Navigation Links
New measurement of telomeres; DNA could help identify most viable embryos for IVF
Date:6/28/2010

Scientists from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust, are the first to directly measure a specific region of DNA in human embryos. The length of this region could be a quality marker for embryonic development.

Researchers at the University of Warwick's Warwick Medical School and University Hospital, Coventry, have measured telomeres, regions of repetitive DNA at the ends of a chromosome which protect it from deterioration. Telomeres shorten each time a cell divides and when telomere length becomes critically short, the cells die.

The research, published in Molecular Human Reproduction Journal, suggests that telomere length is shortest in the early stages of an embryo's development, at around two days, and then lengthens just before implantation in the womb at five days. This lengthening may be essential for normal development, because short telomeres may not be enough to survive the many rounds of cell division that take place as embryos grow.

Lead authors Professor Geraldine Hartshorne, from the University of Warwick's Warwick Medical School, and Sarah Turner, from University Hospital , Coventry, said this discovery could have implications for IVF treatment.

Professor Hartshorne said: "It has already been shown that artificially shortened telomeres cause problems in animal embryos. Human embryos are highly variable, and many of them cannot develop normally. We think that telomere length might one day be used to help diagnose which are the most viable embryos. We also know that telomeres shorten with oxidative stress, so telomere length might also provide a measure of the stressfulness of the culture systems that we use in IVF and their impact on embryos."

The research project used oocytes and embryos donated by patients undergoing IVF treatment. Only material that could not be used for the patients' own treatment was accessed for research.

Sarah Turner
'/>"/>

Contact: Peter Dunn
p.j.dunn@warwick.ac.uk
44-247-652-4668
University of Warwick
Source:Eurekalert

Page: 1 2

Related biology news :

1. Unprecedented global measurement network achieves full coverage of oceans
2. Measurement Specialties, Inc. Announces Impact of German Business Tax Reform 2008 Resulting in Lower Combined German Tax Rate - Impacts 2Q08 Reported Financial Results
3. Worldwide atmospheric measurements will determine the role of atmospheric fine particles
4. LDL particle measurement by NMR recognized by ADA, ACC
5. Scientists demonstrate the sharpest measurement of ice crystals in clouds
6. Successful series of measurements in Arctic sea ice
7. UI researchers help to improve carbon measurements in global climate studies
8. Carbon accounting from atmospheric measurements -- the aircraft perspective
9. Innerscope Research Adds to Its Advisory Board Two Pioneers in the Measurement and Application of Emotional Engagement
10. NIST issues human milk and blood serum SRMs for contaminant measurements
11. Innerscope Research Adds to Its Advisory Board Two Pioneers in the Measurement and Application of Emotional Engagement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... From far away, the top of a leaf looks ... exterior is actually made up of a patchwork of ... in how these cells individually take on their own ... Sampathkumar, and colleagues sought to pinpoint the shape-controlling factors ...
(Date:4/16/2014)... muscular atrophy (SBMA) is a rare inherited neuromuscular disorder characterized ... considered it to be essentially an affliction of primary motor ... that control muscle movement. , But in a new study ... Neuron , a team of scientists at the University of ...
(Date:4/16/2014)... director of the Physical Biosciences Division of Lawrence Berkeley ... recognized as a leading authority on the evolutionary design ... to systems and synthetic biology, has been named one ... Award by U.S. Energy Secretary Ernest Moniz. The E.O. ...
Breaking Biology News(10 mins):For cells, internal stress leads to unique shapes 2Mutant protein in muscle linked to neuromuscular disorder 2Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 2Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 3
... University of Wisconsin School of Medicine and Public Health ... taking part in a novel clinical trial investigating if ... of severe coronary artery disease. , The trial, just ... in the Autologous Cellular Therapy CD34-Chronic Myocardial Ischemia (ACT34-CMI) ...
... but also too much iron is bad for our ... where it can lead to organ failure and even ... Researchers from the Innsbruck Medical University, the University of ... now made a surprising discovery that may lead to ...
... play a pivotal role in the inception of Darwin’s theory ... their significance when he collected them during his voyage on ... predict the impact the vast amount of marine microbial DNA ... J. Craig Venter, Ph.D., and his team ?will have on ...
Cached Biology News:UW launches study testing adult stem cells for heart damage repair 2UW launches study testing adult stem cells for heart damage repair 3Putting an old drug to a new use 2Darwin's famous finches and Venter's marine microbes 2Darwin's famous finches and Venter's marine microbes 3Darwin's famous finches and Venter's marine microbes 4Darwin's famous finches and Venter's marine microbes 5
(Date:1/15/2014)... Ill. , Jan. 15, 2014  Bill Jacobs Automotive, a ... , is teaming up with the Heartland Blood Center and ... blood drive. The drive takes place Saturday, Jan. 18 at ... - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... and SAN JOSE, California , January 15, ... developing antibody-drug conjugates for cancer, today announced the appointment of ... Dr Reynolds has over 20 years, development experience gained in ... Seattle Genetics. "I am delighted to welcome Tom ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... January 15, 2014 AudioNotch is the ... therapy for the treatment of tinnitus. Patients listen to ... and over a period of weeks to months, their tinnitus ... in two forms: Notched Music and Notched White Noise. Now, ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... of Angel Soft website Madison, Wis. Imagine, says ... that you actually want to watch it again and again. ... Soft toilet paper by international tissue and paper manufacturer Georgia-Pacific. ... asks him what he is doing," Ramsey told a crowd ...
... exceeded expectations, reaching $3.6 billion in 2002, according to a new ... 2005. , ,In 2002, the state ranked 20 th ... in academic R&D spending. , ,"You'd be hard-pressed to find ... few years," said David Ward, president of NorthStar Economics ...
... has announced the release of Centricity Physician Office ... for physicians that extends the functionality of Centricity Physician ... , , Centricity Physician Office Mobile ... and schedules and to capture charges from any location. ...
Cached Biology Technology:Consumer "engagement" stressed at e-Business seminar 2Consumer "engagement" stressed at e-Business seminar 3New report says Wisconsin R&D spending exceeding expectations 2
... This complete kit contains enough ... from a total of 5 ... and includes the StemSep red ... reagents and buffers for the ...
... The EZ DNA Methylation Kit uses a ... for DNA methylation analysis. The kit is ... takes place between cytosine and sodium bisulfite ... EZ DNA Methylation Kits innovative in-column desulphonation ...
... Product Mouse monoclonal [1320] to RFC1 ... subunit of human Replication Factor C expressed in ... with Human and S. cerevisiae. Not yet tested ... subunit of RFC1 Background Information ...
... enzyme glycerol 3-phosphate dehydrogenase catalyzes a ... and glycerol 3-phosphate, with NAD as ... during differentiation of progenitor cells into ... this enzyme has been used as ...
Biology Products: