Navigation Links
New gene variant may explain psychotic features in bipolar disorder
Date:3/5/2013

Researchers at Karolinska Institutet in Sweden have found an explanation for why the level of kynurenic acid (KYNA) is higher in the brains of people with schizophrenia or bipolar disease with psychosis. The study, which is published in the scientific periodical Molecular Psychiatry, identifies a gene variant associated with an increased production of KYNA. The discovery contributes to the further understanding of the link between inflammation and psychosis and might pave the way for improved therapies.

Kynurenic acid (KYNA) is a substance that affects several signalling pathways in the brain and that is integral to cognitive function. Earlier studies of cerebrospinal fluid have shown that levels of KYNA are elevated in the brains of patients with schizophrenia or bipolar diseases with psychotic features. The reason for this has, however, not been fully understood.

KMO is an enzyme involved in the production of KYNA, and the Karolinska Institutet team has now shown that some individuals have a particular genetic variant of KMO that affects its quantity, resulting in higher levels of KYNA. The study also shows that patients with bipolar disease who carry this gene variant had almost twice the chance of developing psychotic episodes.

KYNA is produced in inflammation, such as when the body is exposed to stress and infection. It is also known that stress and infection may trigger psychotic episodes. The present study provides a likely description of this process, which is more likely to occur in those individuals with the gene variant related to higher production of KYNA. The researchers also believe that the discovery can help explain certain features of schizophrenia or development of other psychotic conditions.

"Psychosis related to bipolar disease has a very high degree of heredity, up to 80 per cent, but we don't know which genes and which mechanisms are involved," says Martin Schalling, Professor of medical genetics at Karolinska Institutet's Department of Molecular Medicine and Surgery, also affiliated to the Center for Molecular Medicine (CMM). "This is where our study comes in, with a new explanation that can be linked to signal systems activated by inflammation. This has consequences for diagnostics, and paves the way for new therapies, since there is a large arsenal of already approved drugs that modulate inflammation."


'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. Common genetic variants identify autism risk in high risk siblings of children with ASD
2. Ingenuity Variant Analysis Sees Exponential Customer Adoption
3. Dopamine-receptor gene variant linked to human longevity
4. Surprising pine beetle breeding habits help explain increasing tree damage, says CU study
5. Computer simulations help explain why HIV cure remains elusive
6. Genetic variation in East Asians found to explain resistance to cancer drugs
7. Growing nitrous oxide levels explained
8. Overweight? New research explains how proper sleep is important for healthy weight
9. A cells first steps: Building a model to explain how cells grow
10. Scientists start explaining Fat Bastards vicious cycle
11. The appetite-suppressing effect of proteins explained
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... Participants of this educational ... fume hood. Along with the advantages and disadvantages of ductless, filtered fume hoods, ... in the laboratory. , Attendees will learn from an industry expert about the ...
(Date:9/19/2017)... ... September 19, 2017 , ... VetStem Biopharma ’s CEO and founder, Dr. Bob ... in Riordan’s new book "Stem Cell Therapy: A Rising Tide". Dr. Harman and Dr. ... They bonded over an interest in the potential of stem cell therapy and a fast ...
(Date:9/19/2017)... ... September 19, 2017 , ... One ... about to be eliminated, said Lyle Probst, President, CEO and Founder of ... different than other pathogen detection solutions, Probst said, “Sample preparation takes place inside ...
(Date:9/19/2017)... ... September 19, 2017 , ... Avomeen Analytical Services, an ... its 2017 Science Student Award. The scholarship program is dedicated to helping those ... defray the costs of obtaining their science education. , Avomeen began the annual ...
Breaking Biology Technology: