Navigation Links
Nanotechnology breakthrough could dramatically improve medical tests
Date:5/31/2012

A laboratory test used to detect disease and perform biological research could be made more than 3 million times more sensitive, according to researchers who combined standard biological tools with a breakthrough in nanotechnology.

The increased performance could greatly improve the early detection of cancer, Alzheimer's disease and other disorders by allowing doctors to detect far lower concentrations of telltale markers than was previously practical.

The breakthrough involves a common biological test called an immunoassay, which mimics the action of the immune system to detect the presence of biomarkers the chemicals associated with diseases. When biomarkers are present in samples, such as those taken from humans, the immunoassay test produces a fluorescent glow (light) that can be measured in a laboratory. The greater the glow, the more of the biomarker is present. However, if the amount of biomarker is too small, the fluorescent light is too faint to be detected, setting the limit of detection. A major goal in immunoassay research is to improve the detection limit.

The Princeton researchers tackled this limitation by using nanotechnology to greatly amplify the faint fluorescence from a sample. By fashioning glass and gold structures so small they could only be seen with a powerful electron microscope, the scientists were able to drastically increase the fluorescence signal compared to conventional immunoassays, leading to a 3-million-fold improvement in the limit of detection. That is, the enhanced immunoassay would require 3 million times fewer biomarkers to be present compared to a conventional immunoassay. (In technical terms, the researchers measured an improvement in the detection limit from 0.9 nanomolars to 300 attomolars.)

"This advance opens many new and exciting opportunities for immunoassays and other detectors, as well as in disease early detection and treatment," said Stephen Chou, the Joseph C. E
'/>"/>

Contact: Steven Schultz
sschultz@princeton.edu
609-258-3617
Princeton University, Engineering School
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Europe rallies behind nanotechnology to wean world from fossil fuels
2. Nanotechnology boosts war on superbugs
3. NIST, NCI bring web 2.0 tools to nanotechnology standards effort
4. Nanotechnology culture war possible, says Yale study
5. Donation for new Center for Pharmaceutical Nanotechnology and Nanotoxicology
6. Nanotechnology holds promise for STD drug delivery
7. University awarded £1.7M to develop nanotechnology for use in health care
8. Singapore nanotechnology combats fatal brain infections
9. New DNA test uses nanotechnology to find early signs of cancer
10. Nanotechnology and synthetic biology: What does the American public think?
11. Step forward for nanotechnology: Controlled movement of molecules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanotechnology breakthrough could dramatically improve medical tests
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
(Date:9/1/2014)... 2014, 10:20 AM EDT) It may be possible ... over unhealthy higher-calorie foods, according to new research by ... Center on Aging (USDA HNRCA) at Tufts University and ... journal Nutrition & Diabetes , a brain scan ... is possible to reverse the addictive power of unhealthy ...
(Date:9/1/2014)... and decisions of the Nomenclature Section of the XVIII ... July 2011. This meeting is held every six years ... the rules for naming algae, fungi and plants get ... naming the organisms they study. This is the primary ... for algae, fungi, and plants, which was published in ...
Breaking Biology News(10 mins):Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3Training your brain to prefer healthy foods 2Week-long meeting on naming algae, fungi, and plants recorded for posterity 2
... microbe samples while preserving the microbes, natural gene expression ... varieties of small RNAs snippets of RNA that ... single-celled creatures. Before now, small RNA could only be ... in a natural setting may make it possible finally ...
... Jersey Chapter of the American Society of Civil Engineers ... to John Schuring, Stabile Professor for Innovation and Technology ... expert, contact Sheryl Weinstein at 973-596-3436.) Schuring, ... has 35 years of experience in the areas of ...
... Jersey Chapter of the American Society of Civil Engineers ... to John Schuring, Stabile Professor for Innovation and Technology ... expert, contact Sheryl Weinstein at 973-596-3436.) Schuring, ... has 35 years of experience in the areas of ...
Cached Biology News:MIT reels in RNA surprise with microbial ocean catch 2MIT reels in RNA surprise with microbial ocean catch 3Civil engineers name NJIT's John Schuring Educator of Year 2Civil engineers name NJIT's John Schuring Educator of Year Award 2
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and ... candidates to participate in an investigational study of donor ... goal of this study is to determine if a ... two arthritically affected joints can help reduce pain and ... the current investigational study must be older than nine ...
(Date:8/29/2014)... MA (PRWEB) August 29, 2014 A ... in the biotech start-up dense realm of Boston-Cambridge, is ... and able investors. James Sherley, the Director of Boston’s ... increasing the local and national visibility of his company ... September 2013. , In addition to a social media ...
(Date:8/28/2014)... Nevada City, CA (PRWEB) August 28, 2014 ... and sanitation products for the food processing industry, is ... conducting a side-by side comparison of the E2 soap ... Q E2 Sanitizing Foam Soap . Hand hygiene ... pathogens in the food processing environment. Six key criteria ...
(Date:8/28/2014)... new research platform uses a laser to ... undergoing stress and heating, an approach likely ... microelectronics and batteries., This new technique, called ... heating and the surface stress of microscale ... discussed the merits of surface-stress influence on ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... Sept. 30 DOR BioPharma, Inc. (OTC Bulletin Board: SNGX), ... a corporate name change from DOR BioPharma, Inc. to Soligenix, ... name change, the Company,s shares of common stock will immediately ... today. , "We are pleased to announce the ...
... 30 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. (TSX-V: QPT) ... and commercializing products for the treatment of cancer, ... of late-stage immunotherapy product candidates from Paladin Labs ... candidates consists of five monoclonal antibodies targeting certain ...
... , ... application enables system access and security for federal employees, regardless of location , ... Miami, FL (PRWEB) September ... landmark partnership with the Ministry of Health in Spain, providing the agency with software-based ...
Cached Biology Technology:DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 2DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 3DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 4Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 2Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 3Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 4Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 2Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 3
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
RABBIT ANTI HUMAN APP (KP1 DOMAIN) Immunogen: Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP....
... (CMV) pp65 Antigenemia Immunofluorescence Assay (IFA) is ... matrix protein pp65 of CMV in isolated ... Erythrocyte Lysis Buffer - ... mL of buffered ammonium chloride. (NH4CL) ...
Biology Products: