Navigation Links
'Natural killer' cells keep immune system in balance
Date:10/1/2009

PROVIDENCE, R.I. [Brown University] Natural killer, or NK cells, are part of our innate immune system. A healthy body produces them to respond early during infection. They are activated and they kill cells infected with a given virus.

It turns out NK cells are even more important to the body than previously thought. Researchers from Brown University and McGill University now know that the cells also help keep T cells major players in cell-mediated immunity from over-responding. Such a balance helps T cells maintain their role in the body's adaptive immune response, rather than becoming too numerous and activated to cause harm.

The discovery, published in the September issue of the Journal of Experimental Medicine, could someday be used to help treat patients with compromised immune systems. Managing NK cell production might help stabilize the immune systems of people with HIV or keep patients from rejecting bone marrow or organ transplants.

The findings place an importance on understanding how to keep NK cells around, because they can be lost, said lead author Christine Biron, professor of medical science at Brown University.

"The work reveals two important aspects of NK cell biology, the first piece being understanding how to keep NK cells instead of losing them," said Biron, the Esther Elizabeth Brintzenhoff Professor in the Department of Molecular Biology, Cell Biology and Biochemistry. "The second is that if you can keep them around, they have an important regulatory function to limit adaptive immune response. If you don't have them during long challenges, your adaptive immune system response could go unregulated and lead to death."

Scientists have known that NK cells have antimicrobial effects. But the newer research focuses on factors that help keep NK cells around. Through studying mice, researchers determined that the ability to keep NK cells around depends on whether they have a particular kind
'/>"/>

Contact: Mark Hollmer
Mark_Hollmer@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Barrow researcher finds natural hydrogel helps heal spinal cord
2. UCR Turfgrass Field Day to focus on water conservation, disease management, & natural turf
3. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
4. Restoring a natural root signal helps to fight a major corn pest
5. Salt marshes: A natural and unnatural history
6. Scientists link immune systems natural killer cells to infant liver disease
7. Natural compound stops retinopathy
8. Natural-born divers and the molecular traces of evolution
9. Natural seed treatment could drastically cut pesticide use
10. Small molecules mimic natural gene regulators
11. Rabbits on the back foot -- but naturally theyre fighting back
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Natural killer' cells keep immune system in balance
(Date:8/21/2014)... BATON ROUGE In a finding that has implications ... and planets elsewhere in the solar system, LSU Associate ... funded by the National Science Foundation, or NSF, this ... sediments of a lake that lies 800 meters (2600 ... sheet support "viable microbial ecosystems.", Given that more than ...
(Date:8/21/2014)... the water window? It consists of radiations in the ... by the water in biological tissues. New theoretical findings ... within the water window. These could be the basis ... of the biological samples or to be used in ... physical mechanism needed to efficiently generate the harmonic radiationswhich ...
(Date:8/21/2014)... in the journal Carcinogenesis by researchers at ... the protein adenomatous polyposis coli (APC) in suppressing colorectal ... the U.S. , Lead author Kristi Neufeld, associate professor ... the Cancer Biology program at the KU Cancer Center, ... to understand the various activities of APC, a protein ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4Water window imaging opportunity 2Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3
... A new genetic resource from an international research consortium ... and treatments for a wide range of human diseases. ... will increase the likelihood that experiments conducted in mice ... in the CC have 90 percent of the genetic ...
... LAKE CITY -- Climate change spells trouble for many ... forests and relatively small areas and the damage ... disease and competition among species. That is among ... studies relevant to the topic. The review was scheduled ...
... it matter whether long periods of hot weather, such as ... in June or July, August or September? Scientists studying ... when such events happen makes a big difference. Based ... Science Foundation (NSF) Konza Prairie Long-Term Ecological Research (LTER) site ...
Cached Biology News:New mouse collaborative cross resource promises new cures and treatments for diseases 2Climate change threatens tropical birds 2Climate change threatens tropical birds 3Climate change threatens tropical birds 4Climate change threatens tropical birds 5Time of year important in projections of climate change effects on ecosystems 2
(Date:8/21/2014)... scientists has observed tiny quantum vortices in cold droplets ... Science that the exotic vortices arrange themselves ... the first time that the quantum vortices, which have ... known as superfluid helium, have been detected in nanodroplets. ... Vilesov of the University of Southern California, one of ...
(Date:8/21/2014)... 21, 2014 ... announced the addition of the  "Global Hormone ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,Hormone ... is a means of replacing hormones that ... body. This type of therapy is usually ...
(Date:8/21/2014)... SPRING, N.Y. , Aug. 21, 2014 /PRNewswire/ ... the launch of their Nutraceutical "TELO-20 for Dogs" ... and only Telomere-lengthening supplement in the world for ... ends of every chromosome in the body. A ... world,s leading experts in Telomere Science and Aging, ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources Group ... Brazil and Mexico ... of several newly approved agents, the anticipated label ... and the launch of emerging biologics will substantially ... particular, the emerging IL-5 inhibitors will introduce a ...
Breaking Biology Technology:Scientists observe quantum vortices in cold helium droplets 2Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
... RDEA ) today announced that preclinical data will be presented on,the ... (DDW) 2008 in San Diego., The oral presentation details ... 20, 2008 at 3:30 p.m. Pacific Time ... Ameliorates Murine Colitis ...
... ST. LOUIS, May 14 Sigma-Aldrich (Nasdaq:,SIAL) announced today ... Hogan will retire at a date to be determined ... the Company early this,year of his desire to retire ... transitioned. The Company has initiated a search to,identify a ...
... LLC,MDAC is proud to announce that it has engaged ... success optimizing investments in,the medical device market as board ... Tony Dimun, CEO of Nascent Enterprises, LLC, formerly of ... PhD, Chairman and CEO of SomaLogic Inc., and formerly ...
Cached Biology Technology:Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at Digestive Disease Week 2008 2Sigma-Aldrich (Nasdaq: SIAL) CAO & CFO Hogan Plans to Retire; Search for Successor Underway 2MEDdevice Acquisition Co., LLC Announces Board Members and Advisors 2
...
Collected from sexually matured, mixed breed, mixed sex guinea pigs....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
DTT, 25g...
Biology Products: