Navigation Links
New lung cancer study takes page from Google's playbook
Date:3/25/2013

SAN DIEGO - The same sort of mathematical model used to predict which websites people are most apt to visit is now showing promise in helping map how lung cancer spreads in the human body, according to a new study published in the journal Cancer Research.

A team of researchers used an algorithm similar to the Google PageRank and to the Viterbi Algorithm for digital communication to analyze the spread patterns of lung cancer. The team includes experts from the University of Southern California (USC), Scripps Clinic, The Scripps Research Institute, University of California, San Diego Moores Cancer Center and Memorial Sloan-Kettering in New York.

"This research demonstrates how similar the Internet is to a living organism," said USC Viterbi School of Engineering Professor Paul Newton, Ph.D., the lead and corresponding author of the study. "The same types of tools that help us understand the spread of information through the web can help us understand the spread of cancer through the human body."

Employing a sophisticated system of mathematical equations known as a Markov chain model, the research team guided by USC applied mathematicians found that metastatic lung cancer does not progress in a single direction from primary tumor site to distant locations, which has been the traditional medical view. Instead, they found that cancer cell movement around the body likely occurs in more than one direction at a time.

Researchers also learned that the first site to which the cells spread plays a key role in the progression of the disease. The study showed that some parts of the body serve as "sponges" that are relatively unlikely to further spread lung cancer cells to other areas of the body. The study identified other areas as "spreaders" for lung cancer cells.

The study revealed that for lung cancer, the main spreaders are the adrenal gland and kidney, whereas the main sponges are the regional lymph nodes, liver and bone.

The study applied the advanced math model to data from human autopsy reports of 163 lung cancer patients in the New England area, from 1914 to 1943. This time period was targeted because it predates the use of radiation and chemotherapy, providing researchers a clear view of how cancer progresses if left untreated. Among the 163 patients, researchers charted the advancement patterns of 619 different metastases to 27 distinct body sites.

The study's findings could potentially impact clinical care by helping guide physicians to targeted treatment options, designed to curtail the spread of lung cancer. For example, if the cancer is found to have moved to a known spreader location, imaging tests and interventions can be quickly considered for focused treatment before the cells may be more widely dispersed. Further study is needed in this area.

Keeping tabs on cancer's movement in the body is vital to patient care. While a primary cancer tumor (confined to a single location) is often not fatal, a patient's prognosis can worsen if the cancer metastasizes that is, flakes off and travels to other parts of the body to form new tumors.

The study is part of a relatively new movement to involve physical sciences in oncology research. Mathematics probability models that interpret data from specific patient populations offer a new alternative to the established approach of relying on broader clinical trends to predict where, and how fast, cancer will spread.


'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Embryonic development protein active in cancer growth
3. BRG1 mutations confer resistance to hormones in lung cancer
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Beyond the microscope: Identifying specific cancers using molecular analysis
6. Marshall University study may lead to new treatments for prostate cancer
7. Salk scientists open new window into how cancers override cellular growth controls
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Genetic abnormality offers diagnostic hope for childrens cancer
10. Protein jailbreak helps breast cancer cells live
11. Breast cancer risk gene discovery fast tracked by new technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... the trading session at 4,833.32, down 0.22%; the Dow Jones ... the S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ... BIND Therapeutics Inc. (NASDAQ: BIND ). Learn more ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
Breaking Biology Technology: