Navigation Links
New gene associated with increased risk of Alzheimer's disease

TORONTO Researchers have identified a gene that appears to increase a person's risk of developing late-onset Alzheimer's disease, the most common type of Alzheimer's disease. The research will be presented as part of the late-breaking science program at the American Academy of Neurology's 62nd Annual Meeting in Toronto, April 10 17, 2010. The gene, abbreviated MTHFD1L, is located on chromosome six.

"Only recently have common variants in genes other than APOE been convincingly shown to be associated with a person's risk of developing late-onset Alzheimer's disease," said senior author Margaret Pericak-Vance, PhD, the principal investigator of the study and Director of the University of Miami Miller School of Medicine's John P. Hussman Institute for Human Genomics in Miami, Florida.

Researchers looked at gene variation throughout the human genomes of 2,269 people with late-onset Alzheimer's disease and 3,107 people without the disease through what's known as a genome-wide association study. Such studies involve looking at long stretches of DNA to identify small differences in the genetic sequence between people with and without Alzheimer's disease.

The study found that individuals with a particular variation in the gene MTHFD1L may be almost twice as likely to develop Alzheimer's disease as those people without the variation. "We are hopeful our identification of MTHFD1L as a risk gene for Alzheimer's disease will help us to better understand how this disease develops and potentially serve as a marker for people who may be at increased risk," said Adam Naj, PhD, with the University of Miami Miller School of Meidicne's John P. Hussman Institute for Human Genomics in Miami and the first author of the abstract reporting the discovery.

"Identifying this gene is important because the gene is known to be involved in influencing the body's levels of homocysteine, and high levels of homocysteine are strong risk factor for late-onset Alzheimer's disease," said Pericak-Vance. "In addition, variations of the MTHFD1L gene have been reported to possibly increase the risk of coronary artery disease. Since the function of blood vessels in the brain may affect Alzheimer's disease, this finding may also help us understand how homocysteine levels and blood vessel function in the brain affect Alzheimer's disease."

The World Health Organization estimates that there are currently 18 million people worldwide with Alzheimer's disease, and this figure is projected to nearly double to 34 million by 2025. There are currently at least five million Americans living with Alzheimer's disease today.


Contact: Rachel Seroka
American Academy of Neurology

Related biology news :

1. Depression associated with sustained brain signals
2. Scientists identify age-associated defects in schizophrenia
3. Study finds variations in 1 gene may be associated with endurance running
4. Epigenetics could help researchers determine any risks associated with low-dose radiation
5. New gene variants associated with glucose, insulin levels, some with diabetes risk
6. Consumption of certain fish during pregnancy associated with poorer cognitive performance
7. Attention-deficit/hyperactivity problems associated with low folate levels in pregnant women
8. New chromosomal abnormality identified in leukemia associated with Down syndrome
9. Mediterranean diet associated with reduced risk of depression
10. Study finds 231 new genes associated with head and neck cancer
11. Barrow scientist awarded $400,000 grant to study cell associated with intuition and autism
Post Your Comments:
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: ) ... provide their customers enhanced security to access and ...
(Date:4/15/2016)... April 15, 2016 Research ... Gait Biometrics Market 2016-2020,"  report to their offering.  ... ) , ,The global gait biometrics market is ... during the period 2016-2020. Gait analysis ... can be used to compute factors that are ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) ... precise treatments and faster cures for prostate cancer. Members of the Class of ... 15 countries. Read More About the Class of 2016 ... ... ...
Breaking Biology Technology: