The National Science Foundation (NSF) has awarded a three-year $999,531 grant to Virginia Tech to optimize the laboratory processes used to make custom DNA molecules with the tools and methods of industrial engineering. The interdisciplinary team led by Jean Peccoud, Associate Professor at the Virginia Bioinformatics Institute also includes Kimberly Ellis and Jaime Camelio, Associate Professors in the Grado Department of Industrial and Systems Engineering, at Virginia Tech.
The concept of DNA fabrication has its roots in synthetic biology, an emerging area of biological research that applies engineering methods to design, build, and characterize artificial biological systems that meet user-defined specifications. DNA fabrication combines natural and chemically synthetized DNA fragments together in order to make larger DNA molecules that conform to computer-designed sequences.
DNA fabrication includes gene synthesis, the process of assembling chemically synthesized oligonucleotides into double-stranded DNA fragments. It also includes more traditional activities such as the development of mutant collections or libraries of plasmid expressing families of proteins. In this broad perspective, most biologists practice DNA fabrication, although they are more likely to call it molecular biology or genetic engineering.
"The reward of this project is a much-needed increase in productivity of the life science research enterprise. Our national R&D infrastructure needs to be more fiscally responsible in these times of constrained budgets. In order to enhance U.S. competitiveness, it is necessary to find ways of producing more data, more discoveries, and more applications with stable or shrinking resources," said Peccoud. "We are proposing a change of paradigm in laboratory management that will enable American biotechnology companies to create manufacturing jobs for people who did not have a chance to receive a college education."
|Contact: Aleta Todd Delaplane|