Navigation Links
New and unexpected mechanism identified how the brain responds to stress
Date:3/2/2009

Calgary, AB -- Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain. Being able to quickly and successfully respond to stress is essential for survival.

Using a rat model, Jaideep Bains, PhD, a University of Calgary scientist and his team of researchers at the Hotchkiss Brain Institute have discovered that neurons in the hypothalamus, the brain's command centre for stress responses, interpret 'off' chemical signals as 'on' chemical signals when stress is perceived. "It's as if the brakes in your car are now acting to speed up the vehicle, rather than slow it down." says Bains. This unexpected finding is being published in the March 1st online edition of Nature Neuroscience.

Normally, neurons receive different chemical signals that tell them to either switch on or switch off. The off signal or brake only works if the levels of chloride ion in the cells are maintained at a low level. This is accomplished by a protein, known as KCC2. What Bains and colleagues have shown is that stress turns down the activity of KCC2, thus removing the ability of the brake, a chemical known as GABA, to work properly. A loss of the brain's ability to slow down may explain some of the harmful, emotional consequences of stress.

While the findings provide a new mechanistic explanation of how the brain interprets stress signals, "there is still much work needed in the basic science of this phenomenon before there are any new advances in the medical treatment of stress," says Bains

"This opens entirely new and quite unexpected avenues for controlling stress responses" says Yves De Koninck, PhD, president-elect of the Canadian Association for Neuroscience and professor of Psychiatry at Laval University.

"I was fascinated when I learned of this work. It has not been clear till now
'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coral reef fish harbor an unexpectedly high biodiversity of parasites
2. Amazon forest shows unexpected resiliency during drought
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Quakes under Pacific floor reveal unexpected circulatory system
5. Researchers explore altruisms unexpected ally -- selfishness
6. Plant biologists discover unexpected proteins affecting small RNAs
7. UT Knoxville professor finds unexpected key to flowering plants diversity
8. Unexpected large monkey population discovered
9. Study of placenta unexpectedly leads to cancer gene
10. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
11. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... baby a gift of germsgerms that help to ... to fend off infection, may paradoxically interrupt a ... more susceptible to dangerous pathogens. , A ... Children,s Hospital of Philadelphia (CHOP) sheds light on ... play a crucial role in fostering the rapid ...
(Date:4/20/2014)... crop residue to make ethanol and other biofuels reduces ... gasoline, according to a study published today in the ... by a University of Nebraska-Lincoln team of researchers cast ... meet federal mandates to ramp up ethanol production and ... stalks, leaves and cobs in cornfields after harvest -- ...
(Date:4/18/2014)... crystallography and nuclear magnetic resonance imaging (NMR) to gain ... such efforts have long been hampered by the fact ... and often in ordered and crystalized form to be ... into the structure of most molecules. , Harvard researchers, ... of the past. , A team of scientists, ...
Breaking Biology News(10 mins):Study of gut microbes, antibiotics: Clues to improving immunity in premature infants 2Study casts doubt on climate benefit of biofuels from corn residue 2Study casts doubt on climate benefit of biofuels from corn residue 3MRI, on a molecular scale 2MRI, on a molecular scale 3
... a new biosensor microchip that could significantly speed ... packed with highly sensitive "nanosensors," analyze how proteins ... evaluating the effectiveness and possible side effects of ... of the nanosensors can simultaneously and continuously monitor ...
... This release is available in Spanish . ... safety hazard if they are harvested from waters polluted with ... studying ways to enhance the food safety of these popular ... at Delaware State University in Dover is exploring new techniques ...
... EAST LANSING, Mich. Despite the growing scientific ... become increasingly polarized on the environmental problem, according ... State University researcher. The gap between Democrats ... increased 30 percent between 2001 and 2010 ...
Cached Biology News:New biosensor microchip could speed up drug development, Stanford researchers say 2New biosensor microchip could speed up drug development, Stanford researchers say 3Keeping oysters, clams and mussels safe to eat 2Democrats and Republicans increasingly divided over global warming 2Democrats and Republicans increasingly divided over global warming 3
(Date:1/15/2014)... Freeslate, Inc ., the leading provider ... Limited, one of India’s top five pharmaceutical companies, has ... for high throughput solid form screening. , ... wide range of quality, affordable generic and branded formulations ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an ... products to serve the wound care market. , Free ... Alliqua was restructured with a seasoned management team and ...
(Date:1/14/2014)... Toronto, Canada (PRWEB) January 14, 2014 ... and its motives and methods in product development and ... of the industry. This mistrust, fueled by concerns about ... further fed by reports of spectacular fines to the ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... National Science Foundation (NSF) has selected a University of ... of NSF Innovation Corps awards. The I-Corps Awards recognize ... connects scientists to entrepreneurial resources. "The idea is ... property from the lab into the commercial world," said ...
... Nanoparticles of a substance can be counted and the size ... gas. But some nanoparticles tend to aggregate when the surrounding ... shown that it is possible to sort and count the ... are already used in many everyday products, such as sunscreen ...
... Mich., Oct. 11, 2011 New England Biolabs, Inc. ... signed a distribution agreement whereby NEB will distribute a ... the amplification of DNA from single cells or extremely ... Genome Amplification (WGA) Kit is the first product available ...
Cached Biology Technology:Penn team wins entrepreneurial innovation award 2How to count nanoparticles 2New England Biolabs and Rubicon Genomics Enter into Distribution Agreement for Single Cell Amplification Products 2
... is based on quantification of the green ... free orthophosphate. The rapid color formation from ... a spectrophotometer (600-660 nm) or on a ... have been optimized to offer superior sensitivity ...
... analysis standard is a lyophilized mixture ... alcohol; molecular weights range from 152 ... for use with the Aminex HPX-87C ... for column testing or semiquantitative determination. ...
Metamine is an autonomous data mining tool that extends the capabilities of conventional research teams. It is a proactive agent that searches for significant results buried within the GeNet data rep...
... Equine EIA Principle: ... and LTE4 are products of ... and glutathione-S-transferase. In the past, ... Reacting Substances of Anaphylaxis (SRS-A)". ...
Biology Products: