Navigation Links
New mechanism for protein misfolding may link to ALS
Date:9/28/2013

Proteins play important roles in the human body, particularly neuroproteins that maintain proper brain function.

Brain diseases such as ALS, Alzheimer's, and Parkinson's are known as "tangle diseases" because they are characterized by misfolded and tangled proteins which accumulate in the brain.

A team of Australian and American scientists discovered that an unusual amino acid called BMAA can be inserted into neuroproteins, causing them to misfold and aggregate. BMAA is produced by cyanobacteria, photosynthetic bacteria that form scums or mats in polluted lakes or estuaries.

BMAA has been detected in the brain tissues of ALS patients.

In an article published in PLOS ONE scientists at the University of Technology Sydney and the Institute for Ethnomedicine in Jackson Hole, Wyoming, report that BMAA mimics a dietary aminoacid, L-Serine, and is mistakenly incorporated into neuroproteins, causing the proteins to misfold. The misfolded proteins build up in cells, eventually killing them.

"We found that BMAA inserts itself by seizing the transfer RNA for L-Serine. This, in essence, puts a kink in the protein causing it to misfold," says lead author Dr. Rachael Dunlop, a cell biologist in Sydney working in the laboratory of Dr. Ken Rodgers.

"The cells then begin programmed cell death, called apoptosis. "Even more importantly, the scientists found that extra L-Serine added to the cell culture can prevent the insertion of BMAA into neuroproteins. The possibility that L-Serine could be used to prevent or slow ALS is now being studied."

Even though L-serine occurs in our diet, its safety and efficacy for ALS patients should be properly determined through FDA-approved clinical trials before anyone advocates its use," says American co-author Dr. Paul Cox.

In ALS, motor neurons in the brain and spinal cord die, progressively paralyzing the body until even swallowing and breathing becomes imp
'/>"/>

Contact: Marilyn Asay
marilyn@ethnomedicine.org
801-375-6214
University of Technology Sydney
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mechanism for Burgess Shale-type preservation
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
4. Researchers unravel genetic mechanism of fatty liver disease in obese children
5. Mechanism found connecting metastatic breast cancer and arthritis
6. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
7. New genetic mechanism of immune deficiency discovered
8. Housekeeping mechanism for brain stem cells discovered
9. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
10. Researchers find mechanism that gives plants balance
11. New key mechanism in cell division discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... TRIANGLE PARK, N.C. , Feb. 5, 2015 /PRNewswire/ ... a specialist logistics company and has launched a new ... only Clinical Logistics Organization (CLO).  The new campaign focuses ... emphasis on patient, protocol and shipments. The ... First , aligns Marken,s priorities with its client,s ...
(Date:2/5/2015)... Conn. , Jan. 26, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... new corporate website ( http://www.nxt-id.com/ ) as part of ... smart wallet. The Company launched its new consumer website ... Gino Pereira , CEO of NXT-ID said, "Our new ...
(Date:2/5/2015)... SAN FRANCISCO , January 28, 2015 ... Camera Market Analysis, Size And Segment Forecasts To 2020 ... The global IR camera market is expected to reach ... study by Grand View Research, Inc. IR cameras help ... injuries, and are expected to witness surging demand in ...
Breaking Biology News(10 mins):Marken Launches New Patient-Centric Campaign 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3
... some of the most pressing international issuessuch as renewable ... more pressing than ever that an informed public be ... science. The Ecological Society of America (ESA),s 93rd Annual ... the importance of using a broad range of tools ...
... Montana State University microbiologist Matthew Fields spends his days ... granted. Fields studies the physiology and behavior of ... every square inch of the earth,s surface for the ... impact," Fields said. "They grow fast and in large ...
... factors can transform the ratio of females to males in ... of Toronto. The study conducted ... and Spencer Barrett, a professor, involved a novel approach using ... seeds. The team investigated six natural populations of the wind-pollinated ...
Cached Biology News:Training future scientists at the Ecological Society of America's 93rd Annual Meeting 2MSU researcher uses grant to study little-known but largely useful microbes 2
(Date:2/27/2015)... 2015 Bionomics Limited (ASX:BNO, ADR:BMICY) is to ... BNC105 in patients with metastatic renal cancer at the ... . The data will be presented by Dr. ... Comprehensive Cancer Center in California ... data identifies Ferritin and IL-8 as two baseline biomarkers ...
(Date:2/27/2015)... , Feb. 27, 2015  Steep Hill, the industry ... and internationally, intends to open a full service medical ... Mexico , bringing advanced scientific tools and methodology ... Steep Hill is currently the only laboratory licensed ... potency and contaminant testing in order to meet the ...
(Date:2/26/2015)... , Feb. 26, 2015  23andMe, the leading ... Kate Black as Privacy Officer and Corporate Counsel. ... state privacy laws as well as health care regulations. ... she will be responsible for reviewing, updating and enhancing ... the U.S. and abroad. She joined the company January ...
(Date:2/26/2015)... 26, 2015 Protiviti ( www.protiviti.com ), a ... the Governance Portal , designed to increase the ... (GRC) tasks across multiple business units and projects. The ... customers better align their controls with the COSO ( ... requirements. In response to client feedback, Protiviti has also ...
Breaking Biology Technology:New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 223andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3
... fibers that are only one-tenth the size of a ... hold up to the intense heat and radiation of ... The Gen IV power-generating reactors are being designed to ... current reactors do not have. , The Department ...
... and scale of EDS services allow Bristol-Myers Squibb to ... focus on core biopharmaceutical business, ... million information technology (IT) services contract that,calls for EDS to ... scope and scale will allow the company to,improve productivity so ...
... and Tactical Importance of ... Needle-less Vaccinations, ... the DelSite Biotechnologies subsidiary of,Carrington Laboratories, Inc. (OTC Bulletin Board: ... program, while greatly,expanding the use of needle-less vaccines here and ...
Cached Biology Technology:Clemson researcher studies carbon fibers for nuclear reactor safety 2EDS Awarded $715 Million Contract for Bristol-Myers Squibb Information Services 2EDS Awarded $715 Million Contract for Bristol-Myers Squibb Information Services 3DelSite Nasal Powder Technology Could Reduce Recently Reported Waste in Federal Vaccine Program 2DelSite Nasal Powder Technology Could Reduce Recently Reported Waste in Federal Vaccine Program 3
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Human LT beta R/TNFRSF3 Phycoerythrin MAb (Clone 71319)...
Human Serpin A3 MAb (Clone 213907)...
Biology Products: