Navigation Links
'Natural killer' cells keep immune system in balance
Date:10/1/2009

PROVIDENCE, R.I. [Brown University] Natural killer, or NK cells, are part of our innate immune system. A healthy body produces them to respond early during infection. They are activated and they kill cells infected with a given virus.

It turns out NK cells are even more important to the body than previously thought. Researchers from Brown University and McGill University now know that the cells also help keep T cells major players in cell-mediated immunity from over-responding. Such a balance helps T cells maintain their role in the body's adaptive immune response, rather than becoming too numerous and activated to cause harm.

The discovery, published in the September issue of the Journal of Experimental Medicine, could someday be used to help treat patients with compromised immune systems. Managing NK cell production might help stabilize the immune systems of people with HIV or keep patients from rejecting bone marrow or organ transplants.

The findings place an importance on understanding how to keep NK cells around, because they can be lost, said lead author Christine Biron, professor of medical science at Brown University.

"The work reveals two important aspects of NK cell biology, the first piece being understanding how to keep NK cells instead of losing them," said Biron, the Esther Elizabeth Brintzenhoff Professor in the Department of Molecular Biology, Cell Biology and Biochemistry. "The second is that if you can keep them around, they have an important regulatory function to limit adaptive immune response. If you don't have them during long challenges, your adaptive immune system response could go unregulated and lead to death."

Scientists have known that NK cells have antimicrobial effects. But the newer research focuses on factors that help keep NK cells around. Through studying mice, researchers determined that the ability to keep NK cells around depends on whether they have a particular kind
'/>"/>

Contact: Mark Hollmer
Mark_Hollmer@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Barrow researcher finds natural hydrogel helps heal spinal cord
2. UCR Turfgrass Field Day to focus on water conservation, disease management, & natural turf
3. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
4. Restoring a natural root signal helps to fight a major corn pest
5. Salt marshes: A natural and unnatural history
6. Scientists link immune systems natural killer cells to infant liver disease
7. Natural compound stops retinopathy
8. Natural-born divers and the molecular traces of evolution
9. Natural seed treatment could drastically cut pesticide use
10. Small molecules mimic natural gene regulators
11. Rabbits on the back foot -- but naturally theyre fighting back
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Natural killer' cells keep immune system in balance
(Date:4/15/2014)... and Sciences (KNAW) has announced the names of five ... Prizes (one million US dollars prize money in total). ... merits to science. , This year marks the 50th ... Austrian-American chemist Erwin Chargaff in 1964. , KNAW ... following laureates: , Christopher M. Dobson, John ...
(Date:4/15/2014)... In recent years, it has become clear that ... previously assumed. In addition to the well-known building ... variations play an important role. Scientists now assume ... form a second layer of information that extends ... are rather like umlauts that extend the standard ...
(Date:4/15/2014)... 15, 2014 New research, partially funded by the ... shows that consumers can improve their diets simply by ... daily meals. , In a study ... Nutrition Sciences , lead author Theresa Nicklas, DrPH, of ... Nutrition Examination Survey datasets from 2005-2010 and evaluated the ...
Breaking Biology News(10 mins):Five scientists awarded prestigious Heineken Prizes 2German Research Foundation approves new priority program in the life sciences 2Eating rice boosts diet quality, reduces body weight and improves markers for health 2Eating rice boosts diet quality, reduces body weight and improves markers for health 3
... This press release is available in Spanish . ... radiotherapy to the lymph nodes located behind the breast bone ... breast conserving surgery, a radiation oncologist will tell delegates at ... March). Women at a high risk of developing breast cancer ...
... may shed light on how climate over millions of years ... that will discuss the findings and recommendations of the National ... Several members of the committee that wrote the report will ... next 10 to 20 years and answer audience questions. ...
... (LF) and the Nanyang Technological University (NTU) today announced ... to poor communities in the region with fresh funds, ... programme. The Lien Foundation is injecting a ... (Endeavour). Started in 2006, the Endeavour seeks to improve ...
Cached Biology News:Specific lymph node radiotherapy is well-tolerated after surgery in early breast cancer patients 2NTU and Lien Foundation launch second second wave of Environmental Endeavor 2NTU and Lien Foundation launch second second wave of Environmental Endeavor 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... (OTCBB: GNLK, "the Company," or "GeneLink"), a leading consumer ... year ended December 31, 2010. Financial Highlights: ... 2009 to $4,997,367 in 2010; Annual net sales ... 2009; Operating losses in 2010 decreased to $2,169,898, a ...
... SEATTLE, April 4, 2011 Omeros Corporation (NASDAQ: ... developing and commercializing products focused on inflammation, bleeding and ... Gregory A. Demopulos, M.D., chairman and chief executive officer, ... Healthcare Conference taking place in New York City this ...
... proteins, polymers, minerals, and engineered materials will be published ... Nature Materials . The discovery by two Penn State ... the structure of materials, which the researchers say greatly ... desired properties. The research is expected to have broad ...
Cached Biology Technology:GeneLink Reports 2010 Results 2Search for advanced materials aided by discovery of hidden symmetries in nature 2Search for advanced materials aided by discovery of hidden symmetries in nature 3
... Combining linear motor and ballscrew ... pre-engineered Cartesian solutions that include ... management, and motors., , ... Pass through high-flex cabling for ...
UGT1A6 (D-20)...
... T Squareds patented high efficiency dynamic valve ... With the most compact, lightweight package in ... use in portable air and gas applications., ... high efficiency. , Includes DC Motor. ...
... designed for moving loads quickly and accurately. ... output while limiting overall size. The P5S-P ... ball bearings guided on two rails., ... provide energy absorption and controlled deceleration , ...
Biology Products: