The ongoing fight against malaria is complicated by increasing problems with resistant Plasmodium parasites. In addition, several Plasmodium species (P. vivax and P. knowlesi) cannot be detected with the usual quick-test methods.

The new REEAD-based method distinguishes itself from other quick-test methods because it can measure whether a given Plasmodium infection is resistant to drugs. The newly developed technology is also the only quick-test method that makes it possible to diagnose the less common malaria parasites (P. ovale, P. knowlesi and P. malariae) in addition to the most common Plasmodium parasites (P. falciparum and P. vivax).

The unique sensitivity, combined with its ability to detect infection in very small samples of blood or saliva, makes the method suitable for large-scale screening projects. This is of great importance in areas where the disease is close to being eradicated, and where it is therefore essential to identify and treat all patients infected with one of the above-mentioned parasites even those who do not show symptoms of the disease.

Interdisciplinary, international collaboration

"This combination of molecular biologists, doctors, engineers and statisticians has been important for our success in developing the new method," says Associate Professor Birgitta Knudsen, who is the driving force behind the project.


'/>"/>

Contact: Birgitta R. Knudsen
brk@mb.au.dk
45-60-20-26-73
Aarhus University
Source:Eurekalert  

Related biology news :

1. Scientists from Bangalore and Mainz develop new methods for cooling of ions
2. Scientists discover new method of gene identification
3. A new computational method for timing the tree of life
4. Texas Biomed reports faster, more economical method for detecting bioterror threats
5. Temporary storage for electrons: Natural method of producing hydrogen
6. USDA patents method to reduce ammonia emissions
7. New NIST screening method identifies 1,200 candidate refrigerants to combat global warming
8. Chemists develop reversible method of tagging proteins
9. Researchers develop rapid method to measure carbon footprints
10. Chilling methods could change meat tenderness
11. New DNA-method tracks fish and whales in seawater
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New method for diagnosing malaria
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight Medical ... to the healthcare market. The company's primary focus is on new product introductions, ... strategies that are necessary to help companies efficiently bring their products to market. ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
Breaking Biology Technology: