Navigation Links
Need for speed
Date:3/18/2012

Like any law-abiding train passenger, a molecule called oskar RNA carries a stamped ticket detailing its destination and form of transport, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. They show that for this molecule, moving in the right direction isn't enough: speed is of the essence. Their study, published online today in Nature Structural & Molecular Biology, also provides clues as to how a single molecule could receive tickets for different destinations, depending on what type of cell it is in.

For a fruit fly embryo to develop properly, oskar RNA produced by the mother has to enter the egg cell, or oocyte, as it matures, and be taken to one of its ends the posterior pole. Researchers in Anne Ephrussi's group at EMBL have now found that this movement is more complicated than it seemed. When oskar is processed for transport by a mechanism called splicing, two different tags SOLE and EJC are attached to it, next to each other, at a specific spot. Ephrussi and colleagues found that both tags have to be in place for oskar to reach the right destination. Together, they seem to form a ticket that marks oskar for transport to the posterior pole, differentiating it from the many other RNAs that enter the oocyte bound for different destinations.

When they genetically altered the SOLE tag, the scientists found that oskar didn't go to the oocyte's posterior pole, as it should. But surprisingly, it did still move, and seemingly in the right direction. The problem, the researchers realised, was that oskar is racing towards a moving target. As the oocyte grows, it becomes longer, in effect taking the posterior pole further and further away as oskar is carried towards it. With a defective SOLE tag, oskar seemed unable to move fast enough to overcome the oocyte's growth. So somehow this 'ticket' affects the speed of transport, too.

Ephrussi and colleagues are now investigating
'/>"/>

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Grass to gas: UGA researchers genome map speeds biofuel development
3. New high-tech wound care products speed healing of ulcers, burns, injuries and surgical wounds
4. NJIT high speed rail expert to address DC conference next week
5. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
6. UCF nanotechnology may speed up drug testing
7. Georgia Tech develops speedy software designed to improve drug development
8. Genome-scale network of rice genes to speed the development of biofuel crops
9. Super-sized muscle made twin-horned dinosaur a speedster
10. Speed limit on babies vision
11. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Need for speed
(Date:11/21/2014)... NEW YORK , Nov. 19, 2014  Earlier ... Board at New York College, and one of the ... for biosensor signals that are transmitted from Smartphones to ... there were Smartphones and has one of the earliest ... are discussing its usage in the military, child care, ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
(Date:11/11/2014)... -- Forensicon, Inc., a Chicago -based digital ... promotion of Yaniv Schiff from Senior Computer ... new role as Director, he will lead company efforts ... and provide leadership within the company,s digital forensics practice ... Schiff joined Forensicon in 2006 and ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... DURHAM, N.H. New research by University of New ... is an effective tool for gauging exercise intensity, but ... assumed to other more objective tests. In a study ... associate professor of kinesiology Timothy Quinn and his former ...
... 13, 2011 AVT, Inc., (formerly Automated Vending ... revolutionize the vending and automated retailing industries by ... refills directly to consumers, 24-hours a day, without ... This breakthrough system uses advanced biometric ...
... role as an electric wire conveying an electrical signal. ... (synapse), various brain functions can occur. A neuron which ... many synapses located on those dendritic trees, and carries ... team of Associate Professor Kubota from The National Institute ...
Cached Biology News:New UNH data tests the exercise 'talk test' 2A 3-D reconstructed image of neural dendritic trees using the advanced electron microscope technology 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... DALLAS , July 21, 2010 ... Market - Advanced Technologies, Global,Forecast and Winning Imperatives (2009-2014)", ... is,expected to reach a $8.3 billion by ... knowledge management formed the largest submarket is 2009 at, ...
... 20, 2010The Life Sciences Discovery Fund (LSDF) today ... research teams to support commercial development of health-related ... the success rate of lumbar punctures (spinal taps) ... magnetic resonance imaging (MRI) contrast agent; enhancing a ...
... CAMPINA and PRAHOVA, Romania , July ... ), one of the,world,s leading biotechnology companies focusing on adult ... use traditional Chinese-style,rehabilitation techniques in Campina today. , ... ...
Cached Biology Technology:MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 2MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 3MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 4Life Sciences Discovery Fund announces commercialization grants 2Beike Biotechnology Opens First Chinese Rehabilitation Center in Romania 2Beike Biotechnology Opens First Chinese Rehabilitation Center in Romania 3Beike Biotechnology Opens First Chinese Rehabilitation Center in Romania 4
... Source: Crotalus adamanteus venom Description: ... widely used in studying nucleic ... . It hydrolyzes 5'-mononucleotides from ... . Phosphodiesterase I cleaves ADP-ribosylated ...
Economical and manually filled LN2 vacuum insulated storage container offers high capacity and low nitrogen consumption while offering convenient storage of samples....
... for the determination of digitonin and digoxin. Physical ... Na 4 and 0.06% NaCl Preparation Note: ... Biochem. Biophys. Res. Commun., 19, 755 (1965). ... of inorganic phosphorus from ATP per min at ...
... TURBO DNase (patent pending) in the TURBO DNA-free ... removal capabilities. TURBO DNase is a recombinant, engineered ... efficient than wild type DNase I in digesting ... binds DNA substrates 6-fold more tightly than traditional ...
Biology Products: