Navigation Links
New insight into double-protected dance of cell division
Date:3/5/2013

AMHERST, Mass. Biochemists at the University of Massachusetts Amherst including assistant professor Peter Chien recently gained new insight into how protein synthesis and degradation help to regulate the delicate ballet of cell division. In particular, they reveal how two proteins shelter each other in "mutually assured cleanup" to insure that division goes smoothly and safely.

Cells must routinely dispose of leftover proteins with the aid of proteases that cut up and recycle used proteins. The problem for biochemists is that the same protein molecule can be toxic garbage at one time, but essential for function at another time such as during the cell cycle, that is, events that unfold to achieve replication of chromosomes and division of the cell.

As Chien explains, "We know that a process that has to happen as reliably and stably as cell division also has to be flexible enough to allow the organism to grow and respond to its ever-changing environment. We're interested in uncovering all the steps and back-up safeguards that cells use to robustly protect replication while at the same time allowing other functions to proceed." Results appear in the early online edition of Molecular Microbiology.

To do this work, Amber Cantin in Chien's lab, closely collaborated with Michael Laub and colleagues at MIT to look in a bacteria, Caulobacter, where they had previously figured out how cells distinguish waste proteins from useful molecules. They focused on a protein called CtrA that sits on DNA like a cap, controlling replication until conditions are right for division to occur.

Destruction of CtrA allows cells to start replicating their chromosome. Cantin used biochemical experiments with highly purified proteins to show that CtrA was only degraded when it was bound to DNA and that another protein, SciP, could help make CtrA bind better to DNA, making CtrA more resistant to proteolysis.

Surprisingly, thi
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Misplaced molecules: New insights into the causes of dementia
2. Study provides insights into plant evolution
3. A microbial biorefinery provides new insight into how bacteria regulate genes
4. Life experiences put their stamp on the next generation: New insights from epigenetics
5. Random Forests Tree Ensembles: Salford Systems Exclusive Insight
6. Discovery of sexual mating in Candida albicans could provide insights into infections
7. UCSB research provides insight into mechanics of arthritis
8. New insights into the borderline personality brain
9. Study offers new insights into the mechanics of muscle fatigue
10. UNC research uncovers new insight into cell development and cancer
11. Gout study offers genetic insight into disease of kings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insight into double-protected dance of cell division
(Date:5/21/2015)... 21, 2015 According to ... Solutions (Hardware, Software, Services), by Applications (Surveillance (Airborne, ... by End-Users (Military & Defense & Commercial) - ... Imaging Market is expected to grow from $7252.0 ... at a Compound Annual Growth Rate (CAGR) of ...
(Date:5/20/2015)... , May 20, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the addition ... the Global Iris Recognition Market"  report ... , ,This research service analyses trends ... the government and commercial sectors, globally. ...
(Date:5/19/2015)... Fingerprint Cards (FPC) has received an order for ... from one if its module partners. Deliveries are planned to ... the sensors will be used by smartphone manufacturers in ... amount to 740 MSEK to date. In addition to previously ... number of smaller orders not separately communicated amounting to more ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... 15, 2013 Originally, the label "borderline personality disorder" ... a middle ground between patients with neurotic and psychotic ... focused on the heightened emotional reactivity observed in patients ... with which they also meet diagnostic criteria for posttraumatic ...
... Fisheries managers should sharpen their ability to spot environmental ... assuming that having a certain abundance of fish assures ... the potential harvest of fish is only closely linked ... assessed in a University of Washington-led study, according to ...
... climatologists up to the year 2080 will benefit most mammals ... today if they are able to reach their new climatic ... University in a recently published article in the journal ... and Christer Nilsson of the Department of Ecology and Environmental ...
Cached Biology News:Borderline personality disorder: The "perfect storm" of emotion dysregulation 2Potential harvest of most fish stocks largely unrelated to abundance 2Potential harvest of most fish stocks largely unrelated to abundance 3
(Date:5/21/2015)... Seventh Wave Laboratories, a consulting-based contract research ... products and medical devices, announced the purchase of 19 ... sq. ft. building more than three times the size ... renovations will begin immediately and the gradual transition of ... September. , “We are excited about this growth,” ...
(Date:5/21/2015)... May 21, 2015  The EveryLife Foundation for ... (R-UT) and Amy Klobuchar (D-MN) today ... Cures & Treatments, or OPEN ACT. ... advocacy organizations, this bipartisan legislation promises to rapidly ... to rare disease patients by incentivizing drug makers ...
(Date:5/21/2015)... 2015 As part of its philanthropic ... Sun Health Foundation funded a $3.25 million project to ... with the most up-to-date features and technology. , The ... pharmacy's 45 staff members will begin moving from the ... the coming days. , The current pharmacy has ...
(Date:5/20/2015)... FRANCISCO, Calif. , May 20, 2015 /PRNewswire/ ... ) today presented preliminary data demonstrating the ability ... idiopathic pulmonary fibrosis (IPF) from other interstitial lung ... findings suggest the classifier,s potential to help thousands ... to resolve ambiguity in IPF diagnosis – a ...
Breaking Biology Technology:Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 2Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 3Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5
... - Throughout the opening sessions of the 2006 Fuel ... Milwaukee, speakers criticized the State Senate for rejecting ... Joint Committee on Finance has given them one more ... no action on an ethanol incentive proposed by Governor ...
... SC Johnson has issued a cease-and-desist letter for ... of SC Johnson products for spam purposes. , ,FreeShowerCleaner.com, ... a free Scrubbing Bubbles Automatic Shower cleaner in exchange ... a global provider of household cleaning and storage products, ...
... - A collaborative project between the University of ... in Haifa has shown that thousands of sleeping ... , , Superlink-Online , a program first developed at ... the genomes of affected families, has since grown to ...
Cached Biology Technology:Joint Finance blocks Doyle ethanol measure 2Joint Finance blocks Doyle ethanol measure 3UW links with Israeli school to locate genes 2UW links with Israeli school to locate genes 3
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
... Fluoroskan Ascent is a dedicated ... for all kinds of assays ... and for clinical applications. Cell ... are all important application areas. ...
... latest SpeedVac Concentrator, the SPD series takes ... new modern twist., The SPD121P SpeedVac comes ... for optimizing runs; preventing samples from freezing; ... at the end-users preset level., Standard features ...
... personal desktop unit ideal for use in laboratories ... Rotation speed set at 12 rpm , ... , Bottle capacity of four 35 x 150mm ... ,plastic bottles , Consistent, repeatable results achieved ...
Biology Products: