Navigation Links
Natural chemical found in broccoli helps combat skin blistering disease
Date:8/20/2007

Johns Hopkins scientists have found yet another reason why you should listen to your mother when she tells you to eat your vegetables. Sulforaphane, a chemical present at high levels in a precursor form in broccoli and related veggies (cauliflower, Brussels sprouts, etc.), helps prevent the severe blistering and skin breakage brought on by the rare and potentially fatal genetic disease epidermolysis bullosa simplex (EBS).

The researchers treated newborn mice with a severe form of EBSso bad they all died within three dayswith a topical solution containing sulforaphane and found marked improvement; after four days more than 85 percent of the treated mice were alive and blister-free. These findings appear online this week in Proceedings of the National Academy of Sciences.

The basis of EBS, notes study author Pierre Coulombe, Ph.D., professor of biological chemistry, lies in two specific genes that make proteins known as keratins. Normally, the keratins join together and form highly resilient fibers in the lower portion of skin, helping make it durable. If either keratin is defective, they dont mesh and the lower skin tissue becomes unusually fragile and gets damaged from the mildest mechanical stress leading to blistering pain, a higher risk of infection, and in the most severe cases, death.

Humans have around 54 distinct keratins, many of which are similar in structure and function, says Coulombe. We figured we might be able to exploit this similarity and dial up a replacement by triggering the activation of a suitable signaling pathway in skin. He predicted that sulforaphane might stimulate the formation of a surrogate skin-strengthening keratin to stand in for the defective one.

The desire to learn more about sulforaphane led Coulombe and his co-workers to Paul Talalay, M.D., professor of pharmacology who had previously identified sulforaphane as a cancer-preventive agent. It turns out that treatment with low doses of su
'/>"/>

Contact: Nick Zagorski
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. UCLA scientists store materials in cells natural vaults
6. Man-made wetlands effectiveness similar to natural marsh
7. Natural Killers Could Lead to New Hepatitis Treatments
8. Researchers pioneer new gene therapy technique using natural repair process
9. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Naturally occurring asbestos linked to lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... 7, 2014  In conjunction with the Glendale ... The Community Foundation of the Verdugos has announced the " ... PROJECT," a $250,000 initiative to keep the Verdugo Regional Crime ... first six months of existence, the Lab has processed more ... local law enforcement. "Because our number one priority ...
(Date:11/6/2014)... 6, 2014 - Insilico Medicine, Inc, a Baltimore-based ... age related diseases announced a research collaboration with ... Champions Oncology, Inc (OTC: CSBR). , "There are ... medicine, but Champions Oncology,s TumorGraft technology is unique ... chemotherapy regimen experimentally generating vast amounts of valuable ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... shady pursuit of endangered bird eggs made international headlines ... most notorious illegal egg collector, died after falling from ... The Royal Society for the Protection of Birds estimates ... are targeted by collectors. Classical economics theory predicts that ...
... world's oceans to land about 415 million years ago, then ... record contains few examples of animals with backbones for the ... again, this time for good. , The mysterious lull in ... for the Yale University paleontologist, Alfred Romer, who first recognized ...
... games this holiday season because the fun of playing ... , Psychologists at the University of Rochester, in collaboration ... 1,000 gamers what motivates them to keep playing. The ... month suggest that people enjoy video games because they ...
Cached Biology News:A human taste for rarity spells disaster for endangered species 2A human taste for rarity spells disaster for endangered species 3Steep oxygen decline halted first land colonization by Earth's sea creatures 2A reason why video games are hard to give up 2
(Date:11/26/2014)... and WILMINGTON, DE (PRWEB) November 26, 2014 ... Annual MPN Heroes recognition reception on December 5, 2014, ... Hematology’s annual meeting. The MPN Heroes event will honor ... in the field of myeloproliferative neoplasms (MPNs). , ... "Nashville," will discuss his family's cancer journey at the ...
(Date:11/26/2014)... -- Bio-Techne Corporation (NASDAQ: TECH ) announced ... to serve in a newly created position of Senior ... will be responsible for managing the operations of Bio-Techne,s ... acquired in July 2014 and the recently acquired CyVek ... -based ProteinSimple develops and commercializes proprietary systems and consumables ...
(Date:11/24/2014)... Nov. 24, 2014  IGI Laboratories, Inc. (NYSE MKT: ... specialty generic pharmaceutical company, today announced it has submitted ... U.S. Food and Drug Administration (FDA), which brings the ... seven, with eighteen submissions now pending at the FDA. ... CEO of the Company, commented, "Our team here at ...
(Date:11/24/2014)... NAMUR , Belgium , Nov. 24, ... life sciences company focused on developing diagnostic tests for cancer ... lung cancer study will be presented at the Science for ... Louvain-la-Neuve, Belgium . The data come from ... collected at the Pneumology department of the Centre Hospitalier Universitaire ...
Breaking Biology Technology:CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3IGI Laboratories, Inc. Announces ANDA Submission 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
... October 20 Speaking in Rome, Italy today ... Foundation,(IOF) CEO Patrice McKenney called for individuals and ... osteoporosis. "Osteoporosis is a common but,devastating disease which ... taken to reduce the burden of osteoporotic fractures ...
... Air Force-funded researcher, Dr. scar Custance from the National Institute ... 2009 Feynman Prize for Experimental Work in Nanotechnology for his ... research could someday lead to more effective catalysts for the ... experimental work will be awarded in January 2010 near Palo ...
... Neurobiological Technologies, Inc. (Nasdaq: NTII ) ("NTI") announced ... Market LLC ("NASDAQ") that NTI intends to file a Form ... about October 28, 2009 to effect the voluntary delisting of ... dissolution of the company pursuant to a Plan of Complete ...
Cached Biology Technology:World Osteoporosis Day Call for Immediate Action to Prevent Fractures 2Researcher honored for experimental work in nanotechnology 2
... a DNA sequencing service. We can sequence ... products, BACs, etc. Our DNA sequencing service ... plasmids or purified PCR products. We use ... automated reaction setup and dye terminator removal. ...
... The BD FACSAria cell sorter sets ... cytometry. Based on a revolutionary new ... delivers high-speed sorting and multicolor analysis. The ... sorter that incorporates a fixed-alignment cuvette flow ...
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
...
Biology Products: