Navigation Links
New key to organism complexity identified
Date:1/17/2013

The enormously diverse complexity seen amongst individual species within the animal kingdom evolved from a surprisingly small gene pool. For example, mice effectively serve as medical research models because humans and mice share 80-percent of the same protein-coding genes. The key to morphological and behavioral complexity, a growing body of scientific evidence suggests, is the regulation of gene expression by a family of DNA-binding proteins called "transcription factors." Now, a team of researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley has discovered the secret behind how one these critical transcription factors is able to perform a split personality.

Using a technique called single-particle cryo-electron microscopy, the team, which was led by biophysicist Eva Nogales, showed that the transcription factor known as "TFIID" can co-exist in two distinct structural states. These two states the canonical and the rearranged - differ only in the translocation of a single substructural element known as lobe A - by 100 angstroms (an atom of hydrogen is about one angstrom in diameter). This structural shift enables initiation of the transcription process by which the genetic message of DNA is copied to RNA for the eventual production of proteins.

"TFIID by itself fluctuates between the canonical and rearranged states," Nogales says. "When TFIID becomes bound to another transcription factor, TFIIA, it shifts mostly to the canonical state, but in the presence of both TFIIA and DNA, the TFIID shifts to the rearranged state, which enables recognition and binding to key DNA sequences and marks the start of the transcriptional process."

Understanding the reorganization of TFIID and its role in transcription provides new insight into the regulation of gene expression, Nogales says, a process critical to the growth, development, health and sur
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Production of 5-aminovaleric and glutaric acid by metabolically engineered microorganism
2. Keeping ship hulls free of marine organisms
3. Hearty organisms discovered in bitter-cold Antarctic brine
4. Strange diet for methane consuming microorganisms
5. Plants recognise pathogenic and beneficial microorganisms
6. Small marine organisms big changes could affect world climate
7. Small organisms could dramatically impact worlds climate
8. Unusual symbiosis discovered in marine microorganisms
9. New research suggests bacteria are social microorganisms
10. Why do organisms build tissues they seemingly never use?
11. Progress of arachidonic acid biosynthesis in microorganisms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New key to organism complexity identified
(Date:7/24/2014)... of researchers led by the University of York has ... in the Western Indian Ocean. , The results, ... to a revolution in the management of marine protected ... than 11,000 km in the region now under ... zones of the seas and coasts designed to protect ...
(Date:7/24/2014)... Singapore have developed Asia,s first genetic test for identifying ... the cornea called corneal stromal dystrophy which can lead ... the POLARIS TGFBI (Transforming Growth Factor beta Induced) test, ... diagnosis and management of patients with corneal stromal dystrophies. ... mutation who may also be at risk of developing ...
(Date:7/23/2014)... new study of identical twins has found that early ... study, in the journal Child Development , was ... King,s College London. , "Since reading is an ability ... reading instruction," according to Stuart J. Ritchie, research fellow ... the study. "Early remediation of reading problems might aid ...
Breaking Biology News(10 mins):Western Indian Ocean communities play vital role in conservation 2Singapore team develops Asia's first genetic test that can prevent corneal blindness 2Singapore team develops Asia's first genetic test that can prevent corneal blindness 3Stronger early reading skills predict higher intelligence later 2
... may plead, cajole or entice their children to try new foods, ... University of North Carolina at Chapel Hill reveals that the reason ... on their plate and more to do with their genes. ... at UNC,s Gillings School of Global Public Health, adds to the ...
... scientists led by Dr Kate Sanders from the University of ... Museum, has uncovered how some sea snakes have developed ,shrunken ... Their research is published today in the journal ... "all the better to eat you with" - would ...
... DNA sequence data is growing exponentially", says Miami University ... the genes that we identify, we have no idea ... a foreign language, waiting to be deciphered." Understanding the ... at the forefront of molecular biology. Many groups develop ...
Cached Biology News:Genes may be reason some kids are picky about food 2Scientists discover reasons behind snakes' 'shrinking heads' 2Genomic data are growing, but what do we really know? 2
(Date:7/24/2014)... 2014 WIRB-Copernicus Group ® ("WCG")™, ... review services for clinical research, announced today that ... of Richmond, VA -based Alliance ... biosecurity consulting firm in the United ... division – WCG Biosafety™ – will be able ...
(Date:7/24/2014)... Canada (PRWEB) July 24, 2014 The ... Optimizing Dose Escalation in First in Human Studies” will ... make better go/no-go decisions. , With increasing R&D costs ... pharmaceutical companies need to maximize the knowledge collected in ... decisions and improve success in late stage development. , ...
(Date:7/24/2014)... 24, 2014  Spherix Incorporated (SPEX) -- an intellectual ... of intellectual property, today announced that the Company will ... 30, 2014 on Monday, August 18, 2014 for shareholders. ... ET on Monday, August 18, 2014 to discuss the ... company,s CEO, Anthony Hayes . Following ...
(Date:7/24/2014)... 24, 2014 As part of the ... in the MENA region during 2014 with potential global ... provider agreement with DZS to manage our clinical trials ... Global VP of R&D and President of SBI pharmaceuticals ... operational practices with a focus on utilizing eClinical software ...
Breaking Biology Technology:WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2Spherix Schedules Shareholder Update Call 2SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2
... Ohio, July 8 Knowledge Enterprises, Inc.,and ... release of The,2007-2008 Orthopaedic Industry Annual Report, ... industry data. The nearly 200,page Annual Report ... to Joint Replacement, Fracture Repair, Arthroscopy/Soft,Tissue Repair, ...
... July 8 RADI Medical Systems today,announced ... guide,wire, PressureWire(R) Certus, which will begin shipments ... The latest generation of the PressureWire(R) ... which provides three key,advantages for physicians. The ...
... July 8 Telik, Inc.,(Nasdaq: TELK ), ... &,Medicinal Chemistry Letters describing a novel class of ... new treatment for diabetes.,These unique compounds are the ... to optimize the original lead structure identified through,the ...
Cached Biology Technology:Knowledge Enterprises, Inc. and The Institute for Orthopaedics(TM) Release The 2007-2008 Orthopaedic Industry Annual Report 2RADI Medical Systems Launches Next Generation PressureWire(R) Certus 2Telik Announces Publication of Diabetes Research in Bioorganic & Medicinal Chemistry Letters 2
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood CD8+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Biology Products: