Navigation Links
New insights into the 'borderline personality' brain
Date:1/17/2013

New work by University of Toronto Scarborough researchers gives the best description yet of the neural circuits that underlie a severe mental illness called Borderline Personality Disorder (BPD), and could lead to better treatments and diagnosis.

The work shows that brain regions that process negative emotions (for example, anger and sadness) are overactive in people with BPD, while brain regions that would normally help damp down negative emotions are underactive.

People with BPD tend to have unstable and turbulent emotions which can lead to chaotic relationships with others, and which put them at higher risk than average for suicide. A number of brain imaging studies have found differences in the function of brains of people with BPD, but some of the studies have been contradictory.

A team led by Anthony C. Ruocco, assistant professor in the Department of Psychology and program in neuroscience, analyzed data from 11 previously published studies and confirmed a number of important differences between people with BPD and those without.

On the one hand, a brain area called the insula which helps determine how intensely we experience negative emotions is hyperactive in people with BPD. On the other hand, regions in the frontal part of the brain which are thought to help us control our emotional reactions are underactive.

"It's not just that they have too much drive from their emotions," Ruocco says. "They seem to have less of the 'brakes' to try to curb those emotions and to help regulate their intensity."

The findings fit well with symptoms seen in people with BPD, Ruocco says. "The hallmark symptom that people describe is emotion dysregulation -- you're happy one moment, and the next moment you're feeling angry or sad or depressed. People with BPD can cycle through emotions, usually negative ones, quite rapidly."

More important is how the findings might be useful in diagnosis and treatment.
'/>"/>

Contact: Don Campbell
dcampbell@utsc.utoronto.ca
416-208-2938
University of Toronto Scarborough
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study offers new insights into the mechanics of muscle fatigue
2. New insights into how immune system fights atherosclerosis
3. Study offers insights into role of muscle weakness in Down syndrome
4. Basketball teams offer insights into building strategic networks
5. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
6. Insights into a new therapy for a rare form of cystic fibrosis
7. Notre Dame research could provide new insights into tuberculosis and other diseases
8. The ENCODE Project publishes new genomic insights in special issue of Genome Research
9. Piglets in mazes provide insights into human cognitive development
10. Feces fossils yield new insights into ancient diets and thrifty genes
11. Zebrafish provide insights into causes and treatment of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into the 'borderline personality' brain
(Date:8/21/2014)... implications for life in other extreme environments, both on ... Associate Professor of Biological Sciences Brent Christner and fellow ... this week published a paper confirming that the waters ... (2600 feet) beneath the surface of the West Antarctic ... than 400 subglacial lakes and numerous rivers and streams ...
(Date:8/21/2014)... to Wednesday, Oct. 18-22, 2014 , WHERE: ... Drive, San Diego, CA 92101 , WHAT: ... presentations of the latest research in human genetics. ... featuring high-scoring abstracts on rare genetic variants in ... and treatment for sun sensitivity (Saturday, Oct. 18, ...
(Date:8/21/2014)... researchers at Louisiana Tech University has developed ... 3D printers and materials to fabricate custom ... chemotherapeutic compounds for targeted drug delivery. , ... research faculty from Louisiana Tech,s biomedical engineering ... filament extruders that can make medical-quality 3D ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3
... Washington, D.C. -- Disease statistics buried within patient ... and organized to depict geographic patterns, allowing the discovery ... Penn State geographer. "The use of interactive maps ... to greater insight into complex events like the spread ...
... region has a hot, wet climate and a lot of ... a really good chance the region will also contain numerous ... study examining the geography of human disease, led by Dr. ... team of biologists and social scientists, shows that that one ...
... world-wide project "MAGICPAH", coordinated by the Braunschweiger Helmholtz-Zentrums ... Braunschweig- HZI), is examining how bacterial communities are ... aromatic hydrocarbons. "MAGICPAH" is a collaboration of thirteen ... enterprises have initiated the project today at the ...
Cached Biology News:Visualization of geographic patterns may predict spread of disease 2Study pins factors behind geography of human disease 2Study pins factors behind geography of human disease 3Improving the degradation of toxic hydrocarbons 2
(Date:8/20/2014)... lessons often have it that American Indians largely were ... pox, influenza and tuberculosis brought to the New World ... about 20 million people lived in the Americas shortly ... were killed by European diseases., But new research led ... and Johannes Krause of the University of Tubingen in ...
(Date:8/20/2014)... High performance computing (HPC) will be ... climate and Earth system model to address the ... Eight national laboratories, including Lawrence Livermore , ... Atmospheric Research, four academic institutions and one private-sector ... laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los Alamos, ...
(Date:8/20/2014)... The 6th Annual Arrowhead Personalized and ... 29-30 in San Francisco, CA. This year’s conference brings ... and clinicians focused on addressing and solving the significant ... twelve years since the sequencing of the human genome, ... pharmacogenetic information in the label and molecular diagnostics have ...
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
Breaking Biology Technology:Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2
... RATON, Fla., Feb. 17, 2011 Sensus ... participation in the 9th Annual South Beach ... 17-21, 2011.  The South Beach Symposium™ is a comprehensive ... and practice management. Sensus Healthcare is featuring superficial radiotherapy ...
... of Santiago de Compostela (USC) have analysed levels of radon, ... The results show that 34% of these schools exceed the ... inhalation of radon is associated with lung cancer. "Out ... had radon levels in excess of 400 Bequerels/m3 in some ...
... a significant component of the defense system of many ... armies and terrorist organizations, and constitute a threat to ... solutions against them have limited efficiency. A multidisciplinary ... succeeded in developing an enzyme that breaks down such ...
Cached Biology Technology:Sensus Healthcare Announces Its Exhibitor Attendance at the 9th Annual South Beach Symposium™ 234 percent of Galician secondary schools exceed maximum recommended radon levels 2Weizmann Institute scientists used accelerated evolution to develop enzymes that provide protection against nerve gas 2Weizmann Institute scientists used accelerated evolution to develop enzymes that provide protection against nerve gas 3Weizmann Institute scientists used accelerated evolution to develop enzymes that provide protection against nerve gas 4
ANTI FLAG EP CL VEC...
Cross reactivity to St. Louis encephalitis (MSI-7) is determined by ELISA....
EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
RABBIT ANTI HUMAN ATR (aa2122-2380) Immunogen: Human ATR peptide, amino acids 2122-2380...
Biology Products: