Navigation Links
New drug agent knocks out multiple enzymes in cancer pathway
Date:3/25/2009

A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells than similar drugs used in recent clinical trials.

The study appears this week in the Journal of the American Chemical Society.

The new agent belongs to a class of drugs called bisphosphonates. These compounds were originally developed to treat osteoporosis and other bone diseases, but were recently found to also have potent anti-cancer and immune boosting properties.

Drug developers have tried for years to design drugs to inhibit cell survival pathways in tumor cells, focusing on a protein called Ras since nearly a third of all human cancers involve a mutation in the Ras gene that causes cell signaling to go awry. These efforts have met with limited success.

Bisphosphonates act on other enzymes, called FPPS and GGPPS, which are upstream of Ras in the cell survival pathway. Inhibiting these enzymes appears to be a more effective strategy for killing cancer cells.

When used in combination with hormone therapy in a recent clinical trial, the bisphosphonate drug zoledronate significantly reduced the recurrence of breast cancer in premenopausal women with estrogen-receptor-positive breast cancer. Similar results were reported previously for hormone-refractory prostate cancer.

But zoledronate quickly binds to bone, reducing its efficacy in other tissues.

"We're trying to develop bisphosphonates that will be very active but won't bind to the bone, because if they bind to the bone they're not going to go to breast, lung or other tissues," said University of Illinois chemistry professor Eric Oldfield, who led the new study.

Oldfield's team also wanted to design a compound that would inhibit multiple enzymes in the tumor cell survival pathway, rather than just one, an approach analogous
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Structure of enzyme against chemical warfare agents determined
2. Chemopreventive agents in black raspberries identified
3. MIT nanotubes sniff out cancer agents in living cells
4. Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
5. Certain anticancer agents could be harmful to patients with heart disease
6. UF researchers develop improved gene therapy agent
7. New insights into the diversity of Creutzfeldt-Jakob disease agents
8. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
9. Contrast agent trials in swine
10. Agent that triggers immune response in plants is uncovered
11. Primate behavior explained by computer agents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New drug agent knocks out multiple enzymes in cancer pathway
(Date:10/17/2014)... have shown for the first time how bacteria can ... giving them the opportunity to get tremendous insights into ... study also discovered the bacterial growth in chronic lung ... slowed down by the immune cells. The researchers discovered ... "suffocate" the bacteria, forcing the bacteria to switch to ...
(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
(Date:10/15/2014)... Oct. 15, 2014 Sandata Technologies, LLC, ... and community-based care, today announced it released a ... Santrax® Electronic Visit Verification™ Solution (EVV™)  for Quality ... home health company founded in 1996 and has ... The study details the challenges ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2Sandata Announces Case Study with Quality Care Services, Inc. 2
... The Howard Hughes Medical Research Institute today announced that ... among 50 scientists nationwide to be appointed HHMI Early ... associate member of the Center,s Basic Sciences Division, and ... Center,s Human Biology and Public Health Sciences divisions, each ...
... tiny semipalmated sandpipers embark on their annual odyssey from the ... set out on one of the world,s longest migrations. On ... of Fundy on the Canadian east coast, where they spend ... which have some of the highest levels of n-3 fatty ...
... stocking has on aquatic insects in mountain lakes can ... a study completed by U.S. Forest Service and University ... current online issue of the journal Freshwater Biology where ... management practices now in use in California mountain lakes ...
Cached Biology News:Two Hutchinson Center researchers named HHMI Early Career Scientists 2Quails get super fit by simply eating omega-3 diet 2Study assesses impact of fish stocking on aquatic insects 2
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by ... Type & by Geography - Forecasts & Analysis ... vehicle market into various sub segments with an ... report also identifies the factors driving this market, ... the adoption trends. , The unmanned ground vehicle ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, [Human ... Insulin (Rapid Acting, Long Acting, Premixed)], by Brand ... Forecast to 2018” provides a detailed overview of ... trends, and strategies impacting the global human insulin ... the revenue and share analysis. , The global ...
(Date:10/18/2014)... 2014 The report "1,6-Hexanediol Market ... Forecasts to 2019", analyzes the global market on ... understand the industry details such as the key ... geographic regions. , Browse 81 Market Data Tables ... in-depth TOC on “1,6-Hexanediol Market by Application and ...
(Date:10/18/2014)... The Asia-Pacific hardware encryption display market report ... analysis and forecast of revenue. This market was valued ... $51,362.6 million by 2018, at a CAGR of 58.4% ... of the Asia-Pacific hardware encryption market report, to get ... provides a glimpse of the segmentation of the market, ...
Breaking Biology Technology:Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 51,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3
... Technologies, Inc. (NYSE Amex: PTN ) will host ... 11:00 a.m. Eastern Time to discuss its quarter ended December ... development.   Schedule for the Financial Results ... 2011 Conference Call-Live Domestic Dial-In Number , International Dial-In ...
... of Pittsburgh have been awarded funding for two projects that ... injuries to test if it is possible for them to ... prosthetic limb, with their thoughts. The projects build upon ... temporarily placed on their brains and were able to move ...
... to sharpen images of celestial bodies can now help scientists ... of a mouse. Eric Betzig, a group leader at the ... his team,s latest work using adaptive optics for biology at ... of Science in Washington, D.C. during a press conference on ...
Cached Biology Technology:New Pitt projects will test brain computer interfaces for people with spinal cord injury 2Improving microscopy by following the astronomers' guide star 2Improving microscopy by following the astronomers' guide star 3Improving microscopy by following the astronomers' guide star 4
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Rabbit polyclonal to Dishevelled 2 ( Abpromise for all tested applications). entrezGeneID: 1856 SwissProtID: O14641...
... Polyclonal Antibody to Asb-2 (Ankyrin repeat and ... raised against synthetic peptides containing amino acids ... Human spleen lysate (Imgenex Catalog No. 40149) ... It should cross react with mouse and ...
Biology Products: