Navigation Links
New insights into the 'borderline personality' brain
Date:1/17/2013

New work by University of Toronto Scarborough researchers gives the best description yet of the neural circuits that underlie a severe mental illness called Borderline Personality Disorder (BPD), and could lead to better treatments and diagnosis.

The work shows that brain regions that process negative emotions (for example, anger and sadness) are overactive in people with BPD, while brain regions that would normally help damp down negative emotions are underactive.

People with BPD tend to have unstable and turbulent emotions which can lead to chaotic relationships with others, and which put them at higher risk than average for suicide. A number of brain imaging studies have found differences in the function of brains of people with BPD, but some of the studies have been contradictory.

A team led by Anthony C. Ruocco, assistant professor in the Department of Psychology and program in neuroscience, analyzed data from 11 previously published studies and confirmed a number of important differences between people with BPD and those without.

On the one hand, a brain area called the insula which helps determine how intensely we experience negative emotions is hyperactive in people with BPD. On the other hand, regions in the frontal part of the brain which are thought to help us control our emotional reactions are underactive.

"It's not just that they have too much drive from their emotions," Ruocco says. "They seem to have less of the 'brakes' to try to curb those emotions and to help regulate their intensity."

The findings fit well with symptoms seen in people with BPD, Ruocco says. "The hallmark symptom that people describe is emotion dysregulation -- you're happy one moment, and the next moment you're feeling angry or sad or depressed. People with BPD can cycle through emotions, usually negative ones, quite rapidly."

More important is how the findings might be useful in diagnosis and treatment.
'/>"/>

Contact: Don Campbell
dcampbell@utsc.utoronto.ca
416-208-2938
University of Toronto Scarborough
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study offers new insights into the mechanics of muscle fatigue
2. New insights into how immune system fights atherosclerosis
3. Study offers insights into role of muscle weakness in Down syndrome
4. Basketball teams offer insights into building strategic networks
5. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
6. Insights into a new therapy for a rare form of cystic fibrosis
7. Notre Dame research could provide new insights into tuberculosis and other diseases
8. The ENCODE Project publishes new genomic insights in special issue of Genome Research
9. Piglets in mazes provide insights into human cognitive development
10. Feces fossils yield new insights into ancient diets and thrifty genes
11. Zebrafish provide insights into causes and treatment of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into the 'borderline personality' brain
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has ... Strategic Business Report" report to their offering. ... US$ Thousands. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... Latin America . Annual estimates and forecasts ...
(Date:3/17/2015)... 17, 2015 MedNet Solutions , ... clinical study management systems, is pleased to announce ... ARENA,s Outsourcing in Clinical Trials Southeast conference – ... an excellent forum for MedNet to showcase ... software-as-a-service (SaaS) eClinical technology platform. We ...
(Date:3/16/2015)... March 16, 2015 Between ... will present groundbreaking innovations in biometric identification at ... .      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ... innovation is well at the forefront: the company,s ... made in Germany . BiometricGate ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
... in Denmark revealed that increasing levels of non-fasting triglycerides ... in men and women. Higher cholesterol levels were associated ... this novel, 33-year study are now available online in ... Wiley-Blackwell on behalf of the American Neurological Association. ...
... decoded the DNA of the parasitic worm that causes ... pork or carnivorous wild game animals, such as bear ... Washington University School of Medicine in St. Louis and ... the parasite, Trichinella spiralis , which provide potential ...
... to different climates and diets as they split off from other ... for humans living today? A panel of scholars from ... Sunday February 20th at the AAAS meeting in Washington, DC, as ... at Work In Humans and Their Relatives." The speakers ...
Cached Biology News:Increasing triglyceride levels linked to greater stroke risk 2Trichinosis parasite gets DNA decoded 2Panelists to discuss evolution of human brain size, skin color and diet at AAAS meeting 2
(Date:4/17/2015)... April 17, 2015 LC Sciences ... technologies, announced today that it is seeking beta ... innovative multiplex PCR based targeted sequencing technology. The ... analysis, that enables accurate detection of rare variants. ... Omega-Primer™ technologies. The company will collaborate with beta ...
(Date:4/16/2015)... (PRWEB) April 17, 2015 Spirax ... system services, released their newly designed, state-of-the-art website ... customer facing website effectively promotes the Spirax Sarco ... All the information that a site visitor might ... services, company capabilities, industries serviced, the latest company ...
(Date:4/16/2015)... Mass. (PRWEB) April 16, 2015 ... smart data solutions driven by Semantic Web technology, ... of specialist information and services for the academic ... announced that its joint solution ‘Smart Data Lake ... a finalist for the 2015 Bio-IT ‘Best of ...
(Date:4/16/2015)... April 16, 2015 Capillus, LLC ... and physician network in Europe and Asia. The ... appointed Fernando Bermúdez, former Business Development Director of ... industry veteran, Mr. Bermúdez’s professional achievements include increasing ... Spain, while also penetrating the Portuguese marketplace with ...
Breaking Biology Technology:LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Spirax Sarco website has a new look 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2
... NOVEMBER 4, 2008, SAN DIEGO, Oct. 27 ... Kevin Gorman, President and Chief,Executive Officer of Neurocrine Biosciences ... in New York., The live presentation takes place ... /7:00 a.m. Pacific Time (PT). The presentation will,be simultaneously ...
... at 4:30 p.m. ET -, SOUTH SAN FRANCISCO, ... ) today reported financial results for the,quarter ended September ... million for the third quarter of,2008, 55% higher than ... was driven by revenue from Trofile(TM) for selecting HIV ...
... Lead Epidemiologist, RALEIGH, N.C., Oct. 27 ... the appointment of Dr.,Jerome Wilson as Senior Medical ... Dr. Wilson is responsible for providing consulting,services and ... provides extensive Phase IV Post-Marketing services to,pharmaceutical and ...
Cached Biology Technology:Neurocrine Biosciences to Present at the Oppenheimer 19th Annual Healthcare Conference 2Monogram Announces 2008 Third Quarter Financial Results 2Monogram Announces 2008 Third Quarter Financial Results 3Monogram Announces 2008 Third Quarter Financial Results 4Monogram Announces 2008 Third Quarter Financial Results 5Monogram Announces 2008 Third Quarter Financial Results 6Monogram Announces 2008 Third Quarter Financial Results 7Monogram Announces 2008 Third Quarter Financial Results 8Monogram Announces 2008 Third Quarter Financial Results 9Monogram Announces 2008 Third Quarter Financial Results 10Monogram Announces 2008 Third Quarter Financial Results 11Monogram Announces 2008 Third Quarter Financial Results 12Monogram Announces 2008 Third Quarter Financial Results 13Monogram Announces 2008 Third Quarter Financial Results 14Monogram Announces 2008 Third Quarter Financial Results 15Jerome Wilson Joins PRA International's Late Phase Service Group 2
... 'The DNAscope LM is a high quality microarray ... for optimal background rejection and spatial resolution. ... the only low cost microarray scanner that is ... sources. Main Features: Includes control ...
... Protein DetectorTM Microarray Dot Blot Kits ... accuracy and quantitation over a wide range ... formats ) detection. They are ideal ... profiling hundreds of samples for the presence ...
... Convenient, easy-to-use kits for arraying ... detection using common lab equipment. DiscoverLight ... analysis of your protein, cell lysate ... format. The kits include specially designed ...
Request Info...
Biology Products: