Navigation Links
New RNA-based therapeutic strategies for controlling gene expression
Date:2/2/2012

New Rochelle, NY, February 2, 2012Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes, and researchers have discovered new mechanisms by which RNA drugs can control gene activity. A comprehensive review article in Nucleic Acid Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc., details these advances.

Short strands of nucleic acids, called small RNAs, can be used for targeted gene silencing, making them attractive drug candidates. These small RNAs block gene expression through multiple RNA interference (RNAi) pathways, including two newly discovered pathways in which small RNAs bind to Argonaute proteins or other forms of RNA present in the cell nucleus, such as long non-coding RNAs and pre-mRNA.

Keith T. Gagnon, PhD, and David R. Corey, PhD, University of Texas Southwestern Medical Center, in Dallas, review common features shared by RNAi pathways for controlling gene expression and focus in detail on the potential for Argonaute-RNA complexes in gene regulation and other exciting new options for targeting emerging forms of non-coding RNAs and pre-mRNAs in the article "Argonaute and the Nuclear RNAs: New Pathways for RNA Mediated Control of Gene Expression."

"The field of RNA mediated control of gene expression is rapidly evolving and the article by Gagnon and Corey provides a highly informative and up to date review of this exciting and often surprising area of biomedical research. We are delighted to publish this important review for the field," says Co-Editor-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC.


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related biology news :

1. Cell Therapeutics, Inc. Expects That the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February
2. New smart nanotherapeutics can deliver drugs directly to the pancreas
3. ISG15: A novel therapeutic target to slow breast cancer cell motility
4. Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference
5. New potential therapeutic target identified for Diffuse Large B-Cell Lymphoma
6. Discovery of therapeutic peptides affecting mitochondria
7. Lung stem cells offer therapeutic clues
8. Xencor Initiates Phase 1 Study of XmAb®5871 Therapeutic Antibody for the Treatment of Autoimmune Diseases
9. CHEO scientist advances biotherapeutics as published in Cancer Cell
10. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
11. Novel drug combination offers therapeutic promise for hard-to-treat cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New RNA-based therapeutic strategies for controlling gene expression
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
(Date:6/18/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market announces that its Wocket® smart wallet will be the ... scheduled to air on WABC Radio (am770) in ... The broadcast air- time for the extensive one ... Inc.,s CEO Gino Pereira will be discussing its ...
(Date:6/17/2015)... Germany , June 17, 2015 ... QIA) today launched new Investigator ® STR assay kits ... the United States . The new genetic fingerprint ... genomic markers (short tandem repeats or STRs) for DNA matching. ... the quality of DNA in each sample, a novel QIAGEN ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... an important role in various addictions, such as alcoholism ... is due, in part, to genetic factors, reveals new ... is a neuropeptide that both activates the brain,s reward ... are hungry, levels of ghrelin increase, activating the brain,s ...
... Alberta-led research team has determined that the mountain pine beetle ... possibility for an infestation that could stretch across the Prairies ... of U of A tree biologists and geneticists discovered that, ... Columbia, it successfully jumped species from its main host, the ...
... in the United States in late 2004, many producers feared ... of the world. In response to this threat, researchers have ... fungus, and a recent report in Crop Science ... to determine which of the soybean germplasm accessions were resistant ...
Cached Biology News:Genetic changes behind sweet tooth 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 3
(Date:6/30/2015)... YORK , June 30, 2015  The Dr. Samadi ... is now offering a full suite of new genetic ... had a biopsy, for diagnosing prostate cancer. ... range of genetic tests for assessing the risk and optimizing ... "We,re very excited to now offer these revolutionary ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys today announced a ... archwire that allows orthodontists to simultaneously apply different forces to different teeth. The ... “We’re thrilled about taking SmartArch one step closer to commercial availability for orthodontists ...
(Date:6/29/2015)... ... June 30, 2015 , ... This cutting edge standard making is a ... 12 distinct peaks, the WAV-8 is the world’s first cuvette-shaped, solid-state filter that lets ... the NIR range. Previous spectrophotometer calibration standards, such as those made from didymium glass ...
(Date:6/29/2015)... Lexington, KY and Manhattan, KS (PRWEB) , ... ... ... it has acquired US PATENT 7736892 B2. Under the terms of the agreement, ... using Umbilical Cord Matrix Stem Cells (UCMSCs). MB-007 is currently in pre-clinical development ...
Breaking Biology Technology:New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3
... with Pfizer,s recently ... MALIBU, Calif., Nov. 15 Pathway Diagnostics announces,that the ... Patent,number 7,294,458 (the ,458 patent) entitled "Analysis of HIV-1 ... Diagnostics,has licensed the ,458 patent (with rights to sub-license) ...
... At a meeting of the,Board of ... ), held today, a dividend of ... outstanding shares of Preferred Stock was,declared ... stockholders of record at the close,of ...
... George Abercrombie, Pfizer R&D Head Martin,Mackay, HHS Deputy Secretary ... Headline Agenda at FDA/CMS Summit 2007, WASHINGTON, Nov. ... for drug approvals. Unfortunately for the biopharma sector and,investors, ... is on track,to grant marketing approval to 18 or ...
Cached Biology Technology:Pathway Diagnostics Announces Patent Issuance for the Diagnostic Measurement of HIV Tropism for the Initiation or Modification of HIV Therapy 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 3