Navigation Links
New gene associated with increased risk of Alzheimer's disease
Date:4/14/2010

TORONTO Researchers have identified a gene that appears to increase a person's risk of developing late-onset Alzheimer's disease, the most common type of Alzheimer's disease. The research will be presented as part of the late-breaking science program at the American Academy of Neurology's 62nd Annual Meeting in Toronto, April 10 17, 2010. The gene, abbreviated MTHFD1L, is located on chromosome six.

"Only recently have common variants in genes other than APOE been convincingly shown to be associated with a person's risk of developing late-onset Alzheimer's disease," said senior author Margaret Pericak-Vance, PhD, the principal investigator of the study and Director of the University of Miami Miller School of Medicine's John P. Hussman Institute for Human Genomics in Miami, Florida.

Researchers looked at gene variation throughout the human genomes of 2,269 people with late-onset Alzheimer's disease and 3,107 people without the disease through what's known as a genome-wide association study. Such studies involve looking at long stretches of DNA to identify small differences in the genetic sequence between people with and without Alzheimer's disease.

The study found that individuals with a particular variation in the gene MTHFD1L may be almost twice as likely to develop Alzheimer's disease as those people without the variation. "We are hopeful our identification of MTHFD1L as a risk gene for Alzheimer's disease will help us to better understand how this disease develops and potentially serve as a marker for people who may be at increased risk," said Adam Naj, PhD, with the University of Miami Miller School of Meidicne's John P. Hussman Institute for Human Genomics in Miami and the first author of the abstract reporting the discovery.

"Identifying this gene is important because the gene is known to be involved in influencing the body's levels of homocysteine, and high levels of homocysteine are strong risk factor for late-onse
'/>"/>

Contact: Rachel Seroka
rseroka@aan.com
651-695-2738
American Academy of Neurology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Depression associated with sustained brain signals
2. Scientists identify age-associated defects in schizophrenia
3. Study finds variations in 1 gene may be associated with endurance running
4. Epigenetics could help researchers determine any risks associated with low-dose radiation
5. New gene variants associated with glucose, insulin levels, some with diabetes risk
6. Consumption of certain fish during pregnancy associated with poorer cognitive performance
7. Attention-deficit/hyperactivity problems associated with low folate levels in pregnant women
8. New chromosomal abnormality identified in leukemia associated with Down syndrome
9. Mediterranean diet associated with reduced risk of depression
10. Study finds 231 new genes associated with head and neck cancer
11. Barrow scientist awarded $400,000 grant to study cell associated with intuition and autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... help reduce or reverse soil subsidence and reduce ... Sacramento-San Joaquin River Delta by Dartmouth College researchers ... one of the first to continually measure the ... cycle through wetlands, appears in the journal by ... Worldwide, agricultural drainage of organic soils has resulted ...
(Date:10/30/2014)... This news release is available in German . ... we as individuals prompt our fellow humans to behave ... to social dilemmas in game theory. Previous studies assumed ... large groups. Nonetheless, scientists from the Max Planck Institute ... us can exert an influence on the cooperative behaviour ...
(Date:10/30/2014)... State University researchers have developed a suite of technologies ... and humans, which has applications in everything from search ... , "We,ve developed a platform for computer-mediated communication between ... avenues for interpreting dogs, behavioral signals and sending them ... Roberts, an assistant professor of computer science at NC ...
Breaking Biology News(10 mins):Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4New tech aims to improve communication between dogs and humans 2
... German . , , "Watch out, it,ll hurt for a ... they hear those words from their doctor. And, as soon as ... very clearly. "After such an experience it is enough to simply ... pain memory", knows Prof. Dr. Thomas Weiss from the Friedrich-Schiller-University Jena. ...
... toads, salamanders, and newtsare disappearing worldwide, but the stream ... This region is home to the largest diversity of ... here), and scientists want to understand what contributes to ... in the March 29, 2010 issue of the ...
... Bionic Vision Australia (BVA) today unveils their wide-view ... implanted into Australia,s first recipient of the technology. ... at the University of New South Wales and unveiled ... University of Melbourne, will deliver improved quality of life ...
Cached Biology News:Do words hurt? 2Young salamanders' movement over land helps stabilize populations 2Young salamanders' movement over land helps stabilize populations 3Bionic Vision Australia puts bionic eye in sight 2
(Date:10/30/2014)... – The severe flooding that devastated a wide swath ... if the bridges, roads and other infrastructure had been ... the University of Colorado Denver. , "People need to ... Kim, PhD, associate professor of structural engineering at the ... lead author the study. "There is an assumption that ...
(Date:10/27/2014)... October 27, 2014 The new ... Type (High & Medium), Sub-type (Primary & Secondary), ... Infrastructure & Transportation & Power Generation) - Trends ... GIS market with analysis and forecasting of the ... Data Tables with 52 Figures spread through 146 ...
(Date:10/27/2014)... TORONTO , Oct. 27, 2014 ... today announced two presentations demonstrating that the extent ... proprietary cancer immunotherapeutic AE37 vaccine correlated with a ... AE37 cancer vaccine is being developed by the ... ). The presentations are being made at the ...
(Date:10/27/2014)... 2014 The “Molecular Diagnostic Market ... Technology (PCR, INAAT, DNA Sequencing), End User (Hospital, ... - Global Forecast to 2018” provides a detailed ... current market trends, and strategies impacting the global ... forecasts of the revenue and share analysis. , ...
Breaking Biology Technology:CU Denver study says upgrading infrastructure could reduce flood damage 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5
... PARI Respiratory Equipment,s,breath-enhanced nebulizer, the PARI ... L.P.,s new COPD medication, Perforomist Inhalation Solution,that ... subsidiary of Mylan Inc.,(NYSE: MYL ). ... indicated for,long-term, twice-daily maintenance treatment of bronchoconstriction ...
... WASHINGTON, D.C., October 9 Bavarian Nordic,the Danish-based ... of Health and Human Services (HHS) to,invoice an ... the recent,contract (RFP-3)* to manufacture and deliver 20 ... HHS approved the advance payment because Bavarian Nordic ...
... Patient-Safety ... Technology,eRx NOW(TM) Functionality Expanded to ... Physician Portal Lab Order and Results Capabilities, LYNDHURST, N.J. and ... leading provider of,diagnostic testing, information and services and a leading developer of,healthcare ...
Cached Biology Technology:PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 2PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 3PARI Respiratory's LC PLUS & PRONEB Ultra Deliver Dey, L.P.'s New COPD Therapy; Perforomist Launched Yesterday 4Bavarian Nordic Receives $50 Million Advance Payment from HHS for Fulfilling Contract Milestones 2Bavarian Nordic Receives $50 Million Advance Payment from HHS for Fulfilling Contract Milestones 3Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 2Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 3Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 4Quest Diagnostics Joins National ePrescribing Patient Safety Initiative (NEPSI) 5
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
... The LX80L is an extension of Parkers ... maintaining a compact cross-section. LX80L bolt hole patterns ... mount MX80 units and all accessory brackets to ... stage with travel to 750 mm , Accelerations ...
... PEP-005 is a synthetic peptide whose sequence is from the C-terminal end ... acid sequence extends from amino acids 429 to 448 of RAR*. ... - S - V - S - P - S - S ... - S - Q - S - P - L - L ...
... Rat Neural Stem Cell Kit with ... cells (NCSs) complete with optimized base medium ... and plate these unique cells generated from ... you need for a tissue-like mixture of ...
Biology Products: