Navigation Links
New discovery in living cell signaling
Date:7/3/2014

A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant to therapy. An international collaboration of researchers, led by scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley, have unlocked the secret behind the activation of the Ras family of proteins, one of the most important components of cellular signaling networks in biology and major drivers of cancers that are among the most difficult to treat.

"Ras is a family of membrane-anchored proteins whose activation is a critical step in cellular signaling, but almost everything we know about how Ras signals are activated has been derived from bulk assays, in solution or in live cells, in which information about the role of the membrane environment and anything about variation among individual molecules is lost," says Jay Groves, a chemist with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Chemistry Department. "Using a supported-membrane array platform, we were able to perform single molecule studies of Ras activation in a membrane environment and discover a surprising new mechanism though which Ras signaling is activated by Son of Sevenless (SOS) proteins."

Groves, who is also a Howard Hughes Medical Institute (HHMI) investigator, is the corresponding author of a paper in Science that reports this discovery. The paper is titled "Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics." The lead authors were Lars Iversen and Hsiung-Lin Tu, both members of Groves' research group at the time of the study. See below for a complete list of co-authors and their institutional affiliations.

The cellular signaling networks of living cells start with receptor proteins residing on a cel
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Discovery of Earths northernmost perennial spring
2. Discovery of a bud-break gene could lead to trees adapted for a changing climate
3. The transmission of information via proteins could revolutionize drug discovery
4. Scientists weed out pesky poison ivy with discovery of killer fungus
5. Amber discovery indicates Lyme disease is older than human race
6. Promising discovery in the fight against antibiotic-resistant bacteria
7. New discovery: Molecule links asthma and cancer and could aid in developing new treatments
8. Scientists at the UA make critical end-stage liver disease discovery
9. Autism Genome Project delivers genetic discovery
10. Mechanical forces driving breast cancer lead to key molecular discovery
11. New discovery finds missing hormone in birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New discovery in living cell signaling
(Date:8/28/2014)... Bethesda, MD FASEB MARC (Maximizing Access to Research ... the American Society of Human Genetics from October 18 ... awards are meant to promote the entry of students, ... mainstream of the basic science community and to encourage ... of Human Genetics. This year MARC conferred 16 ...
(Date:8/28/2014)... groups and clinicians is critical to the development ... of Georgia research. , A qualitative study of ... that role models for successful breastfeeding help positively ... "Mothers who received that support are more likely ... Alex Anderson, an associate professor in the College ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
... Organization (EMBO) and the Federation of European Biochemical ... Friedrich Miescher Institute for Biomedical Research in Basel, ... Women in Science Award. Professor Gasser has been ... stability and epigenetics and her commitment to mentoring ...
... (New York, NY) The Alfred P. Sloan ... outstanding U.S. and Canadian researchers as recipients of Sloan ... fellowships are given to early-career scientists and scholars whose ... next generation of scientific leaders. "Today,s Sloan Research ...
... DETROIT Technology to restore vision through the use ... a Wayne State University professor and scientific director of ... Eye Institute has attracted additional funding for therapy ... grant from their affiliate, National Neurovision Research Institute, to ...
Cached Biology News:Susan M. Gasser to receive the 2012 FEBS/EMBO Women in Science Award 2Sloan Research Fellowships awarded to 126 young scholars 2Wayne State-licensed technology receives grant from the Foundation Fighting Blindness 2
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... ... The Chinese Biopharmaceutical Association-USA (CBA) announced today that it ... Maryland, US. ,The event will highlight current breakthroughs, new ... develop a platform for communication and collaboration among biopharmaceutical companies, ...
... organisms on earth, carry an extra coating of protection ... latest issue of the journal Current Biology . ... the bacteria that cause botulism, tetanus, and anthrax survive ... by researchers at New York University,s Center for Genomics ...
... A team from Stevens Institute of Technology, consisting ... students: Wuming Jing, Xi Chen, and Zhenbo Fu ... and Yong Shi from the Department of Mechanical ... the IEEE/National Institute of Standards and Technology (NIST) ...
Cached Biology Technology:Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 3Biologists discover an extra layer of protection for bacterial spores 2Stevens team places third in 2010 IEEE/NIST Mobile Microrobotics Challenge 2
... The TSQ Quantum Ultra defines a new ... environmental analysis. It features the revolutionary ... a titanium skimmer with superior skimming and ... Its redesigned ion transfer tube lens ...
... to distinguish collagen from muscle in tissue ... Trichrome stain is often used to differentiate ... identify an increase in collagenous tissue. With ... stained red, collagen - blue, fibrin - ...
... of movement counts, similar to an infrared beam ... 6 subjects at once, in two frames of ... a sync pulse to coordinate with other signals ... and timing information to control arena rotations or ...
... Ultrapure ACS Reagent Grade C 19 H ... Weight: 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity ... pH 3.0 - Yellow pH ... tracking dye in agarose and acrylamide gel ...
Biology Products: