Navigation Links
Neuronal activity induces tau release from healthy neurons
Date:2/15/2013

HEIDELBERG, 15 February 2013 Researchers from King's College London have discovered that neuronal activity can stimulate tau release from healthy neurons in the absence of cell death. The results published by Diane Hanger and her colleagues in EMBO reports show that treatment of neurons with known biological signaling molecules increases the release of tau into the culture medi-um. The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity.

Tau proteins stabilize microtubules, the long threads of polymers that help to maintain the structure of the cell. However, in Alzheimer's disease or certain types of dementia, tau accumulates in neurons or glial cells, where it contributes to neurodegeneration.

In addition to intracellular aggregation, recent experiments have shown that tau is released from neuronal cells and taken up by neighboring cells, which allows the spread of aggregated tau across the brain. This release could occur passive-ly from dying neuronal cells, though some evidence suggests it might take place before neuronal cell death and neurodegeneration. The new findings indicate that tau release is an active process in healthy neurons and this could be altered in diseased brains.

"Our findings suggest that altered tau release is likely to occur in response to changes in neuronal excitability in the Alzheimer's brain. Secreted tau could therefore be involved in the propagation of tau pathology in tauopathies, a group of neurodegenerative diseases associated with the accumulation of tau proteins in the brain," commented Diane Hanger, Reader in the Department of Neuroscience at King's College London. In these experiments, Amy Pooler, the lead au-thor, revealed that molecules such as potassium chloride, glutamate or an AM-PA receptor agonist could release tau from cortical neurons in an active physio-logical process that is, at least partially, dependent on pre-synaptic vesi
'/>"/>

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers have identified a gene with a key role in neuronal survival
2. Ion selectivity in neuronal signaling channels evolved twice in animals
3. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
4. Cilia guide neuronal migration in developing brain
5. Activity in brain networks related to features of depression
6. High levels of TRAIL protein in breast milk might contribute to anticancer activity
7. NASAs new satellite movie of 1 weeks ash activity from Mexicos Popocatepetl Volcano
8. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
9. The activity of a bacterial effector protein seen in molecular detail
10. UTHealth study addresses barriers to physical activity counseling
11. Environmental estrogens affect early developmental activity in zebrafish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... pregnanteven with IVF? Here,s some hope: A new research ... The FASEB Journal , explains how scientists developed ... PAWP, which induced embryo development in human and mouse ... by the sperm cell during fertilization. , "We believe ... paradigm shift in our understanding of human fertilization by ...
(Date:9/30/2014)... 30, 2014  Spectra Automation, a trusted ... biotech and power generation industries, announced today ... Manager, an easy-to-use and cost-effective data collection, ... development laboratories. Most upstream ... analyzer systems. Accessing and consolidating data from ...
(Date:9/30/2014)... 2014) People who suffer from asthma may think ... their asthma besides properly taking medications and avoiding allergic ... the Annals of Allergy, Asthma and Immunology , ... Asthma and Immunology (ACAAI), asthma sufferers can learn lessons ... woman described in the Annals article improved her asthma ...
Breaking Biology News(10 mins):Synthetic sperm protein raises the chance for successful in vitro fertilization 2Spectra Automation Introduces RECONN Bioprocess Manager 2Asthma symptoms kicking up? Check your exposure to air pollution 2
... has named Louisiana Tech University School of Forestry Associate ... 2012 Carl Alwin Schenck Award winner. Holley received ... Convention held Oct. 24-28 in Spokane, Wash. The ... forestry education. This award recognizes individuals whose educational efforts ...
... Ozone affecting watersheds . . . ... have found that rising levels of ozone may amplify ... forests to rivers, streams and other water bodies. Such ... forest ecosystems and people in the southeastern United States. ...
... A team led by researchers at the University ... the "superbug" methicillin-resistant Staphylococcus aureus (MRSA) is ... is well known for causing difficult-to-treat and potentially fatal ... 1990s it has also been infecting otherwise healthy people ...
Cached Biology News:Louisiana Tech University professor earns national honor from Society of American Foresters 2November 2012 story tips 2Superbug MRSA identified in US wastewater treatment plants 2
(Date:9/30/2014)... D.C., September 30, 2014 Applying a well-known ... researchers at Harvard University has demonstrated the ability ... -- work that holds promise for making future, ... detailing the sides of next-gen rocket ships and ... light passes through oil in water, it becomes ...
(Date:9/30/2014)... , Sept. 30, 2014 Pacific Northwest ... Summary Global Markets Direct,s, ,Pacific Northwest ... provides an overview of the Pacific Northwest Biotechnology, ... report provides comprehensive information on the current therapeutic ... with comparative analysis at various stages, therapeutics assessment ...
(Date:9/30/2014)... NEW YORK , Sept. 30, 2014 /PRNewswire/ ... used to kill nematodes. Nematodes are microscopic parasitic ... soil, water, and inside other plants and animals. ... high volatility or other properties promoting migration through ... contain more than 1,000 plant-parasitic nematodes. With more ...
(Date:9/30/2014)... 2014 Follow us on LinkedIn ... type of cholesterol carrier or lipoprotein in the blood. ... cholesterol levels in the body, especially along the walls ... attack and other cardiovascular disorders. Cardiovascular Diseases (CVD) is ... cholesterol levels on a regular basis, to assess an ...
Breaking Biology Technology:Taking thin films to the extreme 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... F. Heil, Ph.D., senior vice president of research and development ... research and development company focused on the treatment of neurological ... Laval, Canada, at the invitation of the Canadian government/Laval Technopole, ... International Business Centre and The Biotech City on September 1 ...
... Champions Biotechnology, Inc. (OTC Bulletin Board: CSBR ... platforms and tumor specific data to enhance the value of ... 2011 first quarter ended July 31, 2010.  Full details of ... Form 10-Q at www.championsbiotechnology.com . Total revenues ...
... Health , Inc. (Nasdaq: GHDX ) today announced ... following conferences in September: Dean Schorno ... Stifel Nicolaus Healthcare Conference 2010 on Friday, September 17 at ... , Genomic Health,s Chief Operating Officer and Chief Financial Officer, ...
Cached Biology Technology:Curemark Attends North American Bio Forum at Canadian Government Invitation 2Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 2Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 3Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 4Genomic Health to Present at Two Upcoming Investor Conferences 2
... Thermo-Sealer is a manual heat sealer ideal for ... portable instrument can seal a wide range of ... carriers. The heating element of the sealer is ... or peelable seals when used in conjunction with ...
... controller is the successor to the original DS-U1. ... of the cameras in the Nikon DS camera ... interface. The DS-U2 transmits information at high speed, ... both hub and mass storage USB 2.0 interfaces. ...
...
This unique buffer provides a gentle method for removal of primary and secondary antibodies to allow several reprobings on the same membrane. Gentle buffer will not alter the antigen for subsequent i...
Biology Products: