Navigation Links
New genes for short-sightedness identified
Date:2/10/2013

An international team of scientists led by King's College London has discovered 24 new genes that cause refractive errors and myopia (short-sightedness).

Myopia is a major cause of blindness and visual impairment worldwide, and currently there is no cure. These findings, published today in the journal Nature Genetics, reveal genetic causes of the trait, which could lead to finding better treatments or ways of preventing the condition in the future.

Thirty per cent of Western populations and up to 80 per cent of Asian people suffer from myopia. During visual development in childhood and adolescence the eye grows in length, but in myopes it grows too long, and light entering the eye is then focused in front of the retina rather than on it. This results in a blurred image. This refractive error can be corrected with glasses, contact lenses or surgery. However, the eye remains longer, the retina is thinner, and this may lead to retinal detachment, glaucoma or macular degeneration, especially with higher degrees of myopia. Myopia is highly heritable, although up to now, little was known about the genetic background.

To find the genes responsible, researchers from Europe, Asia, Australia and the United States collaborated as the Consortium for Refraction and Myopia (CREAM). They analysed genetic and refractive error data of over 45,000 people from 32 different studies, and found 24 new genes for this trait, and confirmed two previously reported genes. Interestingly, the genes did not show significant differences between the European and Asian groups, despite the higher prevelance among Asian people. The new genes include those which function in brain and eye tissue signalling, the structure of the eye, and eye development. The genes lead to a high risk of myopia and carriers of the high-risk genes had a tenfold increased risk.

It was already known that environmental factors, such as reading, lack of outdoor exposure,
'/>"/>

Contact: Katherine Barnes
katherine.barnes@kcl.ac.uk
44-207-848-3076
King's College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Evaluating evolutionary rates could shed light into functions of uncharacterized genes
2. 1 of the key circuits in regulating genes involved in producing blood stem cells is deciphered
3. Evidence mounts for role of mutated genes in development of schizophrenia
4. First in the world - Singapore scientists discover genes responsible for cornea blindness
5. A history lesson from genes
6. International study suggests human genes influence gut microbial composition
7. Rare form of active jumping genes found in mammals
8. More than 200 genes identified for Crohns Disease
9. Steroid hormone receptor prefers working alone to shut off immune system genes
10. Different genes behind same adaptation to thin air
11. METACARDIS: a European project that deciphers the genes of the gut microbiota
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
(Date:9/30/2014)... (LMU) in Munich report that a new class ... to chemotherapeutic drugs. They have also pinpointed the ... for anti-tumor agents. , Researchers led by ... of the Technische Universitt Mnchen have identified a ... weapon in the fight against malignant tumors. The ...
(Date:9/30/2014)... of perilous threats in today,s ocean. From overfishing ... fragile coral ecosystems are disappearing at unprecedented rates ... of corals surrounding the island of Moorea in ... tropical environment: coral guard-crabs. New research from the ... scientist Seabird McKeon and the museum,s predoctoral fellow ...
Breaking Biology News(10 mins):NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2Cancer therapy: Driving cancer cells to suicide 2Smithsonian scientists discover coral's best defender against an army of sea stars 2
... Smart Search & Match,the leading provider of high-performance ... has joined the company as Product Marketing Manager. ... 15 years of product and marketing management,experience to ... many high-tech products and solutions worldwide. He has ...
... the human body in ways never imagined only a ... population of patients who are newly susceptible to opportunistic ... formidable clinical opponent, and foremost among them is ... from ASM Press. "This volume has been ...
... of the global population living in cities reached 50 ... exciting new book series which brings together leading experts ... all over the world. The aim of the ... facing the architects, planners, developers and inhabitants of the ...
Cached Biology News:New text focuses on formidable opportunistic fungus 2Springer looks ahead to the Future City 2
(Date:10/1/2014)... , October 1, 2014 ... software invited to engage around the theme, ,Commercial Opportunities ...   Elsevier , a ... and services, will host a gathering of some of ... and trends impacting healthcare today and in the future. ...
(Date:9/30/2014)... Applying a well-known optical phenomenon called thin-film interference, ... demonstrated the ability to "paint" ultra-thin coatings onto ... for making future, flexible electronic devices, creating advanced ... rocket ships and spacecraft with extremely lightweight decorative ... water, it becomes iridescent, revealing a myriad of ...
(Date:9/30/2014)... of one of nature,s most efficient light-harvesting structures, ... by Alejandro Briseno of the University of Massachusetts ... long-sought polymer architecture to boost power-conversion efficiency of ... , Briseno, with colleagues and graduate students ... and Dresden University of Technology, Germany, report in ...
(Date:9/30/2014)... Report Details Biosimilar drugs – ... Do you want to find sales potentials of ... for those biological drugs from 2014, helping you ... data, R&D trends, opportunities and selling prospects. In ... 2024 at overall world market, therapeutic class, molecule ...
Breaking Biology Technology:Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Taking thin films to the extreme 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5
... scientists observe a reaction moving at greater than 10 meters ... feat some would say is nearly impossible. But ... dynamic transmission electron microscope (DTEM). DTEM,s ability to ... it,s happening has earned it one of the 10 winning ...
... , Aug. 2 Octapharma USA today ... is the Rush Hemophilia & Thrombophilia Center at Rush ... focused on human protein therapies in hematology, immune therapy, intensive care and emergency ... Leonard A. ...
... Aug. 2 Tengion Inc. (Nasdaq: TNGN ... to the position of Chief Financial Officer.  Mr. Davis comes to Tengion ... technologies to develop improved protein therapeutics. At its peak, Neose employed 200 ... , , ...
Cached Biology Technology:Livermore's DTEM earns innovation award from Microscopy Today 2Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 2Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 3Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 4Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 5Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 6Tengion Appoints A. Brian Davis Chief Financial Officer 2
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Peptide-affinity Purified Polyclonal Antibody to MTR...
Polyclonal Antibody to AGAP1 / Centaurin, gamma 2...
Polyclonal Antibody to PRG3...
Biology Products: