Navigation Links
Nanoparticles can overcome drug resistance in breast cancer cells
Date:11/7/2013

Nanoparticles filled with chemotherapeutic drugs can kill drug-resistant breast cancer cells, according to a study published in the scientific journal Biomaterials.

Nanoparticles are just as small, or even smaller, than many blood proteins. They can therefore pass through the walls of healthy and sick cells, which make them interesting carriers of drugs against cancer and other diseases.

In the present study, researchers from Karolinska Institutet have shown that nanoparticles made from biodegradable plastics can overcome drug resistance in breast cancer cells. Such resistance is especially common in relapsing cancer patients and depresses, even neutralises the effect of the therapy against the tumour in many instances.

In their experiments, the researchers used breast cancer cells that responded poorly to drugs owing to their high concentrations of the enzyme microsomal glutathione S-transferase-1 (MGST-1). Abnormally high levels of MGST-1 have been associated with poor responses to several cancer drugs. The team treated the resistant breast cancer cells with nanoparticles filled with doxorubicin, a chemotherapeutic used clinically to treat bladder, lung, ovarian and breast cancer, amongst others.

"Our experiments on cultivated cells showed that the particles themselves are harmless," says research team member Dr Andreas Nystrm, Associate Professor at the Institute of Environmental Medicine, Karolinska Institutet. "We made it possible for the nanoparticles carrying the drug to kill resistant cancer cells by controlling where in the cancer cell they delivered their payload. This improved the efficacy of the drug even at a much lower dose, which is important for limiting the adverse reactions to therapy."

Nanoparticles can also be used to control where the drug is delivered in the body, and the team is now planning to equip them with targeting groups such as peptides or antibodies, that direct them to spec
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Making complex nanoparticles easily reproducible
2. Gold nanoparticles give an edge in recycling CO2
3. Stealth nanoparticles lower drug-resistant tumors defenses
4. Researchers figure out why gold nanoparticles can penetrate cell walls
5. Nanoparticles, pH phoresis could improve cancer drug delivery
6. MU researchers develop radioactive nanoparticles that target cancer cells
7. Trackable drug-filled nanoparticles -- a potential weapon against cancer
8. X-rays reveal uptake of nanoparticles by soya bean crops
9. Achilles heel: Popular drug-carrying nanoparticles get trapped in bloodstream
10. Nanoparticles reach new peaks
11. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles can overcome drug resistance in breast cancer cells
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... to play a major role in the studies ... a life-threatening parasitic disease that kills nearly one ... advanced our understanding of malaria, new models are ... Institute for Mathematical and Biological Synthesis (NIMBioS) is ...
... 18, 2011 -- Physicists and bioengineers have developed an ... a worm just by shining a tightly focused beam ... The pioneering optogenetic research, by a team at Harvard ... Massachusetts Medical School, is described this week in the ...
... the first view of DNA damage throughout the entire ... a valuable new insight into the development and treatment ... Dr Simon Reed and Dr Yumin Teng from Cardiff ... a unique way of measuring DNA damage frequency using ...
Cached Biology News:Malaria modeling and control focus of workshop 2Sharply focused on neurons, light controls a worm's behavior 2New technology provides first view of DNA damage within entire human genome 2
(Date:5/21/2015)... YORK , May 21, 2015  Susan ... Research (FPWR), a nonprofit organization dedicated to supporting ... Prader-Willi syndrome (PWS), announced today that FPWR has ... and Irina Shaulov contributed $1 million ... clinical initiatives.  ...
(Date:5/21/2015)... uBiome, the leading startup focused ... PicnicHealth, a healthcare company that collects and consolidates ... Bowel Disease (IBD) will receive a complementary PicnicHealth ... kit. Both companies were funded by Y Combinator ... more information on this partnership and how to ...
(Date:5/21/2015)... 2015 Imagine being able to ... those of others. Being able to read faces and ... people to anticipate their thoughts and actions like never ... feelings to create unique abstract paintings and video, or, ... inside a first-person-shooter as it creates action, dialog, and ...
(Date:5/21/2015)... Patent Offering, The patent’s technology pertains ... therapeutic imaging within a body lumen (open space). ... a low cost, single-use disposable illumination and camera module ... 18, 2013 and the patent approval was received on ... to customize the lighting and magnification of the endoscope ...
Breaking Biology Technology:The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 35 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3
... Louvain, Belgium Cancer is the major cause of ... predict that, by about 2010, cancer will be the ... VIB scientists connected to the Katholieke Universiteit Leuven, in ... studying the anti-cancer action of anti-PLGF. This substance appears ...
... Delft University of Technologys Kavli Institute of Nanoscience and ... succeeded in controlling the spin of a single electron ... for a much simpler realization of the building blocks ... publish their work in Science Express on Thursday 1 ...
... BioFuel Energy Corp. (Nasdaq:,BIOF) announced today that ... Wednesday, November 7, 2007, after the market closes. ... plans to host a conference call on Thursday, ... discuss the third quarter results. To,participate, please dial ...
Cached Biology Technology:On the road to a new cancer therapy -- starving the tumor 2On the road to a new cancer therapy -- starving the tumor 3Delft University of Technology rotates electron spin with electric field 2
...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... MasterAmp™ Taq DNA Polymerase is a ... aquaticus. Having optimal activity at temperatures ... thermostable enzyme used for PCR and ... purpose. The enzyme has an intrinsic ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
Biology Products: