Navigation Links
New book reviews research on p53 -- the 'guardian of the genome' -- and its relatives
Date:6/23/2010

COLD SPRING HARBOR, N.Y. (June 23, 2010) -- The p53 tumor suppressor gene, the "guardian of the genome," protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of proteins that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

A new book from Cold Spring Harbor Laboratory Press, The p53 Family, provides a comprehensive review of the functions of the p53 family. It was edited by Arnold Levine and David Lane, who independently discovered p53 about 30 years ago.

"We hope that by bringing together a unique gathering of experts this volume will provide a great introduction to the field for newcomers to the p53 family and a starting off point for vigorous debate among the converted," write Levine and Lane in the preface to the book. "The many unknowns in this system that are detailed and discussed in this volume provide us all with inspiration for future work."

In 23 chapters, the contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line.

The p53 Family also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1

Related biology news :

1. New book reviews the structure and function of cell junctions
2. EPA reviews Univ. of Michigan dioxin study
3. Reviews of microbial gene language published in special issue of Trends in Microbiology
4. Biophysical Reviews makes debut in 2009
5. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
6. Researchers create self-assembling nanodevices that move and change shape on demand
7. UCI researchers develop worlds first plastic antibodies
8. Rice yields researched to tackle food security issues
9. Freely available data supporting next generation of human genetic research
10. NYU Langone Medical Center receives $5.4 million NYSTEM grant for stem cell research
11. Research on stem cells wins first prize for Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book reviews research on p53 -- the 'guardian of the genome' -- and its relatives
(Date:2/2/2017)... JACKSONVILLE, Fla. , Feb. 2, 2017 /PRNewswire/ ... ), a clinical-stage immuno-oncology company specializing in the ... vaccines for the treatment of cancer and metastatic ... multi-gram scale-up and GMP manufacturing of a second ... T-cell vaccine targeting folate receptor alpha. The manufactured ...
(Date:2/2/2017)... , Feb. 1, 2017  Central to its ... meaningful advances worldwide, The Japan Prize Foundation today ... who have pushed the envelope in their respective ... Communication. Three scientists are being recognized with the ... that not only contribute to the advancement of ...
(Date:1/31/2017)... Jan. 31, 2017  Spero Therapeutics, LLC, a ... the treatment of bacterial infections, today announced it ... candidates from Pro Bono Bio Ltd (PBB) to ... multi-drug resistant forms of Gram-negative bacteria.   The assets ... Ltd, a PBB group company. "The ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... ... February 17, 2017 , ... Academy of Model ... world’s leading maker of unmanned aircraft systems (UAS), are launching a joint program ... drones effectively, and support educational outreach efforts. , AMA and DJI will collaborate ...
(Date:2/16/2017)... Brussels, Belgium (PRWEB) , ... February 16, 2017 , ... ... Development (SIOTAD) framework primarily aimed at the agricultural industry. Pilot studies are about to ... phytosanitary products through IoT, Big Data and 5G innovations. The concept is expected to ...
(Date:2/16/2017)... (OTCMKTS: IMMG), an early-stage biotechnology company harnessing the power of ... negative breast cancer (TNBC), announced today their completion of the ... The YEi Start in France ... business in France and Europe.  ImMAGE ... an intensive one week immersion in France ...
(Date:2/16/2017)... BEACH, Fla. , Feb. 16, 2017 /PRNewswire/ ... company revolutionizing the development of liquid biopsy tests ... has entered into an exclusive license agreement with ... distribute MDNA,s proprietary liquid biopsy test for prostate ... South Korea . This is the ...
Breaking Biology Technology: