Navigation Links
New genomics study shows ancestry could help solve disease riddles
Date:10/25/2012

LA JOLLA, CA October 25, 2012 Explosive advancement in human genome sequencing opens new possibilities for identifying the genetic roots of certain diseases and finding cures. However, so many variations among individual genomes exist that identifying mutations responsible for a specific disease has in many cases proven an insurmountable challenge. But now a new study by scientists at The Scripps Research Institute (TSRI), Scripps Health, and Scripps Translational Science Institute (STSI) reveals that by comparing the genomes of diseased patients with the genomes of people with sufficiently similar ancestries could dramatically simplify searches for harmful mutations, opening new treatment possibilities.

The work, reported recently in the journal Frontiers in Genetics: Applied Genetic Epidemiology, should speed the search for the causes of many diseases and provide critical guidance to the genomics field for maximizing the potential benefits of growing genome databases.

Much work is already under way to sequence the DNA of people suffering from diseases with unknown causes, called idiopathic conditions, to find the roots of their problems. Unlike more complex conditions such as diabetes, in some cases a limited number of genetic defects, or even a single mutation, can cause an idiopathic disease. Identifying those critical mutations can lead to effective treatments for previously mysterious problems.

Complicated Searches

While there have been some successes, in many other instances the genetic basis of an idiopathic disease remains elusive. Among other groups, The National Human Genome Research Institute runs searches for idiopathic disease sufferers and is able to find offending gene sequences only about 30 percent of the time. "One explanation for that other 70 percent might be that the diseases are enormously complex," said the new study's senior author Nicholas Schork, a professor at TSRI, director of r
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Physiological Genomics journal announces a major restructuring
2. 2 pioneering plant genomics efforts given a funding boost by National Science Foundation
3. ShanghaiBio Corporation Partners with Ingenuity Systems to Address Challenges in Analysis and Interpretation of Genomics Data
4. Elsevier launches new open access journal: Applied and Translational Genomics
5. The genomics symposium to boost the further development of cancer research
6. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
7. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
8. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
9. SDSCs big data expertise aiding genomics research
10. A new technique to study how myeloids become white blood cells
11. University of Toronto study demonstrates impact of adversity on early life development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New genomics study shows ancestry could help solve disease riddles
(Date:4/22/2014)... Fla. (April 21, 2014) -- There are all sorts ... feathers and spread their colorful tails; satin bowbirds build ... blue and shiny objects; and European bitterling males show ... has evolved a unique method to communicate with others. ... "Signaling can have profound fitness implications for ...
(Date:4/22/2014)... RIVERSIDE, Calif. Inspired by the fist-like club ... by University of California, Riverside, in collaboration with University ... design structure for composite materials that is more impact ... , "The more we study the club of this ... improve so many things we use every day," said ...
(Date:4/22/2014)... of nanotechnology researchers at the University of Kentucky has ... arrays using RNA. , The research, led by ... in Nanobiotechnology at the UK College of Pharmacy and ... "RNA as a Boiling-Resistant Anionic Polymer Material To Build ... Emil F. Khisamutdinov and Daniel L. Jasinski. , The ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3Mantis shrimp stronger than airplanes 2Mantis shrimp stronger than airplanes 3RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2
... For the first time, researchers have confirmed an association ... and abnormalities on brain MRI, according to a new ... The new study raises the possibility that a toxic ... body long after administration. Brain MRI exams ...
... Peterhans, a Roosevelt University professor and adjunct curator at ... mammals in Africa, has announced the discovery of four ... of the Democratic Republic of Congo. , The mammals ... led by the Wildlife Conservation Society (WCS) and in ...
... of millions of Americans, there,s no such thing as the ... hear a constant ringing, buzzing, hissing, humming or other noise ... be debilitating and life-altering. Now, University of Michigan ... what is going on inside their unquiet brains. The ...
Cached Biology News:Contrast agent linked with brain abnormalities on MRI 2Chicago scientist involved in discovery of 4 new mammal species in Democratic Republic of Congo 2U-M tinnitus discovery opens door to possible new treatment avenues 2U-M tinnitus discovery opens door to possible new treatment avenues 3
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... 2014 Two champions of science, technology, ... of an annual competition for middle and high school ... innovative STEM study. The competition presents students with real-world ... Engineering Aptitude, Mathematics, and Sciences is a program ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... 2012 AtheroNova Inc. (OTCBB: AHRO), a biotech company ... regress atherosclerotic plaque, today announced that it has released ... company, no revenues were recognized in the twelve months ... for 2011 compared to $2,679,435 in 2010.  Net income ...
... 2012 Profil ® Institute for Clinical Research, Inc., ... and obesity, announced today its continued focus on contributing to ... on new therapies in diabetes in nine scientific journals last ... has authored two textbooks on drug therapy for type 2 ...
... Scientists are one step closer to making more complex microscopic ... "re-wire" DNA in yeast, according to research published today in ... Imperial College London, have demonstrated a way of creating a ... DNA and behave like wires in electronic circuitry. The scientists ...
Cached Biology Technology:AtheroNova Releases 2011 Financial Results 2AtheroNova Releases 2011 Financial Results 3Profil Institute Continues to Publish New Findings in Metabolic Research 2Scientists develop tools to make more complex biological machines from yeast 2
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Biology Products: