Navigation Links
New NIST web tool makes working with glycan sugars a lot sweeter
Date:7/11/2014

When researchers at the National Institute of Standards and Technology (NIST) need a special tool to do their work more effectively, they often prove that necessity is truly the mother of invention. Such was the case recently for M. Lorna De Leoz and Stephen Stein, NIST chemists working in the growing specialization of glycomics. Glycomics is the study of the abundant, often-branched sugar chains called glycans that are attached to proteins and lipids and influence cellular processes, including immunity, protein folding and, sometimes, changes associated with cancer.

Like their fellow scientists in the glycomics field, De Leoz and Stein rely heavily on mass spectral (MS) analyses that yield "chemical fingerprints" used to characterize the mass, composition and organization of individual glycan molecules. The human body produces thousands of different glycans and, unfortunately, MS analysis is slow and laborious, involving lots of number crunching by hand. Out of their frustration with this low-tech system for calculating high-tech MS data, the NIST duo came up with a tool that automates most of the process.

Their new Glyco MS Calculator automatically determines the mass of individual glycan components and breaks them down element-by-element. Designed in a spreadsheet format, the user inputs the number of residues (the individual units that make up a polymer; in this case, the monosaccharide sugars in the polysaccharide chain) in the glycan and the program calculates the masses and elemental composition within the molecule. It also provides mass and composition for glycans that are chemically modified. Finally, the calculator generates the mass of molecules formed as byproducts of mass spectrometry so that they can be considered when interpreting the MS data.


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1

Related biology news :

1. UH chemical engineer makes device fabrication easier, thanks to NSF grant
2. #Sexychem: 4 ways chemistry makes sex safe -- and spicy (video)
3. New, fossil-fuel-free process makes biodiesel sustainable
4. Researchers test whether Red Queen hypothesis makes species resilient
5. GaitTrack app makes cellphone a medical monitor for heart and lung patients
6. Novel antioxidant makes old arteries seem young again, CU-Boulder study finds
7. Simply being called fat makes young girls more likely to become obese
8. How vision makes sure that little fish do not get carried away
9. Sport makes muscles and nerves fit
10. New stratigraphic research makes Little Foot the oldest complete Australopithecus
11. What makes flying snakes such gifted gliders?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New NIST web tool makes working with glycan sugars a lot sweeter
(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying to ... and potential for genomic science as a means to ... prevention and treatment.  I was honored to participate in ... precision medicine program. Since the 1980s ... of genomics—from the first sequenced genome of a free ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ... A Global Market Overview" report to their offering. ... to ensure that an individual is who she/he is claiming ... use of a person,s unique physical characteristics, such as fingerprint, ...
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading ... the launch of its new website design. "When ... its infancy", says Peter O,Neill , founder and CEO ... the industry needs involvement from the key players on a ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2
... in the Journal of Food Science , scientists from ... over 85% of the cocoa flavanols were preserved in recipes ... chocolate cakes, antioxidant activity and cocoa flavanols could be largely ... soda. The scientists initially saw that 50 to ...
... Marine Sanctuary is among the healthiest coral reef ecosystems ... to a new NOAA report. The report, A ... within the Flower Garden Banks National Marine Sanctuary, offers ... sanctuary based on data collected in 2006 and 2007. ...
... , , , , , ... AUDIO: Listen to the sound of a single prawn feeding. , ... , , , , , , ... , , , , , What sound does a prawn make when it eats? How much food can one prawn devour in a ...
Cached Biology News:New study shows that cocoa flavanols can be preserved during cooking and baking 2NOAA report finds flower garden banks sanctuary reefs among healthiest in Gulf 2Dissecting the dining habits of prawns 2Dissecting the dining habits of prawns 3Dissecting the dining habits of prawns 4
(Date:2/27/2015)... 27, 2015 Cytokinetics, Incorporated (Nasdaq: CYTK) ... 28 with patients and health care advocates in the ... Disease Day®. Rare Disease Day is dedicated to ... to the special challenges faced by patients with rare ... is proud to stand alongside patients and caregivers representing ...
(Date:2/26/2015)... 26, 2015 S&P Capital IQ (MHFI) announced ... coverage on MabVax Therapeutics Holdings Inc . ... stage biotechnology company focused on the development of vaccine ... the treatment of cancer. MabVax has discovered a pipeline ... immune responses generated by patients who have been immunized ...
(Date:2/26/2015)... 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... company that develops and commercializes proprietary technologies and products ... operational results for the fiscal first quarter ended December ... in Canadian dollars (CAD), unless otherwise stated. ... new business from our existing customers and add to ...
(Date:2/26/2015)... PARK, Calif. , Feb. 26, 2015 ... released the latest version of the Governance Portal ... accomplish governance, risk and compliance (GRC) tasks across multiple ... also been updated to help customers better align their ... of the Treadway Commission ) requirements. In response to ...
Breaking Biology Technology:Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 2Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 4Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 5Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 6S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 5SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3
... May 22, 2012 Genesis Biopharma, Inc. (OTC/BB: ... was mentioned favorably in an article in BioMedReports ... accessed at the following link: ... Inc. Genesis Biopharma, Inc. ...
...  Paratek Pharmaceuticals, Inc. today announced that Dennis ... been appointed President, Chief Executive Officer and Director, ... resignation earlier this year.  In addition, Evan Loh, ... Wyeth and who led regulatory approval for the ...
... of reflective metal can actually make something less visible, engineers ... invisible, light-detecting device that can "see without being seen." ... by a thin cap of gold. By adjusting the ratio ... to as tuning the geometries they capitalize on favorable ...
Cached Biology Technology:Genesis Biopharma Mentioned Favorably in BioMedReports Article 2Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 2Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 3Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 4Paratek Announces Appointments of Dennis Molnar as Chief Executive Officer and Director and of Dr. Evan Loh as Chief Medical Officer and Chairman of the Board of Directors 5Cloak of invisibility: Engineers use plasmonics to create an invisible photodetector 2Cloak of invisibility: Engineers use plasmonics to create an invisible photodetector 3
Mouse Wnt-9b Affinity Purified Polyclonal Ab Keywords: Wnt 9b Protein Family: Cancer Stem Cell Markers, Wnt Ligands...
One-step, microplate or cuvet, colorimetric, linear detection range 6 mg/dL to 100mg/dL. Procedure: 15 min....
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
EnzChek cellulase substrate *blue fluorescent, 339/452...
Biology Products: