Navigation Links
Nanoparticles can overcome drug resistance in breast cancer cells
Date:11/7/2013

Nanoparticles filled with chemotherapeutic drugs can kill drug-resistant breast cancer cells, according to a study published in the scientific journal Biomaterials.

Nanoparticles are just as small, or even smaller, than many blood proteins. They can therefore pass through the walls of healthy and sick cells, which make them interesting carriers of drugs against cancer and other diseases.

In the present study, researchers from Karolinska Institutet have shown that nanoparticles made from biodegradable plastics can overcome drug resistance in breast cancer cells. Such resistance is especially common in relapsing cancer patients and depresses, even neutralises the effect of the therapy against the tumour in many instances.

In their experiments, the researchers used breast cancer cells that responded poorly to drugs owing to their high concentrations of the enzyme microsomal glutathione S-transferase-1 (MGST-1). Abnormally high levels of MGST-1 have been associated with poor responses to several cancer drugs. The team treated the resistant breast cancer cells with nanoparticles filled with doxorubicin, a chemotherapeutic used clinically to treat bladder, lung, ovarian and breast cancer, amongst others.

"Our experiments on cultivated cells showed that the particles themselves are harmless," says research team member Dr Andreas Nystrm, Associate Professor at the Institute of Environmental Medicine, Karolinska Institutet. "We made it possible for the nanoparticles carrying the drug to kill resistant cancer cells by controlling where in the cancer cell they delivered their payload. This improved the efficacy of the drug even at a much lower dose, which is important for limiting the adverse reactions to therapy."

Nanoparticles can also be used to control where the drug is delivered in the body, and the team is now planning to equip them with targeting groups such as peptides or antibodies, that direct them to spec
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Making complex nanoparticles easily reproducible
2. Gold nanoparticles give an edge in recycling CO2
3. Stealth nanoparticles lower drug-resistant tumors defenses
4. Researchers figure out why gold nanoparticles can penetrate cell walls
5. Nanoparticles, pH phoresis could improve cancer drug delivery
6. MU researchers develop radioactive nanoparticles that target cancer cells
7. Trackable drug-filled nanoparticles -- a potential weapon against cancer
8. X-rays reveal uptake of nanoparticles by soya bean crops
9. Achilles heel: Popular drug-carrying nanoparticles get trapped in bloodstream
10. Nanoparticles reach new peaks
11. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles can overcome drug resistance in breast cancer cells
(Date:6/23/2015)... , June 23, 2015   Valencell, ... the results of a recent study that illustrates ... the wrist during activity. In a study conducted ... compared along with the Apple Watch against a ... heart rate during activity. The study demonstrated that ...
(Date:6/18/2015)... June 18, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market announces that its Wocket® ... on "Money on the Mark", scheduled to air on WABC ... June 20 th . The broadcast air- ... 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino Pereira ...
(Date:6/17/2015)... , June 17, 2015  Synaptics Inc. ... interface solutions, today announced that Xiaomi, one of ... Synaptics ® ClearPad ® family of ... driver integrated circuits (DDICs) for its latest smartphones, ... leveraging ClearPad for full in-cell display solutions and ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... , , , WALL, ... Bulletin Board: BKYI), a leader in finger-based biometric ... of the world,s most respected security publications, named ... in the Access Control sub-category Biometrics. , (Logo: ...
... San Diego are developing new regenerative therapies for heart ... regenerative therapies for cardiovascular and other diseases are treated ... Diego on using adult stem cells to regenerate heart ... were presented this week in San Diego at the ...
... GAINESVILLE, Fla. University of Florida researchers have found ... dosage of a highly toxic, debilitating chemotherapy drug to achieve ... is needed before the therapy can be tested in patients, ... mice with established human tumors suggests that the addition of ...
Cached Biology News:BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 3Supportive materials will help regenerate heart tissue 2Small addition to cancer drug may make big difference 2Small addition to cancer drug may make big difference 3
(Date:7/1/2015)... July 1, 2015  Axovant Sciences Ltd. (NYSE: ... the treatment of dementia, today announced that the ... 22 at 5:45 p.m. EDT following its presentation ... International Conference 2015 (AAIC). The ... , Dr. Lawrence Friedhoff , Chief Development ...
(Date:7/1/2015)... , ... July 01, 2015 , ... A newly launched ... ideas to lower the barriers to innovation in life sciences R&D. The Pistoia Alliance ... two cash prizes of US$15,000 and a period of expert mentorship from a senior ...
(Date:7/1/2015)... Indianapolis, IN (PRWEB) , ... July 01, 2015 , ... ... the 2015 BIO International Convention in Philadelphia, PA. , The presentation took ... milestones and outlined the plans for the development of APX3330 for the treatment of ...
(Date:7/1/2015)... 1, 2015  UCB, a multinational biopharmaceutical company, ... leader in designing, transforming, and running intelligent business ... recognition of their close collaboration in driving transformation ... business services (GBS) finance organization. The ... that work together effectively to embrace the innovative ...
Breaking Biology Technology:Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... International Holdings, Inc. (NYSE Amex: BONE ... graft material and antimicrobial coatings for medical applications, signed ... in the U.S. and Canada of Jeil,s LeForte System. ... implants used in craniomaxillofacial procedures, including trauma and reconstruction, ...
... Nov. 27, 2011  Candelis announced today that it has ... MSFT ) whereby Candelis, ASTRA cloud-hosted suite of services ... medical images and studies to patients, Microsoft HealthVault accounts ... a personal health application platform that lets consumers gather, ...
... Led by a group at the University of Maryland ... materials research and an age-old metallurgy technique to produce ... new class of sensors and micromechanical devices controlled by ... is notable, among other things, for not using rare-earth ...
Cached Biology Technology:Bacterin Signs Distribution Agreement with Jeil for 'LeForte Craniomaxillofacial System' 2Bacterin Signs Distribution Agreement with Jeil for 'LeForte Craniomaxillofacial System' 3Bacterin Signs Distribution Agreement with Jeil for 'LeForte Craniomaxillofacial System' 4Candelis and Microsoft Team Up to Empower Patients 2Candelis and Microsoft Team Up to Empower Patients 3New magnetic-field-sensitive alloy could find use in novel micromechanical devices 2
MHC Volumes 1 & 2...
Vertical Rack (five box vapor phase rack), includes 2.0" (5.1cm) boxes...
... MW: 34.2kDa Formulation: 10mM HEPES, pH ... dithiothreitiol with 50% glycerol Properites: For ... Certificate of Analysis for individual lots ... followed by gel filtration and Mono-S ...
Thermal Printer Paper for Monolight(tm) Luminometer 1 each...
Biology Products: