Navigation Links
New and unexpected mechanism identified how the brain responds to stress
Date:3/2/2009

Calgary, AB -- Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain. Being able to quickly and successfully respond to stress is essential for survival.

Using a rat model, Jaideep Bains, PhD, a University of Calgary scientist and his team of researchers at the Hotchkiss Brain Institute have discovered that neurons in the hypothalamus, the brain's command centre for stress responses, interpret 'off' chemical signals as 'on' chemical signals when stress is perceived. "It's as if the brakes in your car are now acting to speed up the vehicle, rather than slow it down." says Bains. This unexpected finding is being published in the March 1st online edition of Nature Neuroscience.

Normally, neurons receive different chemical signals that tell them to either switch on or switch off. The off signal or brake only works if the levels of chloride ion in the cells are maintained at a low level. This is accomplished by a protein, known as KCC2. What Bains and colleagues have shown is that stress turns down the activity of KCC2, thus removing the ability of the brake, a chemical known as GABA, to work properly. A loss of the brain's ability to slow down may explain some of the harmful, emotional consequences of stress.

While the findings provide a new mechanistic explanation of how the brain interprets stress signals, "there is still much work needed in the basic science of this phenomenon before there are any new advances in the medical treatment of stress," says Bains

"This opens entirely new and quite unexpected avenues for controlling stress responses" says Yves De Koninck, PhD, president-elect of the Canadian Association for Neuroscience and professor of Psychiatry at Laval University.

"I was fascinated when I learned of this work. It has not been clear till now
'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coral reef fish harbor an unexpectedly high biodiversity of parasites
2. Amazon forest shows unexpected resiliency during drought
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Quakes under Pacific floor reveal unexpected circulatory system
5. Researchers explore altruisms unexpected ally -- selfishness
6. Plant biologists discover unexpected proteins affecting small RNAs
7. UT Knoxville professor finds unexpected key to flowering plants diversity
8. Unexpected large monkey population discovered
9. Study of placenta unexpectedly leads to cancer gene
10. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
11. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... State University researcher found that bacteria in the Gulf ... the oil released during the Deepwater Horizon spill in ... toxic contaminants. , In two new studies conducted in ... a species of bacteria called Colwellia likely ... xylene compounds that were released as part of the ...
(Date:7/31/2014)... 2014 NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication ... investors and consumers wanting to learn more about ... be on-air today, July 31 st . ... be featured in a segment of NewsWatch, a ... on the History Channel, FYI Network today. ...
(Date:7/30/2014)... the way for a breakthrough that may prevent ... to poisonous chemicalsparticularly those in pesticides and chemical ... issue of the journal ChemBioChem outlines ... commonly used in pesticides and warfare agents. The ... Engineering Associate Professor of Chemical and Biological Engineering ...
Breaking Biology News(10 mins):NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3Engineering a protein to prevent brain damage from toxic agents 2
... ARBORWorking beneath the towering oaks and maples on the ... their faculty adviser helped explain an observation that had ... caterpillars. The caterpillars, which defoliate and sometimes kill ... Northeast, are especially fond of oaks, but sugar maple ...
... Escocia, 30 de enero de 2013 Life ... anunció que proveerá una solución de laboratorio íntegra para ... comunes en Libia a raíz de la insurrección de ... durante el régimen de 42 años de Muammar Gaddafi. Se ...
... U.S. Antarctic Program (USAP) and Antarctica New Zealand have jointly ... Antarctic aircraft crash after examination of the plane indicated that ... the wreckage that is largely embedded in snow and ice ... able to recover some equipment from the exposed tail of ...
Cached Biology News:Campus as laboratory: U-M student biologists use Diag trees to help solve gypsy moth mystery 2Campus as laboratory: U-M student biologists use Diag trees to help solve gypsy moth mystery 3Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 2Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 3Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 4US, New Zealand search-and-rescue teams recalled from Antarctic plane crash site 2
(Date:7/31/2014)... Calif. , July 31, 2014 Rogne ... San Francisco Bay Area , has acquired a ... of Oxford,s commercialisation company. The potent anti-inflammatory activity of ... at the University of Oxford,s Sir William ... company, which has raised over $1.5 million in seed ...
(Date:7/31/2014)... July 31, 2014 Research and Markets ... Genomics Market 2014-2018" report to their offering. ... is the study of the genetic material or genomes ... strong basis for the discovery and development of diagnostic ... or health conditions. Genomics is supported by three major ...
(Date:7/31/2014)... China , July 31, 2014 ... Irys™System by BGI , the world,s ... comprehensive exploration of human structural variation (SV) and to ... including those where no reference exists. In addition, BioNano ... for multiplexing on the Irys System, enabling significantly higher ...
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
Breaking Biology Technology:Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... Stephen Simes, chief executive,officer of BioSante Pharmaceuticals, ... be featured in an exclusive interview with, http://www.wallst.net ... EDT. The interview,will be posted on http://www.wallst.net ... The interview will cover topics including BioSante,s ...
... MONTEREY, Calif., Sept. 24 Today, the ... that utilize PARI,s,eFlow electronic nebulizer for aerosol ... acquisition of Corus Pharma in,August 2006, this ... a,licensed eFlow is featured prominently in the ...
... WEST BRIDGEWATER, Mass., Sept. 24 Pressure,BioSciences, Inc. ... update on,various corporate activities, including the expansion of ... stock on the Frankfurt Stock Exchange, and,reaffirmation of ... Barocycler instruments. 1) Domestic Sales Force: the ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Pediatric Asthma Programs Featuring PARI Pharma's eFlow Acquired by AstraZeneca 2Pressure BioSciences, Inc. Provides Corporate Update 2Pressure BioSciences, Inc. Provides Corporate Update 3
Anti-Digoxigenin-AP, Fab fragments; from sheep...
...
... Immunogen: Partially purified chicken ... detects vitamin D receptor (VDR) from ... and fish tissues. This antibody ... glucocorticoid receptors. MA1-710 detects both ...
... AccuPrime™ Pfx DNA Polymerase is ideal ... for downstream applications such as cloning ... provided by a proprietary enzyme preparation ... sp. with proofreading (3'Cut Site5' exonuclease) ...
Biology Products: