Navigation Links
Natural chemical found in broccoli helps combat skin blistering disease
Date:8/20/2007

Johns Hopkins scientists have found yet another reason why you should listen to your mother when she tells you to eat your vegetables. Sulforaphane, a chemical present at high levels in a precursor form in broccoli and related veggies (cauliflower, Brussels sprouts, etc.), helps prevent the severe blistering and skin breakage brought on by the rare and potentially fatal genetic disease epidermolysis bullosa simplex (EBS).

The researchers treated newborn mice with a severe form of EBSso bad they all died within three dayswith a topical solution containing sulforaphane and found marked improvement; after four days more than 85 percent of the treated mice were alive and blister-free. These findings appear online this week in Proceedings of the National Academy of Sciences.

The basis of EBS, notes study author Pierre Coulombe, Ph.D., professor of biological chemistry, lies in two specific genes that make proteins known as keratins. Normally, the keratins join together and form highly resilient fibers in the lower portion of skin, helping make it durable. If either keratin is defective, they dont mesh and the lower skin tissue becomes unusually fragile and gets damaged from the mildest mechanical stress leading to blistering pain, a higher risk of infection, and in the most severe cases, death.

Humans have around 54 distinct keratins, many of which are similar in structure and function, says Coulombe. We figured we might be able to exploit this similarity and dial up a replacement by triggering the activation of a suitable signaling pathway in skin. He predicted that sulforaphane might stimulate the formation of a surrogate skin-strengthening keratin to stand in for the defective one.

The desire to learn more about sulforaphane led Coulombe and his co-workers to Paul Talalay, M.D., professor of pharmacology who had previously identified sulforaphane as a cancer-preventive agent. It turns out that treatment with low doses of su
'/>"/>

Contact: Nick Zagorski
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. UCSD discovery may help extend life of natural pesticide
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
5. UCLA scientists store materials in cells natural vaults
6. Man-made wetlands effectiveness similar to natural marsh
7. Natural Killers Could Lead to New Hepatitis Treatments
8. Researchers pioneer new gene therapy technique using natural repair process
9. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
10. Natural tumor suppressor in body discovered by UCSD medical researchers
11. Naturally occurring asbestos linked to lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... de septiembre de 2014 Agilent ... Infinity II LC, el nuevo instrumento de ... portafolio de cromatografía líquida. El sistema permite ... laboratorio que alcancen nuevos niveles de eficiencia ... y capacidad de integración de laboratorio. ...
(Date:9/22/2014)... that after a long stay in the Intensive Care ... remain behind in patients, intestines. The team tested these ... when provoked by conditions that mimic the body,s stress ... mBio , the online open-access journal of the American ... treatment of ICU patients who can develop a life-threatening ...
(Date:9/22/2014)... cut grass in recent years has been identified as ... says the aroma also summons beneficial insects to the ... plant signals the environment via the emission of volatile ... for parasitic wasps to come to the plant that ... insect," said Dr. Michael Kolomiets, Texas A&M AgriLife Research ...
Breaking Biology News(10 mins):Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 2Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 3Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 2Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 3Mown grass smell sends SOS for help in resisting insect attacks, researchers say 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 3
... newborn rabbit pups to learn the significance of new odors, ... milk may act as a chemical booster that facilitates the ... opportunity to nurse. , The findings, which deepen our ... earliest days of life, are reported in the October 10th ...
... at St. Jude Children's Research Hospital turned up the ... these unruly molecules perform critical functions in the cell. ... investigation and classification of these so-called intrinsically unstructured proteins ... roles in the daily activities of cells. , ...
... to manipulate the brain's perception of jaw movement while ... the importance of non-auditory sensory cues in the brain's ... Nasir and David Ostry of McGill University and appear ... Biology, published by Cell Press. , When we ...
Cached Biology News:Pheromone from mother's milk may rapidly promote learning in newborn mammals 2First major study of mammalian 'disorderly' proteins 2Sensory feedback during speech: The brain attunes to more than just sound 2
(Date:9/23/2014)... TORONTO , Sept. 23, 2014 /PRNewswire/ - Portage ... Canadian Securities Exchange: PBT.U), is pleased to announce ... (PPL) has added two more  consultants to its ... uveitis. PPL-003 uses a new proprietary cell permeable ... deliver its anti-inflammatory cargo into the eye. ...
(Date:9/23/2014)... , September 23, 2014 ... System Transfer     Devices  (CSTD) for ... with Taiwanese distributor MedFront Medical Technology Corporation.  Equashield,s leading CSTD ... Taiwan , China ... company continues to expand globally, and throughout the ...
(Date:9/23/2014)... New York (PRWEB) September 23, 2014 ... from around the globe will convene at ... International Conference, to be held October 26-28 ... in evidence-based research and practice in individualized ... physicians, scientists, researchers, nurses, psychologists, nutritionists, naturopaths, ...
(Date:9/22/2014)... MA (PRWEB) September 22, 2014 Pearl's ... scientific breakthrough in drought tolerant grass seed this week ... grass seed. The announcement coincides with the fact that ... the Spring as many believe. , As of ... rave and favorable reviews by industry experts and the ...
Breaking Biology Technology:Portage Announces New Consultants for its PPL-003 Development Programs 2Portage Announces New Consultants for its PPL-003 Development Programs 3Portage Announces New Consultants for its PPL-003 Development Programs 4Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2
... , , , , , , ... The term transgenic animals describes animals whose chromosomes , contain stably integrated ... not normally found in the host animal. , For this reason, ... foreign DNA into oocytes or embryos (blastocysts). , , , ...
...
... , , , , , ... acids , and proteins has established itself as a ... measurements in the ultraviolet and in the visibility , ... nm and colorimetric protein determination is carried out in the ...
Cached Biology Technology:Transgenic Animals 2Transgenic Animals 3Transgenic Animals 4Transgenic Animals 5Transgenic Animals 6Transgenic Animals 7Transgenic Animals 8Transgenic Animals 9Quantification made easy 2Quantification made easy 3
Human LAIR2 Biotinylated Affinity Purified PAb...
... The mycobacteria in Complete Freund's ... the injection site which enhances the immuneresponse. ... is used for the initial injections; Incomplete ... boosts. Antigens (preferably in saline) are typically ...
2,4-Dinitrophenyl hapten is conjugated to Human Serum Albumin (HSA) protein through lysine....
Alexa Fluor 350/488/594 Filter Set (Semrock Brightline) *mounted* *Zeiss Axio AF...
Biology Products: