Navigation Links
New advances in the management of patients with cirrhosis
Date:4/24/2013

Amsterdam, The Netherlands, Thursday 25 April 2013: New data from clinical studies presented for the first time at the International Liver Congress 2013 provide new rationale for an old and established treatment option for portal hypertension. Additionally, spleen stiffness predicts the occurrence of clinical complications, which is of paramount importance in clinical practice.

In patients with cirrhosis, increasing blood pressure in the abdominal circulatory system (known as portal hypertension) leads to potentially lethal complications which might be prevented with simple medical treatment. Patients with cirrhosis and portal hypertension have increased gastrointestinal permeability which allows the movement of bacteria or bacterial components through the lining of the gut into the blood stream in a process known as bacterial translocation. Bacterial components such as lipopolysaccharide can be involved in the genesis of complications of cirrhosis.

The first study evaluated the effects of a non-selective beta-blocker (NSBB) on gastrointestinal permeability and bacterial translocation in patients with cirrhosis with high levels of portal hypertension.1 Patients with severe portal hypertension (HVPG* ≥20mmHg) had increased markers of gastrointestinal permeability and bacterial translocation compared to patients with lower levels of portal hypertension (HVPG<20mmHg). Treatment with NSBB significantly reduced HVPG, improved gastrointestinal permeability and decreased bacterial translocation (LPS-binding protein (LBP) -16% p=0.018; IL-6 -41% p< 0.0001) levels.

Patients who were found to have the highest levels of gastrointestinal permeability were also found to be at most risk of bleeding from oesophageal varices; a complication of cirrhosis which carries a high risk of mortality.

These findings provide a new rationale for the use of non-selective beta-blockers in patients with cirrhosis. EASL's Treasurer Prof. Mauro Be
'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-790-013-8904
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Advances in personalized medicine for lung cancer
2. 5th Annual Advances in Biomolecular Engineering Symposium
3. March of Dimes awards $250,000 prize to 2 scientists who pioneered advances in skin disorders
4. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
5. Computing advances vital to sustainability efforts; new report recommends problem-focused, iterative approach to research
6. Major advances in understanding the regulation and organization of the human genome
7. Geologist calls for advances in restoration sedimentology
8. Study advances use of stem cells in personalized medicine
9. Discovery of 100 million-year-old regions of DNA shows short cut to crop science advances
10. IOF Asia-Pacific Meeting presents new research and advances in osteoporosis management
11. Discovery of first motor with revolution motion in a virus-killing bacteria advances nanotechnology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... genus of planthopper known as Conosimus, which now includes ... in the southern part of the Iberian Peninsula in ... appears in the open-access Journal of Insect Science ... Conosimus baenai , has been named after Manuel ... taxonomy of Iberian Hemiptera. , Conosimus baenai ...
(Date:7/21/2014)... Jocelyn Millar , a professor of entomology ... of Chemistry at the University of California, Riverside, ... by the International Society of Chemical Ecology ( ISCE ... Silver Medal is the society,s highest honor. It ... contributions to chemical ecology, the study of chemicals that ...
(Date:7/21/2014)... tracking to monitor seals, every movement, researchers have shown ... drawn to offshore wind farms and pipelines. Those man-made ... grounds, according to a study published in the Cell ... , "I was shocked when I first saw ... Sheringham Shoal," an offshore wind farm in the United ...
Breaking Biology News(10 mins):UC Riverside entomologist receives international honor for chemical ecology contributions 2Seals forage at offshore wind farms 2
... years of research over five degraded landscapes in the National Park ... that field mice base their diet on holm oak and pine ... scrubland in the forests. The trees in the ... predators which are impeding their expansion over the mountains. In 98.5% ...
... A University of Leicester-led study may have uncovered the ... older people with high blood pressure, when compared to other ... by Bryan Williams, Professor of Medicine at the University of ... in the prestigious Journal of the American College of ...
... A new policy paper by Rice University,s Baker ... the size and influence of noncommercial traders, or "speculators," ... by the Commodities Futures Modernization Act of 2000. Speculators ... positions in the U.S. oil futures market, compared with ...
Cached Biology News:Small rodents encourage the formation of scrubland in Spain 2Beta-blockers and stroke -- new insights into their use for older people 2Study: Oil speculators dominate open interest in oil futures 2Study: Oil speculators dominate open interest in oil futures 3
(Date:7/22/2014)... og SHENZHEN , Kina, ... Co., LTD, (BGI Tech), et datterselskab af BGI, ... en ny human whole exome-sekvenseringstjeneste baseret på Complete ... højt anset i branchen for at levere patenterede ... af alle typer varianter, blev købt af BGI ...
(Date:7/22/2014)... , July 22, 2014 Hussey Copper ... MD-Cu 29 antimicrobial copper announces Pullman Regional Hospital,s ... first EPA-registered antimicrobial solid touch surface, at a nominal ... of MRSA, E-coli and other bacteria within 2 hours of ... protecting against bacteria and infectious diseases in its facilities. ...
(Date:7/22/2014)... Quorum Review IRB, the industry leader in central ... called Quick Step™ . The offering went live on ... industry’s need for seamless study start-up with a large volume ... planning 50 or more North American investigator sites, as well ... count of 80 or more. Qualifying studies may also enroll ...
(Date:7/22/2014)... Biofeedback – When a behavioral problem ... medication to best treat it can become a matter ... electroencephalography (EEG) can help predict which medicine will offer ... adverse drug events. , The article “Medication Prediction ... issue of the journal Biofeedback offers evidence that quantitative ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3
... , SHANDONG , ... YCT,International Group, Inc. ("China YCT" or the "Company") (OTC Bulletin ... the State Intellectual,Property Office of the People,s Republic of ... Spring Pharmaceutical Co.,Ltd., for "a unique method of making ginkgo ...
... soon be sporting RFID tags to improve their safety. ... Ontario Centres of Excellence (OCE) are undertaking a $1.4 ... can be used to notify subway vehicles of the ... "Our customers have asked us if we could ...
... ... University,s R&D Facility , ... Boston, MA (Vocus) January 21, 2010 -- The University of Massachusetts Boston today ... sample preparation instruments, has moved its research and development operations to the university,s ...
Cached Biology Technology:China YCT International Group, Inc. Announces That the State Intellectual Property Office of the People's Republic of China has Approved a Patent to its Operating Subsidiary, Shandong Spring Pharmaceutical Co. Ltd. 2China YCT International Group, Inc. Announces That the State Intellectual Property Office of the People's Republic of China has Approved a Patent to its Operating Subsidiary, Shandong Spring Pharmaceutical Co. Ltd. 3RFID tags to boost transit worker safety 2UMass Boston's Venture Development Center Announces New Bio-Science Partner 2UMass Boston's Venture Development Center Announces New Bio-Science Partner 3
The product contains 2 ml Dynabeads® Epoxy (4.5 μm). Supplied at 4 x 10e8 beads/ml...
... to Endothelin B Receptor Like Protein ... Protein 2 (ETBR-LP-2) has been reported ... isolated from human brain and colon ... peptide (unfortunately, the amino acid sequence ...
... recognized by A300-183A maps to ... of human quaking homolog according ... The epitope is not ... 3, 4, 6, 7 or ...
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
Biology Products: