Navigation Links
New genetic link found between normal fetal growth and cancer
Date:4/8/2013

Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.

The work, conducted using mouse and human tissue, appears in today's issue of the Proceedings of the National Academy of Sciences. The authors, Julian C. Lui, Ph.D., and Jeffrey Baron, M.D., work at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

"We've long known that some of the genes that promote rapid growth in prenatal and early postnatal life become reactivated in cancer cells," said Dr. Baron. "Now we've identified a molecular switch that appears to turn on some of these genes, taking us a step forward in understanding normal body growth and the abnormal growth in some types of cancer."

Before birth, a team of more than 200 growth-promoting genes is highly active, fueling the fetus' explosive growth. After birth, these genes are gradually switched off, apparently to slow body growth as we age and approach adult size. In cancer cells, some of these genes can be switched back on.

One of the major growth-promoting genes is called IGF2. This gene is critical for normal prenatal body growth and is reactivated in many types of cancer, showing remarkably high activity in bladder and prostate cancer and some childhood cancers.

For years, scientists did not know what turned IGF2 on and off. Now, using a variety of techniques and tissue types, Drs. Lui and Baron found evidence that a protein known as E2F3 activates the IGF2 gene in normal development and in cancerin particular, in bladder and metastatic prostate cancers.

More broadly, E2F3 appears to regulate not just IGF2, but also many other genes on the body-growth team. When E2F3 levels are high, these genes are active. When E2F3 takes a dive, so do these genes. T
'/>"/>

Contact: Alisa Machalek
alisa.machalek@nih.gov
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Couch potatoes may be genetically predisposed to being lazy, MU study finds
2. Symposium highlights epigenetic effects of milk
3. Genetics Society of Americas Genetics journal highlights for April 2013
4. Researchers discover brain cancer treatment using genetic material from bone marrow cells
5. Study finds strong genetic component to childhood obesity
6. Genetic alterations linked with bladder cancer risk, recurrence, progression, and patient survival
7. Genetic analysis saves major apple-producing region of Washington state
8. Epigenetics studies take root in plants
9. Genetic analysis calls for the protection of 2 highly endangered Portuguese fish species
10. New database to speed genetic discoveries
11. Researchers divide enzyme to conquer genetic puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... is one of the products featured in 2015 "I ... at 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 ...
(Date:3/17/2015)... MINNETONKA, Minn. , March 17, 2015 /PRNewswire/ ... sciences technology company specializing in clinical study management ... will be in attendance at ARENA,s Outsourcing in ... Cary, NC.  This event provides an excellent forum ... company,s easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical ...
(Date:3/12/2015)... -- IriTech, a leading iris based identity management technology ... Design Network, announced today that the Chief Minister ... MK2120U device during a launching event of Andhra Pradesh ... The iris scanner is manufactured by U.S. based ... India through its Indian partner, Biometronic Technology, ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3
... A UT Southwestern Medical Center program designed to teach ... received $700,000 from the Howard Hughes Medical Institute (HHMI). ... supports a program begun in 2008 by Dr. Helen ... scientists could greatly affect human health if they communicated ...
... songs blue whales sing across the vast expanses of the ... for the past few decades, and a scientist at Scripps ... believe the trend may be good news for the population ... in Bellvue, Colo., along with John Hildebrand of Scripps Oceanography ...
... In a paper published this week in the journal ... Michael Kobor reported the structure and function of a key ... Kobor is a UBC assistant professor of medical genetics and ... at the Child & Family Research Institute. Chromatin, a ...
Cached Biology News:UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students 2The pitch of blue whale songs is declining around the world, scientists discover 2The pitch of blue whale songs is declining around the world, scientists discover 3
(Date:3/31/2015)... 31, 2015 Pittcon 2015, the 66th ... ended on March 12, in New Orleans with an ... as estimated by the New Orleans Convention and Visitor's ... conferees and exhibitor personnel. Those who attended Pittcon ... number. For the third year, the co-location of Food ...
(Date:3/31/2015)... DALLAS and NEW YORK ... Inc. (NASDAQ: PTBI ), a biopharmaceutical company ... products, announced today that its Korean marketing partner, ... received marketing approval in Korea from the country,s ... the Korea Testing & Research Institute (KTR) for ...
(Date:3/31/2015)... 2015 Lighthouse Information Systems, Inc., ... in California, Oregon, Washington and clients across the ... and Acquisition (M&A) Integration Services offering, effective immediately. ... Services and M&A Integration Practice Leader at Lighthouse, ... majority of M&A initiatives fail to achieve their ...
(Date:3/30/2015)... , March 30, 2015  NuGene International, Inc. ... corporation, NuGene BioPharma, Inc. has added another internationally ... Dr. Guan is an internationally recognized researcher in ... college education at Peking University, China ... from the University of North Carolina, Chapel Hill. ...
Breaking Biology Technology:Pittcon 2015 Hits the Big Easy in a Big Way 2Pittcon 2015 Hits the Big Easy in a Big Way 3Pittcon 2015 Hits the Big Easy in a Big Way 4PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 2PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 3Lighthouse Information Systems, Inc., Announces Addition of M&A Integration Services 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 3
... — Sonic Foundry posted mixed financial numbers for the ... still posting a net loss. , ,Revenues were $8.3 million, ... unit sales up 74 percent, owing to multiple unit sales, ... ,Operating expenses increased by 20 percent, however, and the company ...
... — A report from the Association of University Technology ... Research Foundation third in the country in value of ... the University of California System, counted as a single entity ... 300 different universities that have technology transfer offices, and to ...
... for DEMO 2006 nears, Ive had plenty of conversations with ... ,Does a product in "beta" variously defined as the ... launch-ready? Must I have customers in the queue and ready ... product that we've only talked about with our first 10 ...
Cached Biology Technology:UW-Madison third in nation in tech-transfer value 2When do you go from "beta" to "product launch"? 2When do you go from "beta" to "product launch"? 3
...
Mouse monoclonal [7A6] to NFAT2 ( Abpromise for all tested applications). entrezGeneID: 4772 SwissProtID: O95644...
Carbonate-Bicarbonate Buffer Capsules. For use in coating ELISA plates. Dissolve contents of 1 capsule in 100 ml deionized water to yield 0.05 M carbonate-bicarbonate buffer, pH 9.6....
...
Biology Products: