Navigation Links
New and unexpected mechanism identified how the brain responds to stress
Date:3/2/2009

Calgary, AB -- Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain. Being able to quickly and successfully respond to stress is essential for survival.

Using a rat model, Jaideep Bains, PhD, a University of Calgary scientist and his team of researchers at the Hotchkiss Brain Institute have discovered that neurons in the hypothalamus, the brain's command centre for stress responses, interpret 'off' chemical signals as 'on' chemical signals when stress is perceived. "It's as if the brakes in your car are now acting to speed up the vehicle, rather than slow it down." says Bains. This unexpected finding is being published in the March 1st online edition of Nature Neuroscience.

Normally, neurons receive different chemical signals that tell them to either switch on or switch off. The off signal or brake only works if the levels of chloride ion in the cells are maintained at a low level. This is accomplished by a protein, known as KCC2. What Bains and colleagues have shown is that stress turns down the activity of KCC2, thus removing the ability of the brake, a chemical known as GABA, to work properly. A loss of the brain's ability to slow down may explain some of the harmful, emotional consequences of stress.

While the findings provide a new mechanistic explanation of how the brain interprets stress signals, "there is still much work needed in the basic science of this phenomenon before there are any new advances in the medical treatment of stress," says Bains

"This opens entirely new and quite unexpected avenues for controlling stress responses" says Yves De Koninck, PhD, president-elect of the Canadian Association for Neuroscience and professor of Psychiatry at Laval University.

"I was fascinated when I learned of this work. It has not been clear till now how the neuroendocrine stress response was activated by external stressors. Bains' work shows a complex, yet elegant solution, involving a switch from inhibition to excitation." says Jane Stewart, PhD a behavioural neuroscientist from Concordia University, "these findings may lead to a better understanding of the changes in sensitivity to stress that result from chronic exposure."


'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Related biology news :

1. Coral reef fish harbor an unexpectedly high biodiversity of parasites
2. Amazon forest shows unexpected resiliency during drought
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Quakes under Pacific floor reveal unexpected circulatory system
5. Researchers explore altruisms unexpected ally -- selfishness
6. Plant biologists discover unexpected proteins affecting small RNAs
7. UT Knoxville professor finds unexpected key to flowering plants diversity
8. Unexpected large monkey population discovered
9. Study of placenta unexpectedly leads to cancer gene
10. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
11. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/14/2016)... 14, 2016 http://www.apimages.com ) ... --> - Renvoi : image disponible via AP ... --> --> DERMALOG, le leader ... nouveaux lecteurs d,empreintes digitales pour l,enregistrement des réfugiés ... utilisé pour produire des cartes d,identité aux réfugiés. ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... ... to announce the appointment of John Tilton as Chief Commercial Officer.  Mr. Tilton ... one of the founding commercial leaders responsible for the commercialization of multiple orphan ...
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group and ... Symposium as other research and development initiatives for potential stem cell protocol management for ... Stem Cells Group executives began meeting to establish a working agenda and foster initiatives ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office ... as one of three finalists for the European Inventor Award 2016 in the category ... will be announced at a ceremony in Lisbon on June 9th. , The human ...
(Date:4/26/2016)... ... 26, 2016 , ... Seattle based non-profit, The Institute for ... Corporation. The grant will be used to further the scientific research goals of ... http://www.ivsci.org , In accounting the grant to the IVS, Mr. Glenn ...
Breaking Biology Technology: