Navigation Links
New book reviews research on p53 -- the 'guardian of the genome' -- and its relatives
Date:6/23/2010

COLD SPRING HARBOR, N.Y. (June 23, 2010) -- The p53 tumor suppressor gene, the "guardian of the genome," protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of proteins that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

A new book from Cold Spring Harbor Laboratory Press, The p53 Family, provides a comprehensive review of the functions of the p53 family. It was edited by Arnold Levine and David Lane, who independently discovered p53 about 30 years ago.

"We hope that by bringing together a unique gathering of experts this volume will provide a great introduction to the field for newcomers to the p53 family and a starting off point for vigorous debate among the converted," write Levine and Lane in the preface to the book. "The many unknowns in this system that are detailed and discussed in this volume provide us all with inspiration for future work."

In 23 chapters, the contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line.

The p53 Family also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1

Related biology news :

1. New book reviews the structure and function of cell junctions
2. EPA reviews Univ. of Michigan dioxin study
3. Reviews of microbial gene language published in special issue of Trends in Microbiology
4. Biophysical Reviews makes debut in 2009
5. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
6. Researchers create self-assembling nanodevices that move and change shape on demand
7. UCI researchers develop worlds first plastic antibodies
8. Rice yields researched to tackle food security issues
9. Freely available data supporting next generation of human genetic research
10. NYU Langone Medical Center receives $5.4 million NYSTEM grant for stem cell research
11. Research on stem cells wins first prize for Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book reviews research on p53 -- the 'guardian of the genome' -- and its relatives
(Date:7/24/2014)... by the University of York has carried out the ... Indian Ocean. , The results, reported in the ... in the management of marine protected areas, with almost ... in the region now under local community stewardship. ... seas and coasts designed to protect wildlife from damage ...
(Date:7/24/2014)... his work with a new drug that successfully treated lupus ... has received a $250,000 grant to expand his research to ... treat a wider range of autoimmune diseases., Chandra Mohan, Hugh ... at UH, previously published a study in Arthritis Research & ... treated lupus in mice and reduced the number of cases ...
(Date:7/24/2014)... release is available in German . ... to recognize and respond to threats to health, and ... detailed understanding of the mechanism underlying immunologic memory, however, ... have converged to support the hypothesis that the persistence ... cells with stem-cell-like potential. Until now, there was no ...
Breaking Biology News(10 mins):Western Indian Ocean communities play vital role in conservation 2Biomedical engineer looks at new applications for novel lupus drug 2Biomedical engineer looks at new applications for novel lupus drug 3Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3
... the biological sciences, mankind has struggled to comprehend the ... the arthropods. Now, a team of researchers, including Dr. ... History Museum of Los Angeles County (NHM), has finished ... the arthropods, answering many questions that defied previous attempts ...
... the Earth,s climate to slow or reverse global warming ... discussion. But before effective action can be taken, the ... Two Northwestern University studies, both published online recently by ... -- clues as to what drove large-scale changes to ...
... flies, has revealed a critical step in fly vision. Humans ... manifest as visual defects ranging from mild visual impairments to ... Biology paves the way for using the fruit fly ... Retinal dystrophies result from inherited defects in nearly every ...
Cached Biology News:Where did insects come from? 2Where did insects come from? 3The carbon cycle before humans 2The carbon cycle before humans 3All eyes on retinal degeneration 2
(Date:7/23/2014)... 2014  Sangamo BioSciences, Inc. (NASDAQ: SGMO ... and accomplishments. For the second quarter ... loss of $7.0 million, or $0.10 per share, compared ... per share, for the same period in 2013. As ... equivalents, marketable securities and interest receivable of $236.7 million. ...
(Date:7/23/2014)... , July 23, 2014 /PRNewswire-iReach/ -- Think Drinks are ... for the long term. They are the first functional ... sustained energy as an alternative to the temporary fix ... on Indiegogo on July 29, 2014, with hopes to ... Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... -- Having the right people at the table for significant ... and achieving clinical and operational goals. The 22 nd ... 20-22, 2014, in San Diego , ... experts discussing how partnerships have positively impacted their objectives. ... Executive Officer of Cape Regional Medical Center located in ...
(Date:7/23/2014)... MOINES, Iowa (PRWEB) July 23, 2014 ... join the business as vice president of Agricultural Biotechnology ... Mendel Biotechnology where he served most recently as president, ... extensive biotechnology and business leadership in the seed and ... Pioneer,” said Paul E. Schickler , president of ...
Breaking Biology Technology:Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3
... announces that a new market research report is ... Health of Biotechnology and Drugs Industry in India ... The research services examines the financial ... 2 broad parameters- Excellence in financial management and ...
... Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ) will ... Healthcare Conference on Monday, January 10, 2011.  The presentation ... Eastern Time).  The session may be accessed through the ... Relations page.  An archived version of the presentation will ...
... Using advanced technology to create high-quality dental lab ... mission of DentalLab.com ( http://www.dentallab.com ), a new full-service ... States and around the world. DentalLab.com was ... Holovchenko, an entrepreneur with a successful track record of ...
Cached Biology Technology:Reportlinker Adds Financial Health of Biotechnology and Drugs Industry in India and China 2Cutting-Edge Technologies Position DentalLab.com as Emerging Leader in Dental Lab Services Outsourcing 2
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... Multimode Detectors provide unmatched value and ... and automation needs. Capable of performing ... the same instrument, the DTX Series ... can be integrated seamlessly with Beckman ...
... Deparaffinization Solution is available in a ... easy-to-use reagent for dewaxing paraffin-embedded tissue ... situ hybridization, or other analytical methods. ... consists of dipping the slides in ...
... The MJ Mini thermal cycler is a compact ... x 0.2 ml tubes, 12 x 0.5 ml ... heated lid uses a thumbwheel to adjust height ... oil-free cycling. Peltier heat pumps provide excellent thermal ...
Biology Products: