Navigation Links
National Academy of Sciences honors geneticist and biologist Sue Biggins
Date:1/8/2013

SEATTLE Sue Biggins, Ph.D., a geneticist and biologist at Fred Hutchinson Cancer Research Center, has received the National Academy of Sciences Award in Molecular Biology. Sponsored by Pfizer Inc., the award consists of a $25,000 prize in recognition of a recent notable discovery by a young scientist.

She was among 18 honored by NAS this year for outstanding achievements in a wide range of fields spanning the physical, biological and social sciences.

Biggins, a member of the Fred Hutch Basic Sciences Division, was recognized for her work in understanding the mechanics of cell division. She recently made an important contribution to the field by figuring out how to isolate the specialized cellular machines known as kinetochores that allow cells to separate and accurately distribute their chromosomes.

For decades, researchers have tried and failed to isolate or assemble whole, functioning kinetochores to better understand how they help chromosomes separate and end up in the right daughter cells. If this goes awry, entire chromosomes are gained or lost, a hallmark of most cancers, birth defects and miscarriages.

Biggins' team, stepping away from genetic methods and borrowing from biochemists' playbook, for the first time succeed in separating the kinetochores from dividing yeast cells and studying them in test tubes.

During cell division, kinetochores act like handles on chromosomes and are under tremendous pressure as fibers pull on these handles to move the chromosomes within the dividing cell. If chromosomes fall off in the midst of this process, they don't end up in the daughter cell. Biggins and colleagues, in collaboration with the laboratory of Chip Asbury, Ph.D., in the Physiology and Biophysics Department at the University of Washington, found the harder the kinetochores are pulled, the harder they attach, like a finger-trap toy. This counterintuitive characteristic explains why the process works correctly so ofte
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. International study suggests human genes influence gut microbial composition
2. January 2013 story tips from Oak Ridge National Laboratory
3. President Obama honors MU researcher with National Medal of Science
4. Spanish consumers prefer national fish
5. Barbara Gilchrest named 2012 Charter Fellow by National Academy of Inventors
6. National Academy of Inventors names four UT Arlington professors as charter fellows
7. LSUHSCs Weiss chosen to help set national eye policy, research
8. U of M to lead international virtual institute studying climatic and human effects on Earth
9. International Drug & Explosives Detection Company IDenta Corp. Article to be Published by Zillion International
10. Elk bones tell stories of life, death, and habitat use at Yellowstone National Park
11. National Geographic unveils new phase of genographic project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... only marketing directed at children on the interior ... that the majority of black, middle-income and rural ... , Authored by Arizona State University researcher Punam ... first to examine the use of child-directed marketing ... restaurants and its relationship to demographics. It adds ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and Markets ... "Cell Therapy - Technologies, Markets and Companies" to their ... therapy technologies and methods, which have already started to play ... cell transplantation is replacing the old fashioned bone marrow transplants. ... therapy is bound to become a part of medical practice. ...
(Date:11/2/2014)... of Physics World , James Dacey explores the ... death" to take their innovations from the lab into ... challenge facing all start-up companies as they move from ... of two main factors: physics-based inventions are usually far ... out to be a lot more complicated than had ...
Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3The 'valley of death' facing physics start-ups 2
... human survival and food security, especially as population density ... social insects to cultivate crops, have harvested plant material ... years. New results from the Smithsonian show that both ... coming into the nest inside leaves, thus ensuring the ...
... year, hundreds of thousands of people suffer medical complications ... skin. A new device developed by MIT engineers and ... needles on target. The device, which is purely ... industry. It involves a hollow S-shaped needle containing a ...
... has joined with a team of colleagues to propose ... research field that investigates heritable alterations in gene expression ... Dr. Shilatifard,s publication appeared today in ... meeting on December 7-10, 2008 that he co-organized at ...
Cached Biology News:Food security for leaf-cutting ants: Workers and their fungus garden reject endophyte invaders 2MIT: Novel needle could cut medical complications 2Ali Shilatifard and colleagues aim to clarify the definition of 'epigenetics' 2
(Date:11/26/2014)... SoundConnect , an award winning unified communications ... Darren Suders has joined the team as Director of ... partner program through innovative offerings, consistent partner ... brings more than 10-years of channel telecommunication experience to ... from policy development, to partner education and to expansion. ...
(Date:11/26/2014)... , Nov. 25, 2014 Bio-Techne Corporation ... has appointed Robert Gavin to serve in ... the Protein Platforms Division.  Mr. Gavin will be responsible ... segment, which includes the ProteinSimple business acquired in July ... San Jose, California -based ProteinSimple develops ...
(Date:11/24/2014)... -- Five American winners will receive the ... for Medical Sciences", in its 8 th term; ... , on 15 December 2014.      (Photo: ... Center which won the Hamdan Award for Volunteers in ... that aim to improve health and promote peace and ...
(Date:11/24/2014)... Nov. 24, 2014   Veracyte, Inc. (Nasdaq: ... , president and chief executive officer, will present in a ... Annual Healthcare Conference on Tuesday, December 2, 2014 at 12:30 ... The live audio webcast and subsequent replay may be ... connect to the website at least 15 minutes prior to ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Five US Winners Among Recipients of Hamdan Medical Awards 2Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2
... 13, 2011 Tengion, Inc. (NASDAQ: TNGN ... new data from the Company,s Neo-Urinary Conduit™ (NUC) and ... at the TERMIS North America Annual Conference being held ... NUC program is further supported by various cellular and ...
... Dec. 13, 2011  Astellas Pharma Inc. (Tokyo: 4503, Astellas) ... from an interim analysis of a Phase 2 study ... were presented at the 53rd Annual Meeting of the ... Data were also presented from two additional posters: one ...
... PHILADELPHIA, Dec. 13, 2011 Tarsa Therapeutics today confirmed ... Application (NDA) to the Food and Drug Administration (FDA) ... company,s oral recombinant salmon calcitonin tablet for the treatment ... the FDA that verified the results from Tarsa,s Phase ...
Cached Biology Technology:Tengion Presents New Scientific Data in Presentations at TERMIS North America Annual Meeting 2Tengion Presents New Scientific Data in Presentations at TERMIS North America Annual Meeting 3Tengion Presents New Scientific Data in Presentations at TERMIS North America Annual Meeting 4Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 2Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 3Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 4Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 5Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 6Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 7Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 8Tarsa Therapeutics Targets 2012 NDA Submission for its OSTORA™ Oral Calcitonin 2Tarsa Therapeutics Targets 2012 NDA Submission for its OSTORA™ Oral Calcitonin 3
... whose sequence is from the C-terminal end of the mouse retinoic acid ... acids 429 to 448 of RAR*. The sequence of PEP-005 is ... S - P - S - S - V - E - ... S - P - L - L - Q (The N-terminal ...
... Kit with Medium High quality ready-to-use cryopreserved ... base medium for growth and lineage commitment. ... generated from E18 fetal rat brain in ... mixture of in vitro stem/progenitor cells, neurons, ...
... for the use of small interfering RNA ... the RNA interference (RNAi) pathway have generated ... biology fields. siRNA for experimental use can ... enzymatically, and then transfected into the target ...
... for the use of small interfering RNA ... the RNA interference,(RNAi) pathway have generated tremendous ... fields. siRNA for experimental use can be,synthesized ... then transfected into the target cells in ...
Biology Products: