Navigation Links
Neuronal activity induces tau release from healthy neurons
Date:2/15/2013

HEIDELBERG, 15 February 2013 Researchers from King's College London have discovered that neuronal activity can stimulate tau release from healthy neurons in the absence of cell death. The results published by Diane Hanger and her colleagues in EMBO reports show that treatment of neurons with known biological signaling molecules increases the release of tau into the culture medi-um. The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity.

Tau proteins stabilize microtubules, the long threads of polymers that help to maintain the structure of the cell. However, in Alzheimer's disease or certain types of dementia, tau accumulates in neurons or glial cells, where it contributes to neurodegeneration.

In addition to intracellular aggregation, recent experiments have shown that tau is released from neuronal cells and taken up by neighboring cells, which allows the spread of aggregated tau across the brain. This release could occur passive-ly from dying neuronal cells, though some evidence suggests it might take place before neuronal cell death and neurodegeneration. The new findings indicate that tau release is an active process in healthy neurons and this could be altered in diseased brains.

"Our findings suggest that altered tau release is likely to occur in response to changes in neuronal excitability in the Alzheimer's brain. Secreted tau could therefore be involved in the propagation of tau pathology in tauopathies, a group of neurodegenerative diseases associated with the accumulation of tau proteins in the brain," commented Diane Hanger, Reader in the Department of Neuroscience at King's College London. In these experiments, Amy Pooler, the lead au-thor, revealed that molecules such as potassium chloride, glutamate or an AM-PA receptor agonist could release tau from cortical neurons in an active physio-logical process that is, at least partially, dependent on pre-synaptic vesi
'/>"/>

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers have identified a gene with a key role in neuronal survival
2. Ion selectivity in neuronal signaling channels evolved twice in animals
3. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
4. Cilia guide neuronal migration in developing brain
5. Activity in brain networks related to features of depression
6. High levels of TRAIL protein in breast milk might contribute to anticancer activity
7. NASAs new satellite movie of 1 weeks ash activity from Mexicos Popocatepetl Volcano
8. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
9. The activity of a bacterial effector protein seen in molecular detail
10. UTHealth study addresses barriers to physical activity counseling
11. Environmental estrogens affect early developmental activity in zebrafish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
(Date:6/25/2015)... , June 25, 2015 ... Sensors Market by Type (Swipe & Area), Technology, Material ... Government, Healthcare, Commercial Security & Others) & Geography ... by marketsandmarkets, the said market is expected to ... of 17.1%. Browse 76 market ...
(Date:6/24/2015)... The biologics safety testing market is growing ... market include growth of the pharmaceutical and biological industries ... the years, the number of drug approvals in North ... FDA approved 225 drug applications and Health Canada approved ... accounted for 3,822 of the pharmaceutical and ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... 2008 American Society for Microbiology (ASM) Siemens ... presented to Adrian M. Zelazny, Staff Scientist, ... Institutes of Health (NIH). This award recognizes ... antimicrobial therapy. Dr. Zelazny is honored ...
... of supercomputers have hardware set up not just for ... seemingly random data. And now, a multi-institutional group of ... for these supercomputers. Applications include anywhere complex webs of ... grid stability to complex biological networks. The ...
... from infecting other cells and triggering their destruction by ... HIV-infected individuals but eventually peters out. To find out ... Infectious Diseases examined the cells that make the antibodies, ... that HIV gradually depletes the numbers of healthy, functional ...
Cached Biology News:Multithreaded supercomputer seeks software for data-intensive computing 2Multithreaded supercomputer seeks software for data-intensive computing 3
(Date:7/27/2015)... -- Junto Health, a company that helps major health ... technology solutions, today announced the launch of a partnership ... health care policy consulting. Working together with SPG, Junto ... process while, at the same time, they are also ... care finance and the delivery of health care services.   ...
(Date:7/25/2015)... ... July 25, 2015 , ... Technology ... It precisely checks and adjusts the surface temperature of the measuring prism. This ... pharmaceutical industry, data traceability and documentation are key requirements. It is likely that ...
(Date:7/24/2015)... , July 24, 2015  Champions Oncology (OTC-BB: ... technology solutions and services to personalize the development and ... its financial and operational results for the fourth quarter ... Tuesday, July 28, 2015, before market open. ... the results that day at 9:00 a.m. EDT (6:00 ...
(Date:7/24/2015)... 2015 , Adds integrated small ... product offering for chronic kidney disease and oncology patients ... complications and dermatology , Increases group revenue and ... ,the Company"), a leading China -based ... biopharmaceutical products, today announced that it has acquired the ...
Breaking Biology Technology:Junto Health Announces a Unique Partnership with Sachs Policy Group 2Junto Health Announces a Unique Partnership with Sachs Policy Group 3Junto Health Announces a Unique Partnership with Sachs Policy Group 4It’s T-Time for Refractometers: On-site Temperature Check Now Available 2Champions Oncology to Announce Fourth Quarter Financial Results on Tuesday, July 28 23SBio Acquires Zhejiang Wansheng Pharmaceutical 23SBio Acquires Zhejiang Wansheng Pharmaceutical 33SBio Acquires Zhejiang Wansheng Pharmaceutical 4
... an information technology and Web products and services provider ... announced today that St. Luke,s Hospital & Health Network ... remote 24/7/365 IT infrastructure monitoring from CareTech,s Healthcare Infrastructure ... and monitoring of data, systems and applications located in ...
... innovative medical imaging informatics company, today announced the commercial ... Edition. Following the April release of their first commercial ... commercial version of their widely accepted DICOM ImageServer software, ... With the release of the PACS, Team Edition, ...
... windows which, thanks to a nanocoating, adjust their level ... to save energy; novel diagnostic methods and tailor-made nano-medicines ... one hand, can be used to make very efficient ... pheromones, protect vineyards from insect attack; new nanostructured materials ...
Cached Biology Technology:St. Luke's Hospital & Health Network Selects CareTech Solutions to Provide Proactive Monitoring of Hospital IT Infrastructure 2St. Luke's Hospital & Health Network Selects CareTech Solutions to Provide Proactive Monitoring of Hospital IT Infrastructure 3ClearCanvas Releases First Commercial Version of Widely Used PACS; Integrated RIS/PACS to Follow 2A world without nano? Soon hard to imagine 2A world without nano? Soon hard to imagine 3
... cell-based assays utilize the membrane-permeant ester ... negatively charged fluorescent beta-lactamase substrates, CCF2 ... enter the cell, where cleavage by ... into their negatively charged forms, thereby ...
...
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
...
Biology Products: