Navigation Links
New genetic variants associated with lipid levels, risk for coronary artery disease
Date:1/13/2008

Environmental and genetic factors influence a persons blood fat, or lipid levels, important risk factors for coronary artery disease (CAD). While there is some understanding of the environmental contribution, the role of genetics has been less defined. Now, in an international collaboration supported primarily by the National Institutes of Health (NIH), scientists have discovered more than 25 genetic variants in 18 genes connected to cholesterol and lipid levels. Seven of the 18 genes previously had not been connected to these levels, while the 11 others confirm previous discoveries. In the investigation, published online January 13 and in the February print issue of Nature Genetics, the associated genes were found through studies of more than 20,000 individuals and more than 2 million genetic variants, spanning the entire genome. These variants potentially open the door to strategies for the treatment and prevention of CAD.

Heart disease is a leading cause of illness, disability and death in industrialized countries, particularly for older people, says National Institute on Aging (NIA) Director Richard J. Hodes, M.D. We know that certain lifestyle factors like smoking, diet and physical activity greatly affect a persons lipid profiles. This study is an important, basic step in finding the genes that influence lipid levels and heart disease so that we can better understand the genetic contribution to cardiovascular risk.

Cristen Willer, Ph.D., at the University of Michigans School of Public Health, Ann Arbor, and Serena Sanna, Ph.D., at the C.N.R. Institute of Neurogenetics and Neuropharmacology, Monserrato, Italy, and other members of the SardiNIA Study of Aging, including investigators at NIA, conducted the study, along with members of the Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) study, which included investigators in North Carolina, Michigan, Finland, Los Angeles and from the Nation
'/>"/>

Contact: Megan Homer
nianews3@mail.nih.gov
301-496-1752
NIH/National Institute on Aging
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... viral diseases in the world for which no pharmaceutical ... is spread by mosquitoes in the tropics, as well ... in Finland and is easily spread by the hands ... the elderly. , Researchers at Aalto University and the ... tests to prevent the spread of one type of ...
(Date:4/15/2014)... cell systems soon could be powering the forklifts used ... and with faster refueling times than ever before, courtesy ... Hydrogen Carriers (HHC). , The goal of the project ... can refuel at low pressure four to five times ... giving hydrogen a competitive advantage over batteries for a ...
(Date:4/14/2014)... swallow, but if you,re over 24 years of age ... cognitive motor performance, according to a new Simon Fraser ... doctoral student, associate professor Mark Blair, Thompson,s thesis supervisor, ... student, deliver the news in a just-published PLOS ... the first social science experiments to rest on big ...
Breaking Biology News(10 mins):Nanocrystalline cellulose modified into an efficient viral inhibitor 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 3Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 4Study says we're over the hill at 24 2
... (SACRAMENTO, Calif.) An international team of scientists led by ... cells is not a one-way street as previously believed. Their ... has a self-correcting mechanism that allows DNA to make a ... appear in the Oct. 23 online issue of the journal ...
... A peer-reviewed study commissioned by NOAA shows the American people ... the coral reefs of the main Hawaiian Islands. ... treasure Hawaii,s coral reefs, even though many never get to ... for oceans and atmosphere and NOAA administrator. "It illustrates the ...
... of Plant Biologists (ASPB) has named 12 plant biology researchers ... Science Master Plant Science Team (MPST). ... research resource that brings together middle and high school students, ... engage in hands-on plant investigations while working with peers at ...
Cached Biology News:UC Davis researchers discover complexities of DNA repair 2US residents say Hawaii's coral reef ecosystems worth $33.57 billion per year 2American Society of Plant Biologists supports science outreach by grad students and postdocs 2American Society of Plant Biologists supports science outreach by grad students and postdocs 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... - Sales in the First Half of 2009 (Excluding ... - Growth in the Pharma Business, - ... Laboratory Glassware, , In the first ... the continuing worldwide economic crisis. This result was,mainly attributable to sales growth ...
... Mass., July 14 Idenix Pharmaceuticals, Inc., (Nasdaq: IDIX ... the second quarter of 2009 on Monday, July 20, 2009 after ... In conjunction with the issuance of the press release, Idenix management ... July 20, 2009 to discuss the company,s financial results for the ...
... , LAKE ZURICH, Ill., July 14 ... blood collection, separation, safety and availability, announced today it has ... to market, sell and distribute Verax,s unique PanGenera(R) Detection (PGD) ... in donated blood platelets. , ...
Cached Biology Technology:Gerresheimer Holds its own in Difficult Environment 2Gerresheimer Holds its own in Difficult Environment 3Gerresheimer Holds its own in Difficult Environment 4Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test 2Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test 3
Mouse polyclonal antibody raised against a partial recombinant WRB. NCBI Entrez Gene ID = 7485...
...
Mouse monoclonal to Casein Kinase 2 beta ( Abpromise for all tested applications). entrezGeneID: 1460 SwissProtID: P13862...
Mouse monoclonal antibody raised against a partial recombinant FAAH. NCBI Entrez Gene ID = FAAH...
Biology Products: