Navigation Links
New genetic link found between normal fetal growth and cancer
Date:4/8/2013

Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.

The work, conducted using mouse and human tissue, appears in today's issue of the Proceedings of the National Academy of Sciences. The authors, Julian C. Lui, Ph.D., and Jeffrey Baron, M.D., work at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

"We've long known that some of the genes that promote rapid growth in prenatal and early postnatal life become reactivated in cancer cells," said Dr. Baron. "Now we've identified a molecular switch that appears to turn on some of these genes, taking us a step forward in understanding normal body growth and the abnormal growth in some types of cancer."

Before birth, a team of more than 200 growth-promoting genes is highly active, fueling the fetus' explosive growth. After birth, these genes are gradually switched off, apparently to slow body growth as we age and approach adult size. In cancer cells, some of these genes can be switched back on.

One of the major growth-promoting genes is called IGF2. This gene is critical for normal prenatal body growth and is reactivated in many types of cancer, showing remarkably high activity in bladder and prostate cancer and some childhood cancers.

For years, scientists did not know what turned IGF2 on and off. Now, using a variety of techniques and tissue types, Drs. Lui and Baron found evidence that a protein known as E2F3 activates the IGF2 gene in normal development and in cancerin particular, in bladder and metastatic prostate cancers.

More broadly, E2F3 appears to regulate not just IGF2, but also many other genes on the body-growth team. When E2F3 levels are high, these genes are active. When E2F3 takes a dive, so do these genes. T
'/>"/>

Contact: Alisa Machalek
alisa.machalek@nih.gov
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Couch potatoes may be genetically predisposed to being lazy, MU study finds
2. Symposium highlights epigenetic effects of milk
3. Genetics Society of Americas Genetics journal highlights for April 2013
4. Researchers discover brain cancer treatment using genetic material from bone marrow cells
5. Study finds strong genetic component to childhood obesity
6. Genetic alterations linked with bladder cancer risk, recurrence, progression, and patient survival
7. Genetic analysis saves major apple-producing region of Washington state
8. Epigenetics studies take root in plants
9. Genetic analysis calls for the protection of 2 highly endangered Portuguese fish species
10. New database to speed genetic discoveries
11. Researchers divide enzyme to conquer genetic puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/10/2015)... Germany , August 10, 2015 ... leader in Eye Tracking Technology for more than two ... Tracking Platform for integration into all consumer display formats. ... for seamless integration of eye tracking into consumer tablets, ... augmented reality smart glasses. Omnivision,s leading sensor technology contributes ...
(Date:8/6/2015)... JOSE, Calif. , Aug. 6, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... TouchPad technologies on Windows 10. Microsoft leveraged Synaptics, ... to the operating system. Through ... drivers are fully certified with Microsoft,s Precision TouchPad ...
(Date:8/4/2015)... Aug. 04, 2015 ... has announced the addition of the ... and Service), Sub-Segment (Computer Forensics, Network Forensics, ... Types, Service, Vertical and Region - Global ... offering. By Component (Hardware, Software, ...
Breaking Biology News(10 mins):SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Synaptics Chosen for Human Interface Co-Development on Windows 10 2Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... can induce a group of aggressive immune cells that ... is the result of a study conducted by Dr. ... Haven and the Broad Institute of the Massachusetts Institute ... Ralf Linker (Dept. of Neurology, University Hospital Erlangen), Professor ...
... today concludes that nearly half of Africa,s wild lion populations ... without urgent conservation measures. The plight of many lion populations ... - and fencing humans out - may be their only ... Minnesota,s Professor Craig Packer and co-authored by a large team ...
... University of Massachusetts Amherst including assistant professor Peter Chien ... degradation help to regulate the delicate ballet of cell ... each other in "mutually assured cleanup" to insure that ... dispose of leftover proteins with the aid of proteases ...
Cached Biology News:International study: Excess dietary salt may drive the development of autoimmune diseases 2International study: Excess dietary salt may drive the development of autoimmune diseases 3New report confirms almost half of Africa's lions facing extinction 2New insight into double-protected dance of cell division 2
(Date:9/2/2015)... , Sept. 2, 2015 Aytu BioScience, Inc. ... treatments for urological and related conditions, announced today that ... private placement convertible note financing, raising a total of ... totaling $3.175 million. Josh Disbrow ... this private placement are intended to be used to ...
(Date:9/2/2015)... Virginia , September 2, 2015 ... der Gewinner des Wettbewerbs BeHEARD von 2015 bekanntgeben ... internationalen vom Rare Genomics Institute. Biovista ... von Medikamenten für die Behandlung anderer Krankheiten als ... Steven Laffoon und sein Team bei ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... equipment, to creating professional commercial video content, to analysis of athletic performance. Producing ... events that go by too quickly to process with the naked eye. ...
(Date:9/1/2015)... CHICAGO , Sept. 1, 2015 The ... of Intent (LOI) for its Discovery Research Grant program. ... 2015 at 12:00 noon CDT. Discovery ... projects with the potential to change current diagnostic or ... These grants specifically encourage novel research at its earliest ...
Breaking Biology Technology:Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2
... assessment to be added to the, ... 28 /PRNewswire-FirstCall/ - Resverlogix Corp. ("Resverlogix" or "Company") ... on activities as well as an interim progress ... is conducting a human Phase 1b/2a clinical trial ...
... Sigma-Aldrich (Nasdaq: SIAL ) today announced the global ... provides a novel and powerful approach to RNAi screening in ... http://www.sigma.com/esirna ) incorporates a pool of hundreds of ... designed to eliminate the trial and error approach of identifying ...
... Techne Corporation,s (Nasdaq: TECH ) consolidated net ... to $27.6 million or $.74 per diluted share compared with ... ended March 31, 2008. For the nine months ended ... $79.9 million or $2.10 per diluted share compared with $76.3 ...
Cached Biology Technology:Resverlogix Provides Quarterly Update 2Resverlogix Provides Quarterly Update 3Resverlogix Provides Quarterly Update 4Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening 2Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening 3Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening 4Techne Corporation Releases Unaudited Third Quarter Results for Fiscal Year 2009 2Techne Corporation Releases Unaudited Third Quarter Results for Fiscal Year 2009 3Techne Corporation Releases Unaudited Third Quarter Results for Fiscal Year 2009 4Techne Corporation Releases Unaudited Third Quarter Results for Fiscal Year 2009 5Techne Corporation Releases Unaudited Third Quarter Results for Fiscal Year 2009 6Techne Corporation Releases Unaudited Third Quarter Results for Fiscal Year 2009 7
Kit contains: Bio-Rad Amplification Reagent, 2x Amplification Diluent, Streptavidin-HRP, Blocking Reagent, and Phosphate Buffered Saline....
Mouse polyclonal antibody to PRDM2 - PR domain containing 2, with ZNF domain...
... Anti-phospho-Hck [pTyr 209/ pSer 211 ] affinity ... in Dulbecco's phosphate buffered saline (without Mg 2+ ... 1.0 mg/ml BSA (IgG and protease free) and ... from the region of mouse Hck that contains ...
... Useful as a positive control for ... to chromatin in vivo is a crucial ... extent of crosslinking is probably the most ... subsequent immunoprecipitation step should be taken into ...
Biology Products: