Navigation Links
New genomics study shows ancestry could help solve disease riddles
Date:10/25/2012

LA JOLLA, CA October 25, 2012 Explosive advancement in human genome sequencing opens new possibilities for identifying the genetic roots of certain diseases and finding cures. However, so many variations among individual genomes exist that identifying mutations responsible for a specific disease has in many cases proven an insurmountable challenge. But now a new study by scientists at The Scripps Research Institute (TSRI), Scripps Health, and Scripps Translational Science Institute (STSI) reveals that by comparing the genomes of diseased patients with the genomes of people with sufficiently similar ancestries could dramatically simplify searches for harmful mutations, opening new treatment possibilities.

The work, reported recently in the journal Frontiers in Genetics: Applied Genetic Epidemiology, should speed the search for the causes of many diseases and provide critical guidance to the genomics field for maximizing the potential benefits of growing genome databases.

Much work is already under way to sequence the DNA of people suffering from diseases with unknown causes, called idiopathic conditions, to find the roots of their problems. Unlike more complex conditions such as diabetes, in some cases a limited number of genetic defects, or even a single mutation, can cause an idiopathic disease. Identifying those critical mutations can lead to effective treatments for previously mysterious problems.

Complicated Searches

While there have been some successes, in many other instances the genetic basis of an idiopathic disease remains elusive. Among other groups, The National Human Genome Research Institute runs searches for idiopathic disease sufferers and is able to find offending gene sequences only about 30 percent of the time. "One explanation for that other 70 percent might be that the diseases are enormously complex," said the new study's senior author Nicholas Schork, a professor at TSRI, director of r
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Physiological Genomics journal announces a major restructuring
2. 2 pioneering plant genomics efforts given a funding boost by National Science Foundation
3. ShanghaiBio Corporation Partners with Ingenuity Systems to Address Challenges in Analysis and Interpretation of Genomics Data
4. Elsevier launches new open access journal: Applied and Translational Genomics
5. The genomics symposium to boost the further development of cancer research
6. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
7. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
8. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
9. SDSCs big data expertise aiding genomics research
10. A new technique to study how myeloids become white blood cells
11. University of Toronto study demonstrates impact of adversity on early life development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New genomics study shows ancestry could help solve disease riddles
(Date:11/7/2014)... 6, 2014 Leading Biometric companies aim ... security revolutionizing online transactions.  Companies in focus today are: NXT-ID, ... BABA ), Google Inc. (NASDAQ: GOOG ... (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: MA) ... NXTDW), a biometric authentication company focused on the growing mobile ...
(Date:11/6/2014)... predator. Except when that predator runs so fast that it ... size, is the fastest creature on Earth. Some of these ... about five miles per hour). The fastest human can do ... the tiger beetle, a person would have to hit 480 ... problem. At peak speeds, everything becomes a blur. They can,t ...
(Date:11/5/2014)... dedicated his career to understanding the Earth,s climate ... , As deputy director and regional climatologist for ... Research Institute, Redmond has more than three decades ... of climate data to the general public. , ... Francisco on December 15-19, 2014 the American Geophysical ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6The tiger beetle: Too fast to see 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... protein known as PEPT2 protects the brains of mice ... present in lead poisoning and in a class of ... Scientists at the University of Michigan found ... (5-ALA), mice without the PEPT2 protein died sooner, had ...
... PARK, MD -- Many fruit farmers in the ... to realize profits and create repeat business. Pick-your-own ... consumer satisfaction with the experience is critical to ... team of researchers from the University of Maryland, ...
... bacteria discovered living in one of the most extreme environments ... global warming. , In a paper published today in the ... Dunfield and colleagues describe the methane-eating microorganism they found in ... of Rotorua in New Zealand. It is the hardiest methanotrophic ...
Cached Biology News:Strawberry fields ripe for the picking 2'Hellish' hot springs yield greenhouse gas-eating bug 2
(Date:11/26/2014)... -- Theravalues Corporation est fier d,annoncer le lancement ... salon Hi Europe 2014 (du 2 au 4 décembre ... Curcumine la plus biodisponible actuellement sur le marché, ... ingrédients approuvés par les règlements européens. ... la racine de curcuma ( Curcuma longa ) ...
(Date:11/24/2014)... , UAE, November 24, 2014 ... "Sheikh Hamdan Bin Rashid Al Maktoum Awards for Medical ... Dubai, United Arab Emirates , on ... ) , The Carter Center which ... Services is actively involved in numerous programs that aim ...
(Date:11/24/2014)... 2014 One of the most extensive, widely ... photonics is now available to high school and junior college ... SPIE, the international society for optics and photonics , announced ... SPIE Digital Library available to high schools for free ... are integral to all areas of life in today’s world,” ...
(Date:11/24/2014)... -- Senior Vice President, General Manager for ... business acumen Elsevier , a world-leading ... services, congratulates Diane Bartoli , Senior Vice President ... Clinical Solutions, for being recognized in the 13 th ... of Profiles in Diversity Journal ® . ...
Breaking Biology Technology:La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Five US Winners Among Recipients of Hamdan Medical Awards 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3