Navigation Links
National Science Foundation awards $1 million to improve the efficiency of DNA fabrication
Date:7/26/2012

The National Science Foundation (NSF) has awarded a three-year $999,531 grant to Virginia Tech to optimize the laboratory processes used to make custom DNA molecules with the tools and methods of industrial engineering. The interdisciplinary team led by Jean Peccoud, Associate Professor at the Virginia Bioinformatics Institute also includes Kimberly Ellis and Jaime Camelio, Associate Professors in the Grado Department of Industrial and Systems Engineering, at Virginia Tech.

The concept of DNA fabrication has its roots in synthetic biology, an emerging area of biological research that applies engineering methods to design, build, and characterize artificial biological systems that meet user-defined specifications. DNA fabrication combines natural and chemically synthetized DNA fragments together in order to make larger DNA molecules that conform to computer-designed sequences.

DNA fabrication includes gene synthesis, the process of assembling chemically synthesized oligonucleotides into double-stranded DNA fragments. It also includes more traditional activities such as the development of mutant collections or libraries of plasmid expressing families of proteins. In this broad perspective, most biologists practice DNA fabrication, although they are more likely to call it molecular biology or genetic engineering.

"The reward of this project is a much-needed increase in productivity of the life science research enterprise. Our national R&D infrastructure needs to be more fiscally responsible in these times of constrained budgets. In order to enhance U.S. competitiveness, it is necessary to find ways of producing more data, more discoveries, and more applications with stable or shrinking resources," said Peccoud. "We are proposing a change of paradigm in laboratory management that will enable American biotechnology companies to create manufacturing jobs for people who did not have a chance to receive a college education."

DNA fabrication projects rely on low-cost instruments and laboratory infrastructure commonly available to life scientists. Unfortunately, the lack of a suitable framework to analyze DNA fabrication now limits its effectiveness. "The process of assembling a DNA molecule corresponding to a user-defined sequence is similar to the process of making a mechanical part that requires casting, turning, and milling operations based on CAD drawings provided by a customer," said Ellis, Site Director for the Center for Excellence in Logistics and Distribution. "DNA fabrication processes are similar to complex job shops producing customized products for specific customers in a variety of production volumes."

"This project will provide unique cross-training opportunities in biology and engineering for undergraduate students, graduate students, and post-doctoral fellows," said Camelio, Director of the Virginia Tech Graduate Program in Industrial and Systems Engineering. "It will give industrial engineering students an opportunity to explore a new frontier. Life science students will gain exposure to management techniques that will help them streamline the operation of their labs in academia or industry after they graduate."


'/>"/>
Contact: Aleta Todd Delaplane
aleta9@vbi.vt.edu
540-231-6966
Virginia Tech
Source:Eurekalert  

Related biology news :

1. International regulation curbs illegal trade of caviar
2. The International Society for Advancement of Cytometry presented its 2012 awards at CYTO 2012
3. International congress on behavior, animal husbandry and animal well-being in Vienna
4. Rice receives $1 million INSPIRE award from National Science Foundation
5. 500 international cloud researchers meet in Leipzig
6. Story tips from the Department of Energys Oak Ridge National Laboratory, July 2012
7. Elsevier launches International Journal for Parasitology: Parasites and Wildlife
8. Israel to set up National Center for Mediterranean Sea Research, headed by U of Haifa
9. WALTHAM® demonstrates commitment to scientific dialogue and exchange at international human animal interaction conference
10. Nitrogen pollution changing Rocky Mountain National Park vegetation, says CU-Boulder-led study
11. 12th International Coral Reef Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
National Science Foundation awards $1 million to improve the efficiency of DNA fabrication
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... Baltimore, MD (PRWEB) , ... April 27, 2016 ... ... appointed Greg Lamka, PhD to its Scientific Advisory Board. Dr. Lamka will assist ... of plant pathogen detection. , PathSensors deploys the CANARY® test platform for ...
(Date:4/27/2016)... ... ... Global Stem Cells Group and the University of Santiago Biotechnology Lab have ... for potential stem cell protocol management for 2016 – 2020. , In 2015, ... establish a working agenda and foster initiatives to promote stem cell research and development ...
(Date:4/26/2016)... ANGELES, Calif. (PRWEB) , ... April 27, 2016 ... ... Angeles office of Lewis Roca Rothgerber Christie LLP as an associate in the ... prosecuting U.S. and international electrical, mechanical and electromechanical patent applications. He has an ...
(Date:4/26/2016)... ... April 26, 2016 , ... Heidelberg ... the latest technology innovation for its Volume Pattern Generator (VPG) line of lithography ... of advanced photomasks as well as a solution for mid volume direct write ...
Breaking Biology Technology: