Navigation Links
New 'control knobs' for stem cells identified
Date:12/3/2008

differentiated cells compared with undifferentiated cells and that hMSCs show different membrane potential profiles during bone vs. fat differentiation.

To determine whether hyperpolarization was functionally required for differentiation, the scientists depolarized the hMSCs by exposing them either to high levels of extracellular potassium ions or to ouabain, a compound that blocks the transfer of ions in and out of cells. Both treatments disrupted the normal increase in negative voltage that occurs during differentiation and suppressed fat and bone cell differentiation markers.

In contrast, treatment with hyperpolarizing reagents up-regulated bone cell markers indicating that voltage changes are not merely permissive for differentiation but can act as an instructive signal to either induce or inhibit differentiation.

More study is needed to determine whether hyperpolarization also determines which specific type of cell stem cells will differentiate into, according to the Tufts researchers.


'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cool idea for efficient climate control wins recognition
2. A scientific breakthrough on the control of the bad cholesterol
3. Futronic Launches FS22 Fingerprint Access Control Device
4. New insight into the controls on a go-to enzyme
5. Ultrasound shown to exert remote control of brain circuits
6. Boost from McGill, Gates Foundation helps Africans control pharma research
7. Birth control has long-term effect on hormone exposure
8. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
9. Genes that control cell death fingered in age-related hearing loss
10. Can genetic information be controlled by light?
11. bioMETRX, Inc. Signs Deal To Acquire Controlling Interest in Biometric Solutions, LLC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... Ark. , Feb. 25, 2015  ABC ... and billing in the Health and Fitness Industry, ... well as to MYiCLUBonline.  The latest upgrade includes ... the inclusion of cardless check-in via Identity One ... the first time through interactive displays at the ...
(Date:2/24/2015)... This report analyzes the worldwide markets for Iris Biometrics in ... US, Canada , Japan ... , Middle East , and ... for the period 2013 through 2020. Also, a seven-year historic ... are derived from primary and secondary research. Company profiles are ...
(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ... period 2013 through 2020. Also, a seven-year historic analysis is provided ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16
... old, have been ill, or suffered an injury, you,ve watched ... slight or gradualis about as common to the human condition ... little about what causes skeletal muscles to atrophy. They know ... and parsing the key actors from the poseurs is tricky. ...
... A broken chromosome is like an unmoored beansprout circling in ... with broken chromosomes, the cell will be killed and so ... Often, it finds a workable substitute: another nearby chromosome. When ... a similar process to exchange genetic material, you,ve got a ...
... found a way to replace up to 50 per cent ... Warwick chemists have taken out much of the cocoa butter ... with tiny droplets of juice measuring under 30 microns in ... dark and white chocolate using what is known as a ...
Cached Biology News:Researchers identify key culprit causing muscle atrophy 2Researchers identify key culprit causing muscle atrophy 3Chromosomal translocations point the way toward personalized cancer care 2Chromosomal translocations point the way toward personalized cancer care 3Fruity science halves fat in chocolate 2
(Date:2/26/2015)... THOUSAND OAKS, Calif. , Feb. 26, 2015 /PRNewswire/ ... has achieved Gold Partner status in Oracle PartnerNetwork. In ... Oracle for its commitment to establish Oracle-related knowledge in ... addressing the challenges of joint customers. Originally ... allows researchers to rapidly zoom in and out of ...
(Date:2/26/2015)... SAN DIEGO , Feb. 26, 2015  Epic ... Prahalad , Ph.D. will present at the 35th Annual ... 2015 at 10:00 a.m. EST in the MIT Room, 3rd Floor. ... Copley Place Hotel in Boston, Mass. Epic is ... real-time detection of genomic and proteomic changes that occur ...
(Date:2/26/2015)...  Spark Therapeutics (NASDAQ: ONCE ) announced ... in the Cowen and Company Health Care Conference on ... the Boston Marriott Copley Place. To access ... the Cowen conference, please visit the "Upcoming Events" section ... Therapeutics website at www.sparktx.com .  A replay of ...
(Date:2/26/2015)... 2015 On Wednesday, February 25, Peggy ... nationwide Clostridium difficile (C. diff) awareness movement, lauded ... by the Centers for Disease Control & Prevention . ... a million infections among Americans in a single year, ... , The study also estimates that 29,000 patients died ...
Breaking Biology Technology:Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4Epic Sciences to Present at 35th Annual Cowen and Company Health Care Conference 2Spark Therapeutics to Participate in the 35th Annual Cowen and Company Health Care Conference 2Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 2Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 3Peggy Lillis Foundation Lauds CDC's New, More Comprehensive Study on the Burden of C. difficile Infections in the United States 4
... Monday, January 28, The Royal,Marsden Hospital (Sutton, ... Arc Therapy (VMAT)* treatment in the world ... treatment, the hospital,used its existing Elekta Synergy(R) ... system., (Logo: http://www.newscom.com/cgi-bin/prnh/20020318/ELEKTALOGO ), ...
... Caliper Life,Sciences, Inc. (Nasdaq: CALP ) ... 2008 Small and Mid Cap Growth Conference in ... at 4:40 p.m. EST. Kevin,Hrusovsky, President and CEO ... the,company,s business. The live webcast can be accessed ...
... Germany and MINNEAPOLIS, Minnesota, February 11, Bayer HealthCare ... Minneapolis, MN, (Nasdaq: POSS ), announced today ... pursuant to which,MEDRAD will acquire Possis Medical in ... or a total equity value of approximately US-Dollar ...
Cached Biology Technology:Elekta Announces First Volumetric Modulated Arc Therapy Cancer Treatment at Royal Marsden Hospital 2Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 2Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 3Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 4Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 5Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 6
Rabbit polyclonal to FANCE ( Abpromise for all tested applications). entrezGeneID: 2178 SwissProtID: Q9HB96...
Rabbit polyclonal to FANCG ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSRQTTSVGSSC, corresponding to amino acids 1 - 12 of Human FANCG. Entrez GeneID: 2189 Swis...
Rabbit polyclonal to ZNF261 ( Abpromise for all tested applications). entrezGeneID: 9203 SwissProtID: Q14202...
... CELSR3 CELSR3 is an Orphan-U GPCR ... gene is expressed during development at sites of ... in brain, spinal cord, dorsal root ganglion, and ... blood, brain, colon, heart/melanocyte/uterus, lung, nerve, and placenta ...
Biology Products: