Navigation Links
New $11 million center to speed production of new compounds for drug discovery
Date:10/20/2008

Scientists from three Chicago-area universities have joined forces to develop new ways of building state-of-the-art chemical libraries that will help identify new compounds for future drug development and basic biomedical research.

Scientists from the University of Chicago, Northwestern University and the University of Illinois at Chicago will establish the Chicago Tri-Institutional Center for Chemical Methods and Library Development with a $9.2 million grant from the National Institutes of Health. Furthermore, the Chicago Biomedical Consortium, which is funded by the Searle Funds at the Chicago Community Trust, has awarded a $2 million Lever grant to support the core infrastructure of the center and to make its resources available to the entire Chicago scientific community.

"In order to develop new drugs, you need to start with new compounds," said Center Director Sergey Kozmin, Associate Professor in Chemistry at the University of Chicago.

Kozmin's laboratory screens compounds specifically for their ability to kill cancer cells, but the chemical libraries that the Chicago Tri-Institutional Center produces will be readily available to many biology labs across the nation. The center also will broadly test for potential use against neurodegenerative disorders, infectious diseases and other therapeutic targets.

During the last two years, Kozmin's laboratory has used parallel organic synthesis, which enabled them to perform many reactions simultaneously, to build 3,000 new molecules in his search for anti-cancer compounds. Now he and his associates have the resources to build a facility next year in the Searle Chemistry Laboratory on the University of Chicago campus that will be able to synthesize new compounds 10 times as fast.

The new center's work will focus on the synthesis of what biologists call "small molecules," Kozmin said. "Compared to large proteins, organic molecules that become drugs are rather smal
'/>"/>

Contact: Steve Koppes
skoppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
2. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
3. L-1 Identity Solutions Awarded New Massachusetts RMV Drivers License Contract Valued at an Estimated $32 Million
4. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
5. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
6. £2 million study to reveal workings of dementia genes
7. Almost 7 million pregnant in sub-Saharan Africa infected with hookworms; at risk of anaemia
8. CCNY receives $5 million NSF grant to establish center for nanostructure applications
9. Burnham researcher awarded $8 million grant
10. NIEHS invests $21.25 million to find environmental causes of Parkinsons disease
11. Cornell gets $10 million NSF grant to establish new sustainability institute
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New $11 million center to speed production of new compounds for drug discovery
(Date:10/30/2014)... bioengineering professor has received a $1.04 million grant ... cartilage tissue and reduce osteoarthritis using a patient,s ... microscaffolding made of biodegradable polymers., Liping Tang, a ... department, said the research is primarily focused on ... battlefield., "We,ve found that if we inject microscaffolding ...
(Date:10/30/2014)... Rochelle, NY, October 30, 2014—Oligonucleotide-based therapeutics present unique ... to cause reproductive and developmental harm. New consensus ... the combined chemical and biological characteristics of these ... Therapeutics , a peer-reviewed journal from Mary ... available free on the Nucleic Acid Therapeutics ...
(Date:10/30/2014)... New York | Heidelberg, 30 October 2014 Biological ... a better understanding of adsorption of solution ions ... biological cells. Now, a new study provides a ... and surrounding solution ions. Joanna Kotyńska and Zbigniew ... the authors of a study describing these findings, ...
Breaking Biology News(10 mins):UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs 2Ion adsorption matter in biology 2
... launch of the International Giant Panda Genome Project. This announcement ... on January 2122, 2008, in Shenzhen, China. Dr. Hongmei Zhu, ... project is to finish the sequencing and assembling of the ... is a much loved animal all over the world and ...
... Calif., March 4 Atmel(R),Corporation (Nasdaq: ... PTEC ),announced today the integration of ... and SecureCore Pre-boot Authentication,(PBA) products., This ... industry leaders,provides for significantly stronger multifactor authentication ...
... the billions from Iceland,s Lake Myvatn are a force ... to breathe without inhaling the bugs, which hatch and ... short adult life, their carcasses blanket the lake, and ... surrounding landscape that the enhanced productivity can be measured ...
Cached Biology News:Giant panda genome to be sequenced 2Giant panda genome to be sequenced 3Atmel and Phoenix Technologies Collaborate to Create Next-generation Security Solutions for PCs 2Atmel and Phoenix Technologies Collaborate to Create Next-generation Security Solutions for PCs 3Lowly Icelandic midges reveal ecosystem's tipping points 2Lowly Icelandic midges reveal ecosystem's tipping points 3
(Date:10/31/2014)... -- Huge event with 36,000+ global professionals ... health, analysis and forecasting   CPhI Worldwide ... its most successful show to date with pre-audit figures ... this year in Paris , the ... 140+ countries representing every step of the pharmaceutical supply ...
(Date:10/31/2014)... Chicago, IL (PRWEB) October 30, 2014 ... tapped Insight Product Development’s decades-long heritage in successful ... real world context for what it takes to ... medical space. As part of a two-hour on-site ... University’s Kellogg school of business, McCormick School of ...
(Date:10/31/2014)... October 31, 2014 Following the successful ... free learning webinar to introduce its new product and ... and biostatisticians. , Launched in September, Formedix On Demand ... of clinical trial automation tools. For the first time, ... browser. And by introducing Formations – a revolutionary new ...
(Date:10/31/2014)... Brady (NYSE:BRC), a global leader in ... new video testimonial on the effectiveness of its ... technician at the BloodCenter of Wisconsin discusses the challenges ... hundreds of thousands of samples, and how the durability ... Brady, we design our label materials with the harsh ...
Breaking Biology Technology:CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 2CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 3CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 4CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 5CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 6Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Brady Debuts New Lab Label Testimonial Video 2
... N.J., June 26 Barr Pharmaceuticals,Inc. (NYSE: ... for Delaware has,ruled in favor of its subsidiary, ... listed by Boehringer Ingelheim Pharmaceuticals, Inc. in,connection with ... 1mg & 1.5mg., In his ruling, District ...
... Strive to Measure ROI, Balance Business Benefits with ... Environmental Responsibility, FALLS ... supply chains are most constrained by the,inability to justify cost of ... conducted by CSC (NYSE: CSC ), Manhattan,Associates Inc. (Nasdaq: ...
... -, NUTLEY, N.J., June 26 Roche announced ... allow U.S. businesses,to maintain access to their own stockpile ... upfront investment and more adaptability,to deal with unknown factors ... businesses pay a nominal annual fee to "reserve",their own ...
Cached Biology Technology:Barr Announces Favorable Ruling in Mirapex(R) Patent Challenge 2Barr Announces Favorable Ruling in Mirapex(R) Patent Challenge 3Barr Announces Favorable Ruling in Mirapex(R) Patent Challenge 4Study Reveals Greatest Barrier to Green Supply Chain Initiatives 2Study Reveals Greatest Barrier to Green Supply Chain Initiatives 3Roche Introduces Program to Facilitate Corporate Pandemic Stockpiling of Tamiflu(R) 2Roche Introduces Program to Facilitate Corporate Pandemic Stockpiling of Tamiflu(R) 3Roche Introduces Program to Facilitate Corporate Pandemic Stockpiling of Tamiflu(R) 4Roche Introduces Program to Facilitate Corporate Pandemic Stockpiling of Tamiflu(R) 5
... low temperature freezers offer a superior ... of biological samples with high capacities. ... inner doors ensure excellent warming protection ... ,Application oriented accessories simplify tracking of ...
...
Verotoxin IIbeta (457)...
... Universal Vacuum System UVS400 is a multi-tasking ... UVS400 combines a refrigerated vapor trap and ... single integrated unit. The easy-to-use, wide-mouth glass ... into single jar for easy disposal. The ...
Biology Products: