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New insights into the development of the heart
Date:3/26/2013

chers modulated the experiments so that individual proteins of the signaling cascade were expressed at elevated or decreased levels, the cardiac cells showed subtle differences in "random walk" cell motility rates. This resulted in the development of hearts that were completely symmetrical or whose sides were laterally inverted.

Many of these malformations of the heart in zebrafish embryos are also known in humans. Often asymmetric disorders not only affect the heart but also other organs such as the spleen. It may be missing or two spleens may be present. Depending on the severity of the malformations, the problems of the affected individuals vary in seriousness. It is also possible that the processes identified by the researchers are also involved in the development of diseases in which cell migration plays a role.


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Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

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