Navigation Links
'Nanosponge vaccine' fights MRSA toxins
Date:12/1/2013

Nanosponges that soak up a dangerous pore-forming toxin produced by MRSA (methicillin-resistant Staphylococcus aureus) could serve as a safe and effective vaccine against this toxin. This "nanosponge vaccine" enabled the immune systems of mice to block the adverse effects of the alpha-haemolysin toxin from MRSAboth within the bloodstream and on the skin. Nanoengineers from the University of California, San Diego described the safety and efficacy of this nanosponge vaccine in the December 1 issue of Nature Nanotechnology.

The nanosponges at the foundation of the experimental "toxoid vaccine" platform are bio-compatible particles made of a polymer core wrapped in a red-blood-cell membrane. Each nanosponge's red-blood-cell membrane seizes and detains the Staphylococcus aureus (staph) toxin alpha-haemolysin without compromising the toxin's structural integrity through heating or chemical processing. These toxin-studded nanosponges served as vaccines capable of triggering neutralizing antibodies and fighting off otherwise lethal doses of the toxin in mice.

Toxoid vaccines protect against a toxin or set of toxins, rather than the organism that produces the toxin(s). As the problem of antibiotic resistance worsens, toxoid vaccines offer a promising approach to fight infections without reliance on antibiotics.

"With our toxoid vaccine, we don't have to worry about antibiotic resistance. We directly target the alpha-haemolysin toxin," said Liangfang Zhang, a nanoengineering professor at UC San Diego Jacobs School of Engineering and the senior author on the paper. Targeting the alpha-haemolysin toxin directly has another perk. "These toxins create a toxic environment that serves as a defense mechanism which makes it harder for the immune system to fight Staph bacteria," explained Zhang.

Beyond MRSA and other staph infections, the nanosponge vaccine approach could be used to create vaccines that protect against
'/>"/>

Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Nanosponges soak up oil again and again
2. New malaria vaccines roadmap targets next generation products by 2030
3. A new DNA vaccine induces a Th2 immune response in Alzheimers disease mice
4. Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine
5. Reassuring findings released in national study of influenza vaccine safety in pregnancy
6. New investment fund will advance late-stage vaccines, other global health technologies
7. Scientists closer to universal flu vaccine after pandemic natural experiment
8. University of Maryland researchers studying vaccine to prevent potential bird flu pandemic
9. Scientists engineer strain of MERS coronavirus for use in a vaccine
10. IDRI and Zydus sign agreement for development of IDRIs vaccine candidate for visceral leishmaniasis
11. New materials, progress toward an HIV vaccine, and more at meeting of crystallographers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Nanosponge vaccine' fights MRSA toxins
(Date:5/19/2015)... , May 18, 2015 Fingerprint Cards ... FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if its ... until and including Q3 2015 and the sensors will be ... Communicated order values for 2015 hereby amount to 740 MSEK ... 2015 of 140 MSEK and a number of smaller orders ...
(Date:5/18/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/11/2015)... Calif. , May 11, 2015  Synaptics ... of human interface solutions, today announced the appointment ... President and Chief Financial Officer, reporting to ... replaces Synaptics, current Chief Financial Officer, Kathleen ... 2014. Mr. Ali brings extensive ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... Spring Harbor, NY Bread wheat ( Triticum aestivum ) ... for 20% of the calories consumed by people. Fully 35% ... crop for survival. Now an international team of scientists, including ... the first comprehensive analysis of its full genome. ...
... During its two-year duration, pro-iBiosphere aims to ... for an integrative system (= sphere) for intelligent (= ... becomes operational, the European Open Biodiversity Knowledge Management System ... of core biodiversity data. It will create an authoritative ...
... 26, 2012Analysis published by the U.S. Department of Agriculture,s ... issue of the journal Science examine the ... development (R&D) and their importance in agricultural input industries. ... recent ERS study that provides new details on the ...
Cached Biology News:Bread wheat's large and complex genome is revealed 2Bread wheat's large and complex genome is revealed 3Toward an European open biodiversity knowledge management system 2USDA study shows trends in public and private agricultural R&D 2
(Date:5/25/2015)... , May 26, 2015  PureTech, a science-driven healthcare ... challenges in disruptive ways, announced today that Dame ... former CEO of Pearson, has been appointed to PureTech,s ... Director and that current Board member Joi Ito ... Chairman. Dr. Ben Shapiro , PureTech,s outgoing Chairman ...
(Date:5/25/2015)... (PRWEB) May 25, 2015 The ... Chloride Industry is a professional and in-depth study ... Hydrogen Chloride Market with a focus on ... hydrogen chloride market research are Linde Industrial Gas, ... Yuanhua Chemical, Shandong Xinlong Group, Longsheng Group, Juhua ...
(Date:5/22/2015)...  Actavis plc (NYSE: ACT ) today confirmed ... for the Second Circuit has issued a ruling upholding ... to continue distribution of NAMENDA ® (memantine HCl) ... "While we are disappointed by the ... continue our strong efforts to convey the significant benefits ...
(Date:5/22/2015)... 22, 2015 Charm Sciences, Inc. ... of Agriculture (USDA), Grain Inspection, Packers and Stockyards ... to Charm Sciences to monitor aflatoxin in grains ... and ROSA FAST Aflatoxin Quantitative Test (solvent-based). , ... uses Water Extraction Technology to extract aflatoxin ...
Breaking Biology Technology:PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 2PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 3Global Hydrogen Chloride Industry 2015 Trends and Analysis Available in a New Report at DeepResearchReports.com 2Global Hydrogen Chloride Industry 2015 Trends and Analysis Available in a New Report at DeepResearchReports.com 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2
... devastating, currently incurable motor-neuron disease spinal muscular atrophy (SMA) ... of RNA called antisense oligonucleotides (ASOs). Scientists ... Pharmaceuticals have succeeded in reversing symptoms of Type III ... mice by introducing an ASO into their spinal cords. ...
... of researchers from Delft University of Technology announces a new ... we screen DNA molecules, for example to read off their ... (published online in Nano Letters ), they report a ... graphene (a carbon layer with a thickness of only 1 ...
... - Ocean Nutrition Canada (ONC) supplier of the most trusted source ... acquisition of the exclusive global marketing and distribution rights to GAT ... , , ... acquired the rights to exclusive use of GAT,s unique and patented ...
Cached Biology Technology:CSHL researchers demonstrate efficacy of antisense therapy for spinal muscular atrophy 2CSHL researchers demonstrate efficacy of antisense therapy for spinal muscular atrophy 3DNA through graphene nanopores 2Ocean Nutrition Canada Announces Acquisition of Exclusive License to GAT Food Essentials, Omega-3 Microencapsulation-Emulsion Technology 2Ocean Nutrition Canada Announces Acquisition of Exclusive License to GAT Food Essentials, Omega-3 Microencapsulation-Emulsion Technology 3