Navigation Links
New advances in the management of patients with cirrhosis
Date:4/24/2013

Amsterdam, The Netherlands, Thursday 25 April 2013: New data from clinical studies presented for the first time at the International Liver Congress 2013 provide new rationale for an old and established treatment option for portal hypertension. Additionally, spleen stiffness predicts the occurrence of clinical complications, which is of paramount importance in clinical practice.

In patients with cirrhosis, increasing blood pressure in the abdominal circulatory system (known as portal hypertension) leads to potentially lethal complications which might be prevented with simple medical treatment. Patients with cirrhosis and portal hypertension have increased gastrointestinal permeability which allows the movement of bacteria or bacterial components through the lining of the gut into the blood stream in a process known as bacterial translocation. Bacterial components such as lipopolysaccharide can be involved in the genesis of complications of cirrhosis.

The first study evaluated the effects of a non-selective beta-blocker (NSBB) on gastrointestinal permeability and bacterial translocation in patients with cirrhosis with high levels of portal hypertension.1 Patients with severe portal hypertension (HVPG* ≥20mmHg) had increased markers of gastrointestinal permeability and bacterial translocation compared to patients with lower levels of portal hypertension (HVPG<20mmHg). Treatment with NSBB significantly reduced HVPG, improved gastrointestinal permeability and decreased bacterial translocation (LPS-binding protein (LBP) -16% p=0.018; IL-6 -41% p< 0.0001) levels.

Patients who were found to have the highest levels of gastrointestinal permeability were also found to be at most risk of bleeding from oesophageal varices; a complication of cirrhosis which carries a high risk of mortality.

These findings provide a new rationale for the use of non-selective beta-blockers in patients with cirrhosis. EASL's Treasurer Prof. Mauro Be
'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-790-013-8904
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Advances in personalized medicine for lung cancer
2. 5th Annual Advances in Biomolecular Engineering Symposium
3. March of Dimes awards $250,000 prize to 2 scientists who pioneered advances in skin disorders
4. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
5. Computing advances vital to sustainability efforts; new report recommends problem-focused, iterative approach to research
6. Major advances in understanding the regulation and organization of the human genome
7. Geologist calls for advances in restoration sedimentology
8. Study advances use of stem cells in personalized medicine
9. Discovery of 100 million-year-old regions of DNA shows short cut to crop science advances
10. IOF Asia-Pacific Meeting presents new research and advances in osteoporosis management
11. Discovery of first motor with revolution motion in a virus-killing bacteria advances nanotechnology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... DUBLIN , May 20, 2015 ... Markets ( http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the ... of the Global Iris Recognition Market" ... http://photos.prnewswire.com/prnh/20130307/600769) , ,This research service analyses ... across the government and commercial sectors, ...
(Date:5/19/2015)... DUBLIN , May 19, 2015 /PRNewswire/ ... ) has announced the addition of the  ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A ... provides an in-depth analysis of the current ... introduction of gene-based tests, their working principles ...
(Date:5/11/2015)... JOSE, Calif. , May 11, 2015 /PRNewswire/ ... developer of human interface solutions, today announced the ... Vice President and Chief Financial Officer, reporting to ... Ali replaces Synaptics, current Chief Financial Officer, ... December 2014. Mr. Ali brings ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Global Genetic Testing Market Outlook 2018 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... molecular fingerprints of what your cells are up to and ... cancer. You,ve likely heard about metabolites; your physician probably ... at your annual physical. Scientists suspect we have about 3,000 ... different compounds in our bodies. Dr. Sreekumar, ...
... 2009 A review by researchers at Northwestern University ... of the utility of probiotics in the treatment of ... 35624 was the only probiotic strain out of ... improve symptoms of IBS, including abdominal pain, bloating and ...
... at your desk and suddenly your heart is beating ... on fumes. It is a shocking, uncomfortable and frightening ... cause of sudden cardiac death or SCD, a condition ... States. Scientists are now closer to understanding what causes ...
Cached Biology News:Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment 2Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment 3Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment 4Review of probiotic trial research finds only Bifantis able to claim efficacy for IBS symptoms 2Ten genes identified in connection with sudden cardiac death 2
(Date:5/29/2015)... IRVING, Texas , May 29, 2015 /PRNewswire/ ... company focused on fulfilling the promise of precision ... five studies that demonstrate the clinical utility of ... comprehensive tumor profiling service, in helping to identify ... aggressive tumors. In each of the studies, results ...
(Date:5/29/2015)... May 29, 2015 Translation is frequently listed ... for a good reason--if used in a way that is ... offering of a business product or service offering. , ... have a positive effect on a company's bottom line: , ... anyone in the world can use, why not offer it ...
(Date:5/28/2015)... , May 27, 2015 Research ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing use ... industries is anticipated. Nanotechnology will be applied ... from formulations for optimal delivery to diagnostic ...
(Date:5/28/2015)... LAWRENCEVILLE, N.J. , May 28, 2015 ... announced that it has received commitments from two institutional ... million of the Company,s common stock in an at-the-market ... warrants to purchase common stock. The Company ... pursuant to which the Company agreed to sell an ...
Breaking Biology Technology:Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6Three Ways Translation Can Help Businesses Grow 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 3
... In my last column, I reviewed some of the key ... experiences of 25 of the largest practitioners of outsourcing in ... another study conducted by the consulting firm DiamondCluster of over ... report can be downloaded here . ...
... Interest in UW-Madison's RFID Lab is so strong that ... after all of the 120 spots available for the tour were ... is canceling" to make room for those on the list, said ... "It shows that people are really excited about RFID." , ,Visitors ...
... eagerly await responses from the FDA to requests ... submissions for premarket clearance of medical devices, and ... of FDA letter -- a warning letter -- ... written notice that the FDA has identified significant ...
Cached Biology Technology:Is outsourcing reaching its limits or simply pausing for breath? - Part II 2Is outsourcing reaching its limits or simply pausing for breath? - Part II 3Is outsourcing reaching its limits or simply pausing for breath? - Part II 4It's in the mail -- Responding to an FDA warning letter 2It's in the mail -- Responding to an FDA warning letter 3It's in the mail -- Responding to an FDA warning letter 4
... System is intended for use in the ... an in-house validated in vitro nucleic acid ... • The CHEMICON ... capture assay designed to detect amplified nucleic ...
... these culture chambers produce cell yields in ... range and are useful alternatives to multiple ... mechanical • strength and structural integrity • ... Certified nonpyrogenic and sterilized by gamma irradiation, ...
BD BioCoat Collagen IV 150 mm Culture Dishes...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
Biology Products: