Navigation Links
Nature: Microscope looks into cells of living fish
Date:5/16/2012

This release is available in German.

Microscopes provide valuable insights in the structure and dynamics of cells, in particular when the latter remain in their natural environment. However, this is very difficult especially for higher organisms. Researchers of Karlsruhe Institute of Technology (KIT), the Max Planck Institute for Polymer Research, Mainz, and the American National Institutes of Health (NIH) have now developed a new method to visualize cell structures of an eighth of a micrometer in size in living fish larvae. It is published in the Nature Methods magazine (DOI:10.1038/nmeth.2025). "The zebrafish is perfectly suited for genetic studies of cells, as its larvae are completely transparent," explains Marina Mione, KIT. To visualize certain structures, these are colored mostly by genetic engineering methods using a fluorescent dye. Mione studied parts of the cellular skeleton of fish, the so-called microtubuli. The thread-shaped microtubuli have a length of about 100 m and a diameter of about 20 nm, corresponding to a hundred thousandth of a human hair. "Microtubuli exist everywhere in the cell and are required for its division and motion."

In the new microscopy method, the object is not illuminated completely, but only at a certain spot with special light. Scattered light is minimized and the illuminated detail is represented sharply. A series of images taken at variable illumination is then processed by a computer. In this way, an overall image is obtained. Smart illumination even allows to adjust the depth of field, to image various depth levels, and to combine them into a three-dimensional image on the computer. "Meanwhile, it is possible to reach resolutions of 145 nm in the plane and 400 nm in-between," says Marina Mione. The images are taken within a few seconds, such that movement of the cells does not cause any unsharpness.
'/>"/>

Contact: Monika Landgraf
presse@kit.edu
49-721-608-47414
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Changing the course of nature: Are fisheries directing the evolution of fish populations?
2. Commentary in Nature: Can economy bear what oil prices have in store?
3. Nature: Video reveals wave character of particles
4. Microscope reveals how bacteria breathe toxic metals
5. Computational microscope peers into the working ribosome
6. Compact microscope a marvel
7. New microscope reveals ultrastructure of cells
8. International conference puts food safety under the microscope
9. New microscope decodes complex eye circuitry
10. Brandeis researchers use lasers, custom microscope to show gene splicing process in real time
11. Big size multitouch display turned into a microscope
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nature: Microscope looks into cells of living fish
(Date:8/27/2014)... basic research, a growing focus on translating discoveries ... have earned the Herbert Irving Comprehensive Cancer Center ... NewYork-Presbyterian Hospital an $18 million, five-year Cancer Center ... The grant renews the center,s status as one ... New York City and one of only three ...
(Date:8/27/2014)... trans-fats have largely succeeded in sidelining the use ... for its potential contributions to Americans, health conditions. ... the best way to assuage the nation,s insatiable ... Chemical & Engineering News (C&EN), the weekly ... In the article, Stephen Ritter, a senior correspondent ...
(Date:8/27/2014)... thought to be associated with outcomes after the ... of the patient, mechanism of injury, nerve injured, ... operation technique, and repair materials. However, despite numerous ... nerve injuries, there is no agreement regarding the ... dose-effect relationship of the predictors has not been ...
Breaking Biology News(10 mins):Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... sciences professor Harris Lewin is a recipient of the ... with James R. Cook, of Washington State University. ... recipients in agriculture, chemistry, physics, mathematics, medicine and the ... significant discoveries" in the field of animal agriculture. ...
... from the Walter and Eliza Hall Institute have begun ... a key gene required for the process. The ... blood stem cells, unique ability to self-renew could give ... tissue repair, transplantation and other therapeutic applications. Professor ...
... This release is available in Spanish . ... refrigerators that an estimated 20 percent are lost to spoilage, ... with USDA,s Agricultural Research Service (ARS) are working with colleagues ... The research also may lead to tomatoes that taste better ...
Cached Biology News:Illinois professor awarded 2011 Wolf Prize in Agriculture 2Erg gene key to blood stem cell 'self-renewal' 2Finding a way to extend tomato shelf-life 2
(Date:8/26/2014)... what they believe is the thinnest-possible semiconductor, a ... only three atoms thick. , The University of ... single-layer semiconductor materials can be connected in an ... result could be the basis for next-generation flexible ... and solar technologies. , "Heterojunctions are fundamental elements ...
(Date:8/26/2014)... , Aug. 26, 2014 An analysis by ... of all Mers CoV virus strains has ... back to 2012.  This conservation and sharing of specific ... Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did for the ... both of which have been found to be effective ...
(Date:8/26/2014)... added to the growing case for graphene being ... thing in the high-tech world by the two-dimensional ... of researchers led by a scientist with the ... Laboratory (Berkeley Lab) has reported the first experimental ... materials. The recorded charge transfer time clocked in ...
(Date:8/26/2014)... Ga. , Aug. 26, 2014  ViveBio, ... biological sample collection, stabilization and transportation, announced today ... Laboratory Procurement Services, LLC (LPS) of ... of products in the United States ... new class of ambient temperature dried biological specimen ...
Breaking Biology Technology:Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2Competition for graphene 2ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2
... Transgenomic, Inc. (OTC/BB: TBIO) today reported financial results for ... business update. Second Quarter Financial ResultsNet sales ... increase of 50 percent compared with $5.1 million for the ... 59 percent of net sales, compared with gross profit of ...
... BETHESDA, Md., Aug. 11, 2011 The American College ... new ACMG Online Live Learning Center , which ... health care professionals. This valuable, on-demand resource brings the ... live learning offerings such as the Genetics Review Course ...
... GNVC ) today announced that its Board of ... through the adoption of a new Rights Agreement. The new ... 2011, which is the date that GenVec,s existing Rights Agreement ... in connection with the expiration of the existing Rights Agreement ...
Cached Biology Technology:Transgenomic Reports Second Quarter Financial Results 2Transgenomic Reports Second Quarter Financial Results 3Transgenomic Reports Second Quarter Financial Results 4Transgenomic Reports Second Quarter Financial Results 5Transgenomic Reports Second Quarter Financial Results 6Transgenomic Reports Second Quarter Financial Results 7Transgenomic Reports Second Quarter Financial Results 8Transgenomic Reports Second Quarter Financial Results 9ACMG Announces New Online Live Learning Center: Will Bring Genetics and Genomics Education to Varied Health Professionals 2GenVec Renews Stockholder Rights Plan 2GenVec Renews Stockholder Rights Plan 3
ANTI S. ENT TOX BC2D...
Porcine Serum US Origin 6 Months or Older...
... PlusOne Silver Staining Kit, Protein, ... Heukeshoven and Dernick (1), the kit ... gel electrophoresis systems.Silver Staining Kit, Protein ... of proteins in polyacrylamide gels in ...
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
Biology Products: