Navigation Links
New hope for treating Alzheimer's Disease: A role for the FKBP52 protein
Date:3/20/2012

New research in humans published today reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.

A study published online today in the Journal of Alzheimer's Disease (1), for the first time demonstrates that the FKBP52 protein, discovered by Prof. Etienne BAULIEU twenty years ago, may prevent hyperphosphorylation of Tau protein, which has been shown to characterise a number of cerebral neurodegenerative diseases, including Alzheimer's Disease (AD).

This work has been carried out by Professor Etienne Baulieu and his research team at Inserm (National Institute for medical research in France) with the support of philanthropists who help the Institut Baulieu, based in France.

Limited research exists on Tau and its role in the development of AD, but it is known that many neurodegenerative diseases are characterised by the deposition of pathological hyperphosphorylated forms of Tau protein, into structures known as 'Tau tangles'. The mechanism of Tau toxicity is unclear and there are currently no drug treatments targeting Tau, nor any biomarkers that predict the risk of a future "Tauopathy". Professor Baulieu decided to focus on Tau abnormalities and was the first to discover in 2010, an interaction between Tau, and the FKBP52 protein (2).

The new research takes his previous research to the next level. It demonstrates a direct correlation between high levels of hyperphosphorylated Tau protein and reduced levels of FKBP52, in brain cells from patients who have died following Alzheimer's Disease, compared with normal brain cells. This suggests that FKBP52 could control the aberrant production of pathogenic Tau. When FKBP52 is reduced in the nerve cells of AD patients, pathogenic Tau is free to accumulate and contribute to the degeneration of brain cell
'/>"/>

Contact: Kristin Shine
KShine@brunswickgroup.com
44-207-404-5959
IOS Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. New approach to treating cystic fibrosis lung infection shows promise
2. Commercial aquatic plants offer cost-effective method for treating wastewater
3. Pitt research identifies new target in brain for treating schizophrenia
4. UC Davis discovery offers hope for treating kidney cancer
5. World breakthrough in treating premature babies
6. Studies point to novel target for treating arrhythmias
7. Antibody key to treating variant CJD, scientists find
8. New medications show promise in treating drug-resistant prostate cancer
9. NC State researchers find soy may aid in treating canine cancers
10. New drug shows promise in treating drug-resistant prostate cancer
11. Cold and brown fat raise the prospect of a new method of treating obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... German . ... to behave socially? This is one of the central ... studies assumed that it is almost impossible to control ... Planck Institute for Evolutionary Biology have now demonstrated that ... cooperative behaviour of others. However, the possibilities available to ...
(Date:10/30/2014)... 29, 2014  Securus Technologies, a leading ... solutions for public safety, investigation, corrections and ... exciting enhancements to its THREADS™ product, which ... actionable intelligence and focused leads for investigators. ... technological innovation through identifying and delivering solutions ...
(Date:10/29/2014)... open for the Society of Interventional Radiology,s ... is the one place where interventional radiologists, ... care professionals can come together to find ... being presented, discussed and tested. , ... image-guided medicine, SIR 2015 will feature essential ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... Tenn. Consider the case of the three-spine stickleback. ... fresh water might appear to be the same, yet ... collection of very specialized individuals. Understanding the ... the goal of a group of scientists meeting at ...
... Stephania Cormier, PhD, Associate Professor of Pharmacology ... shown for the first time that early exposure ... ultrafine particulate matter) affects long-term lung function. She ... 11th International Congress on Combustion By-Products and Their ...
... research that allows farmers to harvest rice earlier, giving them ... needed food and ease hunger during monga -- the hunger ... northwest Bangladesh from September to November after the previous season,s ... rice in December. According to the Bangladesh Bureau ...
Cached Biology News:The value of variation: Ecologists consider the causes and consequences 2LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease 2Early rice harvests ease annual famine in Bangladesh 2
(Date:10/31/2014)... Edwardsville, Ill. (PRWEB) October 31, 2014 ... Edwardsville’s Department of Historical Studies within the College of ... at SIUE to record the history of alcohol-based fuels ... politicians, and many others have been working to build ... an important but overlooked aspect of the state's agricultural ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) Market ... Sweetened, Unsweetened), Channel (Supermarket, Health Store, Pharmacy, Convenience ... to 2018," defines and segments the dairy alternative ... revenue and volume for plant-based dairy alternative beverages. ... $14 Billion by 2018 with the Asia-Pacific region ...
(Date:10/31/2014)... New York, NY (PRWEB) October 31, 2014 ... sectors such as healthcare, construction, finance and consumer ... applications. For this reason, industry research firm IBISWorld ... Software industry to its growing industry report collection. ... that develop software for biometric technologies such as ...
(Date:10/30/2014)... The report “Fragrance Ingredients Market by Type (Essential ... and Soaps & Detergents) & by Geography - Global ... the Fragrance Ingredients Market with analyses and projection of ... market has been segmented on the basis of major ... and Rest of the World (ROW); and their value ...
Breaking Biology Technology:SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5
... Expedites Reporting Process, WALL, N.J., Oct. 24 ... leader in wireless public safety,solutions and finger based ... from the Littleton, Colorado Police Department,to implement the ... is a module of BIO-key,s Mobile Office(TM) solution. ...
... SAN FRANCISCO, Oct. 24 Cell Therapeutics,Inc. ... data presented at,the 19th annual AACR-NCI-EORTC Symposium ... kill tumors refractory to currently,marketed platinum agents ... human clinical trials in late 2008. ...
... (Nasdaq: KERX ) will hold a conference call ... discuss the Third Quarter 2007 financial results.,Michael S. Weiss, ... the call. Keryx will announce its financial results for ... to the call. In order to participate in ...
Cached Biology Technology:BIO-key(R) Awarded Contract to Deploy Incident Reporting System for Littleton, CO Police Department 2First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 2First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 3Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Third Quarter 2007 Financial Results on Thursday, October 25, at 8:30 A.M. EDT 2
... to detect the appearance of AcNPV gp64 ... as early as 8-24 hours post-infection. This ... Kit, which allows determination of baculovirus titers ... FastPlax Antibody can also be used to ...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
MAb to Transferrin Dry Ice: No Preservative: NaN3 Availability When Not in Inventory: 14-21 Business Days...
Biology Products: