Navigation Links
National Institutes of Health to fund research probing proteins linked to cancer, diabetes

Researchers from the Polytechnic Institute of New York University (NYU-Poly) and NYU have received a grant from the National Institutes of Health (NIH) to further a novel approach to understanding the genetic underpinnings of diseases including cancer and diabetes.

Jin Kim Montclare, associate professor of chemical and molecular engineering at NYU-Poly, and Yingkai Zhang, associate professor of chemistry at NYU, have teamed to study the functioning of one of the key proteins in human DNA, called histone. Histones are scaffolding proteins that organize DNA within the cell nucleus, and they are subject to modifications by enzymes that affect gene expression, both in health and disease.

Zhang and Montclare are combining their expertise in computational chemistry and protein engineering, respectively, to shed new light on one of the key enzymes that modify histones, histone acetyltransferases (HATs).

"HATs play an essential role in gene regulation, and while we know that aberrant or mutated HATs are associated with diseases like cancer and diabetes, we don't understand their precise catalytic mechanisms," explained Montclare. "If we can understand the processes by which these proteins can modify histones and how mutations can lead to disease, we move closer to creating targeted therapies to prevent or reverse these changes."

The researchers' collaborative approach is unique, and has not been explored for HATs. Zhang will create a computational study of the mechanics of HATs, offering what may be the most detailed picture of their workings. This sets the stage for Montclare's work, of engineering and testing the HATs and designed variants for reactivity on histones.

"Bringing computational powers to bear on these processes will not only elucidate the underpinnings of the enzymes as they exist now, but will allow us to run simulations to test the impact of modifications and therapies to reverse the kinds of changes linked to disease," Zhang said.

The National Institutes of Health grant will provide $1.2 million over four years.


Contact: Kathleen Hamilton
Polytechnic Institute of New York University

Related biology news :

1. PETA International Science Consortium disappointed in denial of Dow appeal
2. First international collaboration to showcase latest body of evidence of dairy health benefits
3. SPIE on global team proposing International Year of Light at United Nations
4. CLEO: 2013 -- the Premier International Laser and Electro-Optics Event in San Jose next week
5. The German National Academy of Sciences Leopoldina makes recommendations for the G8 summit
6. CARE Pharmacies Joins National Association of Specialty Pharmacy (NASP) as a Founding Corporate Member
7. Save the date: American Chemical Society National Meeting, Sept. 8-12, 2013, in Indianapolis
8. 2 UCLA faculty elected to National Academy of Sciences
9. Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame
10. New National Inventors Hall of Fame inductees received vital NSF support
11. Freeman elected to National Academy of Science
Post Your Comments:
(Date:11/19/2015)... Nov. 19, 2015  Although some 350 companies are ... by a few companies, according to Kalorama Information. These include ... of the market share of the 6.1 billion-dollar molecular ... World Market for Molecular Diagnostic s .    ... is still controlled by one company and only a ...
(Date:11/18/2015)... 18, 2015 --> ... new market report titled  Gesture Recognition Market - Global ... - 2021. According to the report, the global gesture recognition market was ... to reach US$29.1 bn by 2021, at a CAGR ... North America dominated the global gesture recognition ...
(Date:11/17/2015)... Paris , qui s,est tenu ... Paris , qui s,est tenu du 17 au ... l,innovation biométrique, a inventé le premier scanner couplé, qui ... même surface de balayage. Jusqu,ici, deux scanners étaient nécessaires, ... digitales. Désormais, un seul scanner est en mesure de ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica ... on AngelList early in their initial angel funding process. Now, they are paying ... looking to make early stage investments in the microbiome space. In this, ...
(Date:11/24/2015)... , Nov. 24, 2015 Cepheid (NASDAQ: ... speaking at the following conference, and invited investors to ... NY      Tuesday, December 1, 2015 at 11.00 ... NY      Tuesday, December 1, 2015 at 11.00 ... Conference, New York, NY      Tuesday, ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... healthy metabolism. But unless it is bound to proteins, copper is also toxic ... (NIH), researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic study of ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
Breaking Biology Technology: