Navigation Links
New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
Date:6/29/2009

Amsterdam, The Netherlands: A new test examining chromosomes in human eggs a few hours after fertilisation can identify those that are capable of forming a healthy baby, a researcher told the 25th annual conference of the European Society of Human Reproduction and Embryology today (Monday 29 June). Dr. Elpida Fragouli, from the Department of Obstetrics and Gynaecology, University of Oxford, UK, and Reprogenetics UK, said that her team's work had already enabled seven ongoing pregnancies in a group of older women with a history of multiple failed IVF attempts.

"Out of 35 patients who had embryo transfers after the test, we achieved a pregnancy rate of 20%, which is exceptional considering the extremely poor prognosis of the women involved." she said. "This represents a doubling of the usual pregnancy rate for women who fall into this category, which is otherwise, at best, under 10% and, at worst, zero. To date, we have two live births from this group, and all the other women who became pregnant have maintained their pregnancies. The study is continuing, and we believe that we will achieve more pregnancies with the help of this technology in the future."

The scientists used the Comparative Genomic Hybridisation (CGH) technique to count the chromosomes in each egg. Unlike conventional screening strategies, using the fluorescent in situ hybridisation (FISH) method, which allows less than half of the chromosomes of an embryonic cell to be examined, CGH enables the evaluation of the entire chromosome complement. CGH was used to examine the fertilised eggs by looking at polar bodies, tiny cells that are a by-product of egg development. The chromosomes of polar bodies provide an indication of whether the corresponding egg is normal or abnormal; if the polar bodies have the wrong number of chromosomes, so does the egg.

Looking at polar bodies is a less invasive way of obtaining information about the chromosome content of an egg and its result
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Invasive Australian jellyfish sighted in Gulf of Mexico in summer 2007
2. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
3. U of MN researchers discover noninvasive diagnostic tool for brain diseases
4. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
5. Minimally invasive heart surgery research wins NIH award
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. Smithsonian identifies invasive crab species in Panama Canal expansion area
8. Book on weeds and invasive plants discusses how to manage them using ecological approaches
9. A new baseline of invasive plants in Isabela
10. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11. Relationship between invasive plants, fire subject of new report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... This news release is available in German . ... for only a very few drugs. When treating overdoses, doctors ... Treatment is especially difficult if there is a combination of ... is playing and accidentally swallows his grandmother,s pills? ETH professor ... Zurich wanted to find an answer to this question. "The ...
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... the University of Leicester approaches the 25th anniversary of ... interested in a particular type of DNA are receiving ... Chimpanzees at Twycross Zoo in Leicestershire have been trained ... cheek swabs. Dr Richard Badge, of the University,s ...
... Louis, Sept. 6, 2009 An international team of ... Alzheimer,s disease. The findings are reported in the online ... The group, led by investigators from the School of ... scientists from Washington University School of Medicine in St. ...
... know often comes at the price of learning about more ... many, but not for those with conditions such as Alzheimer,s ... Using brain scans in monkeys, Duke University Medical ... switch from exploiting a known resource to exploring their options. ...
Cached Biology News:Zoo volunteers help explain mysteries of the genome 2Zoo volunteers help explain mysteries of the genome 3Researchers find 2 more genetic risk factors for Alzheimer's disease 2Monkey brains signal the desire to explore 2
(Date:10/20/2014)... Earle Martin , Chief ... that Ellen Teplitzky, an experienced attorney specializing in ... industry, has joined the firm as Director of ... practice. NDA Partners provides legal services, including ... to top law firms and their clients in ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The ... ABIM will take place at the Congress ... 2014 is now available at http://www.abim.ch ... and organizations from all over the globe ... the latest products and developments on the ...
(Date:10/19/2014)... October 19, 2014 The Asian Automatic ... Asian with analysis and forecast of revenue. The Automatic ... to around $463.9 million by 2018, at a developing ... through the TOC of the Asian Automatic patient billing ... provided. This also provides a glimpse of the segmentation ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems report ... and forecast of revenue. The Orthopedic braces and support systems ... million by 2018, at a developing CAGR of 4.4% from ... Asian Orthopedic braces and support systems market, to get an ... glimpse of the segmentation of orthopedic braces and support systems ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... SAN CARLOS, Calif., Jan. 8 Millions of ... some good news: the agency that,regulates Medicare and Medicaid ... treatment of sleep apnea., On December 14, 2007, ... policy memo proposing to allow coverage of Continuous,Positive Airway ...
... News briefs concerning the,economic and business growth ... Bay,Partnership:, Dental Supplier Announces Expansion of Tampa ... recently announced that it will merge two of ... and 144,employees in Manatee County, and Raintree, which ...
... N.J., Jan. 7 Quest Diagnostics,Incorporated (NYSE: ... information and services, announced that it is scheduled ... on Tuesday, January 8,2008, at the Westin St. ... is scheduled to begin at 11:00 a.m. Eastern ...
Cached Biology Technology:Medicare Coverage Recommended for In-Home Sleep Testing 2Highlights of Economic and Business Growth in the Tampa Bay Region 2Highlights of Economic and Business Growth in the Tampa Bay Region 3Highlights of Economic and Business Growth in the Tampa Bay Region 4Quest Diagnostics to Speak at the 26th Annual JPMorgan Healthcare Conference 2