Navigation Links
New genomics study shows ancestry could help solve disease riddles
Date:10/25/2012

LA JOLLA, CA October 25, 2012 Explosive advancement in human genome sequencing opens new possibilities for identifying the genetic roots of certain diseases and finding cures. However, so many variations among individual genomes exist that identifying mutations responsible for a specific disease has in many cases proven an insurmountable challenge. But now a new study by scientists at The Scripps Research Institute (TSRI), Scripps Health, and Scripps Translational Science Institute (STSI) reveals that by comparing the genomes of diseased patients with the genomes of people with sufficiently similar ancestries could dramatically simplify searches for harmful mutations, opening new treatment possibilities.

The work, reported recently in the journal Frontiers in Genetics: Applied Genetic Epidemiology, should speed the search for the causes of many diseases and provide critical guidance to the genomics field for maximizing the potential benefits of growing genome databases.

Much work is already under way to sequence the DNA of people suffering from diseases with unknown causes, called idiopathic conditions, to find the roots of their problems. Unlike more complex conditions such as diabetes, in some cases a limited number of genetic defects, or even a single mutation, can cause an idiopathic disease. Identifying those critical mutations can lead to effective treatments for previously mysterious problems.

Complicated Searches

While there have been some successes, in many other instances the genetic basis of an idiopathic disease remains elusive. Among other groups, The National Human Genome Research Institute runs searches for idiopathic disease sufferers and is able to find offending gene sequences only about 30 percent of the time. "One explanation for that other 70 percent might be that the diseases are enormously complex," said the new study's senior author Nicholas Schork, a professor at TSRI, director of r
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Physiological Genomics journal announces a major restructuring
2. 2 pioneering plant genomics efforts given a funding boost by National Science Foundation
3. ShanghaiBio Corporation Partners with Ingenuity Systems to Address Challenges in Analysis and Interpretation of Genomics Data
4. Elsevier launches new open access journal: Applied and Translational Genomics
5. The genomics symposium to boost the further development of cancer research
6. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
7. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
8. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
9. SDSCs big data expertise aiding genomics research
10. A new technique to study how myeloids become white blood cells
11. University of Toronto study demonstrates impact of adversity on early life development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New genomics study shows ancestry could help solve disease riddles
(Date:7/31/2014)... Census Bureau, Latinos are the largest minority group in ... Approximately one-third of Latinos are obese and are 1.2 ... Whites. , NYU College of Nursing student researcher ... identify the factors that contribute to this problem by ... on food patterns in Latina women recently published in ...
(Date:7/31/2014)... beneath many of the roughly 156,000 gas stations ... corrosion in parts of underground gas storage tankscorrosion ... of groundwater, a source of drinking water. In ... reported many rapidly corroding gas storage tank components ... associated with use of gasoline-ethanol blends and the ...
(Date:7/31/2014)... experimental vaccine protected 100 percent of animal models against ... , which causes an intestinal disease that kills approximately ... print in Infection and Immunity . , ... non-human primates against the purified toxins produced by ... spore infection, a laboratory model that mimics the human ...
Breaking Biology News(10 mins):NYU research looks to combat US Latina immigrant obesity 2NIST corrosion lab tests suggest need for underground gas tank retrofits 2C. difficile vaccine proves safe, 100 percent effective in animal models 2
... team of neuroengineers based at Brown University has developed ... of relaying real-time broadband signals from up to 100 ... novel low-power device, described in the Journal of ... models for more than year, a first in the ...
... long-term consequences of childhood obesity are well documented, some ... more time to the 3 Rs in educationreading, writing, ... leaving out an important fourth Raerobicscould actually be counterproductive ... for publication in The Journal of Pediatrics ...
... at Wake Forest Baptist Medical Center and colleagues have ... bone marrow that have the natural ability to migrate ... potential to restore healthy tissue in patients with inflammatory ... have IBD, which is characterized by frequent diarrhea and ...
Cached Biology News:Brown unveils novel wireless brain sensor 2Brown unveils novel wireless brain sensor 3Brown unveils novel wireless brain sensor 4Reading, writing, arithmetic, and aerobics -- Evaluating the new 'R' in academic performance 2Research supports promise of cell therapy for bowel disease 2
(Date:7/31/2014)... “2014 Deep Research Report ... is a professional and in-depth research report ... Polyurethane Resin basic information, including its definition, ... industry overview. This research covers the international ... well as global industry analysis covering macroeconomic ...
(Date:7/31/2014)... even the entire body to visualize long-range connections between ... a long-time dream of biologists. A study published by ... Cell has now made that dream a ... and human tissue biopsies transparent, while keeping the cellular ... way for a better understanding of brain-body interactions, more ...
(Date:7/31/2014)... , July 31, 2014 Rogne Bioscience, a ... Bay Area , has acquired a licence to ... commercialisation company. The potent anti-inflammatory activity of the peptides ... the University of Oxford,s Sir William Dunn School ... has raised over $1.5 million in seed financing, is ...
(Date:7/31/2014)... San Francisco, California (PRWEB) July 31, 2014 ... expert systems that inform therapeutic decision-making in oncology, today ... on August 14, 2014 to discuss the Company's financial ... to provide an update about the business in the ... live audio call beginning on Thursday, August 14, 2014, ...
Breaking Biology Technology:Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4See-through organs and bodies will accelerate biomedical discoveries 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
... 2011 SimPL, the Simple Platform for Learning, is ... regulatory training , eLearning and classroom ... Healthcare administrators and educators spend a great deal of ... for those organizations that want a system that is ...
... Wis., Aug. 11, 2011 Cellular Dynamics International (CDI) ... Grant Program. This grant program will advance researchers, understanding ... types derived from them, and the role and applications ... research, drug discovery and development.   "The ...
... of experts, led by a Case Western Reserve ... bring unrivaled qualities found in one- and two-dimensional ... is to produce new materials for a host ... cells and hydrogen storage devices to lightweight thermal ...
Cached Biology Technology:The SimPL Learning Management System Supports Compliance in Healthcare Facilities 2Cellular Dynamics Launches Innovative Research Grant Program 2Teaming up to build 3-D nanomaterials 2Teaming up to build 3-D nanomaterials 3
... for the use of small interfering RNA ... the RNA interference (RNAi) pathway have generated ... biology fields. siRNA for experimental use can ... enzymatically, and then transfected into the target ...
... potential applications for the use of small ... expression via the RNA interference,(RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... enzymatically, and then transfected into the target ...
... The HybArray 12™ is an automated hybridization ... The system automates both the hybridization and ... glass slides. A single instrument can process ... in pairs and has multi-protocol software, enabling ...
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
Biology Products: