Navigation Links
New immune defense enzyme discovered
Date:4/3/2012

This release is available in German.

Neutrophil granulocytes comprise important defences for the immune system. When pathogenic bacteria penetrate the body, they are the first on the scene to mobilise other immune cells via signal molecules, thereby containing the risk. To this end, they release serine proteases enzymes that cut up other proteins to activate signal molecules. Scientists at the Max Planck Institute of Neurobiology in Martinsried have now discovered a new serine protease: neutrophil serine protease 4, or NSP4. This enzyme could provide a new target for the treatment of diseases that involve an overactive immune system, such as rheumatoid arthritis.

The functioning of the immune system is based on the complex interplay of the most diverse cells and mediators. For example, neutrophil granulocytes (a group of specialized white blood cells) react to bacteria by releasing substances called serine proteases. These enzymes are able to activate signal molecules, such as the chemokines, by cleaving them at a specific position on the molecule. The active signal molecules then guide other immune cells to the focus of inflammation in order to destroy the pathogens.

A research team led by Dieter Jenne at the Max Planck Institute of Neurobiology in Martinsried has come across a previously unknown protease in humans: neutrophil serine protease 4, or NSP4. "The special thing about this enzyme is that it cuts proteins that have the amino acid arginine at a particular point", says Dieter Jenne, research group leader at the Martinsried-based Institute. "This is where NSP4 differs from the other three known neutrophil serine proteases, which are similar in molecular structure, but have a different recognition motif." The scientists may be able to harness this difference to develop an active substance that specifically inhibits NSP4, there
'/>"/>

Contact: Dr. Dieter Jenne
djenne@neuro.mpg.de
49-898-578-3588
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Key to immune system disease could lie inside the cheek
2. Immune system implicated in prematurity complication
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. UCI-led study uncovers how Salmonella avoids the bodys immune response
5. U of Alberta researcher steps closer to understand autoimmune diseases
6. Depression could be evolutionary byproduct of immune system
7. Secrets of immune response illuminated in new study
8. Human immune cells react sensitively to stress
9. Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
10. Aiding cancer therapy by mathematically modeling tumor-immune interactions
11. UCSF team uncovers how immune cells move against invaders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New immune defense enzyme discovered
(Date:2/5/2015)... 28, 2015 New Market Research ... Segment Forecasts To 2020 has Been Added to GrandViewReseach.com ... is expected to reach USD 5.10 billion by 2020, ... Inc. IR cameras help identify the site of tissue ... witness surging demand in medical imaging applications. They have ...
(Date:1/22/2015)... Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the addition ... report to their offering. , The primary ... is who she/he is claiming to be, and for this ... physical characteristics, such as fingerprint, hand or palm print, iris, ...
(Date:1/22/2015)... MADISON, Wis. , Jan. 15, 2015  BellBrook ... for drug discovery, announced the launch of a ... of the company,s Transcreener UDP Assay, a high ... enzymes. The new assay will allow for sensitive ...
Breaking Biology News(10 mins):IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... Novartis announced today that scientists at the Novartis ... from the Genomics Institute of the Novartis Research Foundation ... The Scripps Research Institute have discovered a novel compound ... drug resistant malaria. Major support for the project was ...
... California Institute of Technology (Caltech) have devised a new ... visualize the structure of molecules. The technique, which was ... water coats surfaces at room temperature, can also be ... molecules, including antibodies and other biomolecules. A paper ...
... of the first implantable artificial kidney, in a development ... The device, which would include thousands of microscopic ... metabolic and water-balancing roles of a real kidney, is ... and physicians nationwide, led by Shuvo Roy, PhD, in ...
Cached Biology News:Novartis and collaborators discover novel antimalarial drug candidate 2Novartis and collaborators discover novel antimalarial drug candidate 3Caltech chemists develop simple technique to visualize atomic-scale structures 2Caltech chemists develop simple technique to visualize atomic-scale structures 3UCSF unveils model for implantable artificial kidney to replace dialysis 2UCSF unveils model for implantable artificial kidney to replace dialysis 3
(Date:3/4/2015)... March 4, 2015 ... Paris en décembre 2011, l,étude ...   », qui compare   l es ...   sorafénib dans le carcinome hépatocellulaire avancé, a ... du foie avancé   ; les résultats sont ...
(Date:3/3/2015)... 03, 2015 Experts and industry insiders ... one event: the Alltech REBELation exploring innovation, inspiration and ... Now in its 31st year, Alltech’s annual international conference ... and the opportunity to join the REBELation at an ... 11:59 p.m. EST, at which point the standard early ...
(Date:3/3/2015)... -- Adaptive Biotechnologies announced today that Chad Cohen ... Director as Chair of the Audit Committee. ... all finance, treasury and accounting functions. Since joining Zillow ... and accounting functions, and led the finance organization through ... was named Puget Sound Business Journal,s CFO of the ...
(Date:3/3/2015)... Calif. (PRWEB) March 03, 2015 The ... management excellence were honored by the Global Supply ... event which took place on Wednesday, February 25th, 2015, ... The GSCRC was formed to bring together supply chain ... leaders to advance the professional discipline through opportunities to ...
Breaking Biology Technology:Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 2Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 3Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 4Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 5Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 6World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2Global Supply Chain Resiliency Council Names Award Winners 2Global Supply Chain Resiliency Council Names Award Winners 3Global Supply Chain Resiliency Council Names Award Winners 4
... Aug. 16, 2011 Quanterix Corporation, a company ... based on its revolutionary Si ngle ... STRATEC Biomedical AG (Frankfurt: SBS; Prime Standard, TecDAX), ... of automated analyzer systems, today announced an agreement ...
... The Society of Interventional Radiology Foundation launched a ... the future of the specialty with its announcement ... student conducting preclinical research in interventional radiology during ... prestigious Medical Research Fellows Program. (Logo: ...
... 2011 PharmAthene, Inc. (NYSE Amex: PIP ... and chemical threats, announced today that the Company has ... of Defense (DoD) Broad Agency Announcement for studies directed ... the bioproduction of its nerve agent medical countermeasure program. ...
Cached Biology Technology:Quanterix and STRATEC Announce Strategic Partnership 2Quanterix and STRATEC Announce Strategic Partnership 3Society of Interventional Radiology Foundation Funds Howard Hughes Medical Institute Award 2Society of Interventional Radiology Foundation Funds Howard Hughes Medical Institute Award 3Department of Defense Awards $5.7 Million Contract to PharmAthene for Nerve Agent Medical Countermeasure Program 2Department of Defense Awards $5.7 Million Contract to PharmAthene for Nerve Agent Medical Countermeasure Program 3Department of Defense Awards $5.7 Million Contract to PharmAthene for Nerve Agent Medical Countermeasure Program 4