Navigation Links
New key to organism complexity identified
Date:1/17/2013

The enormously diverse complexity seen amongst individual species within the animal kingdom evolved from a surprisingly small gene pool. For example, mice effectively serve as medical research models because humans and mice share 80-percent of the same protein-coding genes. The key to morphological and behavioral complexity, a growing body of scientific evidence suggests, is the regulation of gene expression by a family of DNA-binding proteins called "transcription factors." Now, a team of researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley has discovered the secret behind how one these critical transcription factors is able to perform a split personality.

Using a technique called single-particle cryo-electron microscopy, the team, which was led by biophysicist Eva Nogales, showed that the transcription factor known as "TFIID" can co-exist in two distinct structural states. These two states the canonical and the rearranged - differ only in the translocation of a single substructural element known as lobe A - by 100 angstroms (an atom of hydrogen is about one angstrom in diameter). This structural shift enables initiation of the transcription process by which the genetic message of DNA is copied to RNA for the eventual production of proteins.

"TFIID by itself fluctuates between the canonical and rearranged states," Nogales says. "When TFIID becomes bound to another transcription factor, TFIIA, it shifts mostly to the canonical state, but in the presence of both TFIIA and DNA, the TFIID shifts to the rearranged state, which enables recognition and binding to key DNA sequences and marks the start of the transcriptional process."

Understanding the reorganization of TFIID and its role in transcription provides new insight into the regulation of gene expression, Nogales says, a process critical to the growth, development, health and sur
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Production of 5-aminovaleric and glutaric acid by metabolically engineered microorganism
2. Keeping ship hulls free of marine organisms
3. Hearty organisms discovered in bitter-cold Antarctic brine
4. Strange diet for methane consuming microorganisms
5. Plants recognise pathogenic and beneficial microorganisms
6. Small marine organisms big changes could affect world climate
7. Small organisms could dramatically impact worlds climate
8. Unusual symbiosis discovered in marine microorganisms
9. New research suggests bacteria are social microorganisms
10. Why do organisms build tissues they seemingly never use?
11. Progress of arachidonic acid biosynthesis in microorganisms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New key to organism complexity identified
(Date:7/2/2015)... 25, 2015 Research ... of the "Natural Language Processing Market by ... OCR, Pattern & Image Recognition) - Worldwide Forecast ... The key vendors occupying the market are ... Microsoft Corporation, NetBase Solutions, SAS Institute Inc., Verint ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) ... Biometrics Market by Application, Technology, Function & Geography - ... The next generation biometrics market is expected ... of 17.9% between 2015 and 2020 Travel ... Safran SA ( France ), ...
(Date:7/2/2015)... GOTHENBURG, Sweden , July 2, 2015 ... fingerprint sensors FPC1025, FPC1035, FPC1145 and FPC1155 from the distributor ... is one of FPC,s distributors in Asia ... Q4 2015. The sensors will be used by smartphone manufacturers ... 268 MSEK is included in the communicated revenue guidance of ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... An international team of researchers has identified a novel ... a new study published online the week of April ... of Sciences . The study advances our ... behavior. Study contributors Danielle M. Dick, Ph.D., associate ...
... leatherback sea turtle nests at 68 beaches in Florida has ... a new Duke University-led study published in the current issue ... posted annual increases of more than 16 percent, others as ... nests in the Sunshine State mirrors trends observed for other ...
... N.C. Tree growth and fecundity the ability to ... change than previously thought, according to an 18-year study ... The study, published April 5 in Global Climate ... several overlooked factors that affect tree reproduction and growth, ...
Cached Biology News:Gene involved in predisposition to alcohol consumption identified 2Leatherback sea turtle nests increasing in Florida 2'Epidemiological' tree study shows impacts of climate change on forests 2
(Date:7/2/2015)... Amici Procurement Migrates to the ... Procurement has chosen Microsoft Cloud Solution Provider iomart ... 365.      (Logo: http://photos.prnewswire.com/prnh/20121126/579634) , ... in the bio-tech sector with a unique procurement service, ... to help them obtain best value. Its IT platform ...
(Date:7/2/2015)... ... 2015 , ... In’Tech Medical SAS ( http://www.intech-medical.com ), a ... the acquisition of Turner Medical, Inc ., thus becoming a global leader ... Spine Industry. The acquisition of Turner Medical ideally supplements In’Tech Medical’s product offering, ...
(Date:7/1/2015)... TRIANGLE PARK, N.C. and ... agricultural research firm AgBiome, and Genective, key developer ... to accelerate the discovery of new generations of ... traits for insect control to counter the realities ... partner with Genective, aligning AgBiome,s unique insect control ...
(Date:7/1/2015)... ... July 01, 2015 , ... The next-generation sequencing (NGS) clinical market is ... the molecular diagnostics industry. BCC Research reveals in its new report that the market ... costs, and a growing need for better diagnostics as part of a molecular diagnostics ...
Breaking Biology Technology:Biotech Procurement Company Moves to Office 365 with iomart 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3AgBiome and Genective collaborate to create novel insect-resistant crops 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3
... June 24, 2011 ,   ... no. 2511) investigated the efficacy and safety of,the ... patients. This study showed that in patients with,severe ... induction and,maintenance over a period of 18 months ...
... LONDON, June 24, 2011 ,   ... with The Royal British Legion by launching Poppy ... Poppy Online Saver is an ,easy ... penalty-free withdrawals are permitted each year, with,further withdrawals possible ...
... PHILADELPHIA When semiconductor nanorods are exposed to ... By clustering nanorods together, physicists at the University ... time is increased dramatically providing new insight into ... conducted by associate professor Marija Drndic,s group, including ...
Cached Biology Technology:ERA-EDTA Congress 2011: Late Breaking Clinical Trials I 2Coventry Launches Market Leading Online Savings Account With Added Poppy Appeal 2Coventry Launches Market Leading Online Savings Account With Added Poppy Appeal 3Penn physicists observe 'campfire effect' in blinking nanorod semiconductors 2Penn physicists observe 'campfire effect' in blinking nanorod semiconductors 3
... part 11, Compliant software for JASCO HPLC systems. , Integrated ... EZChrom ... software options for JASCO HPLC systems. This provides a completely integrated ... instrument settings with each run. , ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
... Spectrometry Applications ,In the age of ... as a powerful protein identification and characterization ... now an important intermediate step in a ... identification of specific proteins in the proteome ...
... Extraction Reagent is a liquid, ... means no scraping, no freeze-thaw ... M-PER Reagent, rapid lysis occurs ... room temperature, yielding 25% more ...
Biology Products: