Navigation Links
New gene variant identified for nondiabetic end stage renal disease in African-Americans
Date:9/14/2008

Scientists at Johns Hopkins schools of Public Health and Medicine have, for the first time, identified variants in the gene MYH9 that are associated with increased risk for non-diabetic end stage renal disease (ESRD,) which is the near-loss of kidney function leading to either dialysis of transplant. MYH9, located on the 22 chromosome, is the first gene identified for common forms of kidney disease. The study was published online September 14 in the journal Nature Genetics and will be published in the October print edition. In a separate study published in the same issue, researchers at the National Institutes of Health reported similar findings.

In the United States, about 26 million Americans have chronic kidney disease with nearly 427,000 Americans requiring dialysis or kidney transplant each year for the treatment of ESRD, according to U.S. government studies. African Americans are affected disproportionately as they have a four-times-higher incidence of end stage renal disease compared to European Americans.

"We are in the midst of an epidemic of chronic kidney disease, in which African Americans are disproportionately affected. This finding does not mean that non-genetic factors, such as socioeconomic indicators and other factors do not contribute to the higher risk of kidney disease in African Americans. It defines a subset of persons most likely vulnerable to the harmful effect of these factors," said study author Michael J. Klag, MD, MPH, dean of the Johns Hopkins Bloomberg School of Public Health.

"Our results show that in addition to environmental and behavioral risk factors, genetic factors play a role as well," said lead author, Linda Kao, PhD, MHS, associate professor in Bloomberg School of Public Health's Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research.

"While we know these genetic variations are common among African Americans, not everyone with the va
'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic variant increases triglyceride levels in Asian-Americans
2. Genetic variant mimics effect of heart failure medications
3. New vaccine may give long-term defense against deadly bird flu and its variant forms
4. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
5. Gene variant increases breast cancer risk
6. New genetic variants associated with lipid levels, risk for coronary artery disease
7. Scientists associate 6 new genetic variants with heart disease risk factor
8. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
9. Breastfeeding boost IQ in infants with helpful genetic variant
10. New genetic variant associated with prostate cancer in African-Americans
11. Genetic variant linked to odor perception
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... State University engineer has developed a patented technique ... explosive devices. The same technique could help police ... M. and Kay L. Theede chair in engineering ... and his research team have created a template-based ... car trunks. The distance detection method called ...
(Date:4/17/2014)... release is available in German . ... pay the protection money demanded of him, he can expect ... required, however, as fear of the consequences is enough to ... in parasitic birds, which lay their eggs in other birds, ... the brood parasites take their revenge by destroying the entire ...
(Date:4/17/2014)... conditions such as heart disease, epilepsy and pain, making ... there is still much scientists do not know about ... insight into the structure of sodium channels and, specifically, ... are responsible for ,fine-tuning, the activity of the channel. ... of the Journal of Biological Chemistry . , ...
Breaking Biology News(10 mins):Patented research remotely detects nitrogen-rich explosives 2Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Structure of sodium channels different than previously believed 2
... a devastating wheat fungus isn,t threatening the state,s crops yet. ... the U.S. Department of Agriculture to keep it that way. ... leading a group of researchers to study the wheat blast ... Brazil. "We don,t know if our varieties in Kansas ...
... In the rogues, gallery of microscopic infectious agents, the prion ... both DNA and RNA, prions are believed to cause such ... and moose, mad cow disease in cattle, scrapie in sheep ... the weirdest infectious agent know to science, the prion is ...
... repair patterns may increase risk of pancreatic cancer by as ... 77 percent, depending on the genes involved, according to a ... Clinical Cancer Research , a journal of the American Association ... in late stages, and thus is resistant to most available ...
Cached Biology News:Researchers to use K-State's BSL-3 Lab for $1 million study of fungus threatening wheat crops 2Researchers to use K-State's BSL-3 Lab for $1 million study of fungus threatening wheat crops 3Common soil mineral degrades the nearly indestructible prion 2
(Date:1/14/2014)... SAN DIEGO and BETHESDA, Md. ... they are joining together with two institutes from the ... more reliable tools for bringing safer, more effective treatments ... with the National Center for Advancing Translational Sciences (NCATS) ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
(Date:1/14/2014)... January 14, 2014 Global Record ... innovative information technology solutions for patients, physicians, the ... stakeholders, announced today the signing of a three-year ... and Drug Administration (FDA). This initiative is ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... ANDS ) announced today that it will present ... on Tuesday,March 4, 2008 at 4:30 p.m. EST (1:30 ... Hotel in New York., Steve Worland, Ph.D., President ... an overview of Anadys and its two,development-stage product candidates, ...
... Vermillion, Inc.,(Nasdaq: VRML ) announced that on February ... Market LLC that indicated the Company is not in,compliance ... (i),a minimum of $2,500,000 in stockholders, equity; (ii) $35,000,000 ... net income from continuing,operations for the most recently completed ...
... Ltd., a wholly owned subsidiary of Forest Laboratories, ... and Mylan Inc. (NYSE: MYL ) have,amended ... the novel beta blocker Bystolic(TM) (nebivolol), which is,currently ... of hypertension.,The companies have agreed that Forest will ...
Cached Biology Technology:Anadys Pharmaceuticals to Present at the Susquehanna SIGnificant Options in Healthcare Conference 2Vermillion Receives NASDAQ Notice of Non-Compliance 2Forest Laboratories, Inc. Announces Amendment to Bystolic(TM) (nebivolol) Agreement 2Forest Laboratories, Inc. Announces Amendment to Bystolic(TM) (nebivolol) Agreement 3
Phospho- (Ser) 14-3-3 Binding Motif (4E2) Mouse mAb...
Rat polyclonal to acetyl Salicylic Acid ( Abpromise for all tested applications)....
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody...
Rabbit polyclonal to UBC12 (rating: ****) ( Abpromise for all tested applications). Antigen: Synthetic peptide: RGGYIGSTYFER, corresponding to amino acids 169-180 of UBC12 Entrez Gene ID: 90...
Biology Products: