Navigation Links
New drug agent knocks out multiple enzymes in cancer pathway
Date:3/25/2009

to the use of multi-kinase inhibitors in cancer therapy.

Andrew Wang, of Academia Sinica, Taipei, and Illinois chemist Rong Cao began by producing crystallographic structures of the target enzymes and drug candidates, allowing the researchers to identify those features that would enhance the drugs' ability to bind to the enzymes. Using this and other chemical data, Illinois chemistry department research scientist Yonghui Zhang engineered new bisphosphonate compounds that bound tightly to multiple enzyme targets, but not to bone.

One of the new compounds, called BPH-715, proved to be especially potent in cell culture and effectively inhibited tumor cell growth and invasiveness.

Tadahiko Kubo, of Hiroshima University, then found that BPH-715 also killed tumor cells in mice. And Socrates Papapoulos, of Leiden University, the Netherlands, showed that the compound had a very low chemical affinity for bone.

In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells called gamma delta T-cells, which aid in killing tumor cells.

"The new drugs are about 200 times more effective than the drugs used in recent clinical trials at killing tumor cells and in activating gamma delta T-cells to kill tumor cells," Oldfield said. "They also prevent tumor progression in mice much better than do existing bisphosphonate molecules."


'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Structure of enzyme against chemical warfare agents determined
2. Chemopreventive agents in black raspberries identified
3. MIT nanotubes sniff out cancer agents in living cells
4. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
5. Certain anticancer agents could be harmful to patients with heart disease
6. UF researchers develop improved gene therapy agent
7. New insights into the diversity of Creutzfeldt-Jakob disease agents
8. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
9. Contrast agent trials in swine
10. Agent that triggers immune response in plants is uncovered
11. Primate behavior explained by computer agents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New drug agent knocks out multiple enzymes in cancer pathway
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Saudi Arabia Biomedical Sensors Market - Growth, ... The Saudi Arabia Biomedical Sensors market ... CAGR of 3.64% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:8/24/2015)... VIEW, Calif. , Aug. 24, 2015  Based on ... Sullivan recognizes DERMALOG with the 2015 African Biometrics Company of ... and has achieved substantial commercial success in Africa ... Nigeria , where it has implemented one of the ... 23 banks as well as the Central Bank of ...
(Date:8/18/2015)... Aug. 18, 2015  Navitas today announced ... to the Submission Content Management webinar scheduled ... non-profit forum. Dedicated to the Implementation of Regulatory ... platform for industry, vendors, health authorities, consultants ... work towards a standard method of implementing ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3
... Tall fescue toxicosis is one of the most ... no cure for this costly disorder, there are proven ... new professional guide, Tall Fescue Toxicosis and Management is ... want to better understand and control toxicosis. "We ...
... NY, June 15 Robert H. Wurtz, PhD, a pioneer ... of the 2010 Neuroscience Prize of The Peter and Patricia ... information and controls eye movements laid the groundwork for subsequent ... led scientists to a deeper understanding of how the brain ...
... of dedicated South Florida researchers from the University of ... and the National Oceanic and Atmospheric Administration,s Atlantic Oceanographic ... whether oil was, as predicted, being pulled into the ... The University of Miami,s 96-foot catamaran ...
Cached Biology News:Neuroscientist Robert H. Wurtz receives the $500,000 Gruber neuroscience prize 2Neuroscientist Robert H. Wurtz receives the $500,000 Gruber neuroscience prize 3Scientists locate oil plume extending toward Dry Tortugas 2Scientists locate oil plume extending toward Dry Tortugas 3
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... Park ... additive manufacturing on Sept. 17, 2015 at 9am PST. The webinar will focus on ... More popularly known as 3D printing, additive manufacturing is a broad term that encompasses ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... systems, analytical testing, education and consulting services for the medical device sector, ... products/processes development, design control, validation, quality assurance and regulatory compliance. Avarent will ...
(Date:9/2/2015)... 2015 Research and Markets ... PharmaBiotech,s new report "Gene Therapy - Technologies, Markets ... markets for gene therapy are difficult to estimate as ... it is marketed in China ... years 2014-2024. The estimates are based on epidemiology of ...
(Date:9/2/2015)... Australian prostate cancer technology company Minomic International Ltd has ... science that uses its patented antibody. The ... cancer diagnostic test known as MiCheck® next year, was ... peer-reviewed Australian Museum Eureka Science Prize for Excellence ... is awarded for ground breaking research that has only ...
Breaking Biology Technology:Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 2Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3
... Brookfield-based Fiserv, Inc. , has ... management and billing software for large and mid-sized ... ,Interactive Technologies, headquartered in Summit, New Jersy, develops ... management companies, depositories, exchanges and other high-end providers ...
... clinical technologies in healthcare does not absolve physicians and ... when technology vendors include strong sales contract disclaimers. , ... more directly to consumers, they will assume more liability ... Digital Healthcare Conference in Madison were told. ...
... and the progress of six regional firms were discussed on ... held at the Wisconsin Athletic Club. , ,Limited partners, portfolio ... in Milwaukee to hear a speech from Mark Hessen, president ... to updates from six firms that Mason Wells invests in. ...
Cached Biology Technology:Liability issues not seen as roadblock to healthcare technology advancements 2Liability issues not seen as roadblock to healthcare technology advancements 3VC trends, company progress discussed at Mason Wells portfolio meeting 2VC trends, company progress discussed at Mason Wells portfolio meeting 3VC trends, company progress discussed at Mason Wells portfolio meeting 4
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
... • Guinea Pig serum is collected from ... N-02: Citrate N-04: Heparin ... Potassium Oxalate N-10: EDTA (Na) ... N-07: CPD N-09: K3EDTA ...
Request Info...
Biology Products: