Navigation Links
Nanoparticles can overcome drug resistance in breast cancer cells
Date:11/7/2013

Nanoparticles filled with chemotherapeutic drugs can kill drug-resistant breast cancer cells, according to a study published in the scientific journal Biomaterials.

Nanoparticles are just as small, or even smaller, than many blood proteins. They can therefore pass through the walls of healthy and sick cells, which make them interesting carriers of drugs against cancer and other diseases.

In the present study, researchers from Karolinska Institutet have shown that nanoparticles made from biodegradable plastics can overcome drug resistance in breast cancer cells. Such resistance is especially common in relapsing cancer patients and depresses, even neutralises the effect of the therapy against the tumour in many instances.

In their experiments, the researchers used breast cancer cells that responded poorly to drugs owing to their high concentrations of the enzyme microsomal glutathione S-transferase-1 (MGST-1). Abnormally high levels of MGST-1 have been associated with poor responses to several cancer drugs. The team treated the resistant breast cancer cells with nanoparticles filled with doxorubicin, a chemotherapeutic used clinically to treat bladder, lung, ovarian and breast cancer, amongst others.

"Our experiments on cultivated cells showed that the particles themselves are harmless," says research team member Dr Andreas Nystrm, Associate Professor at the Institute of Environmental Medicine, Karolinska Institutet. "We made it possible for the nanoparticles carrying the drug to kill resistant cancer cells by controlling where in the cancer cell they delivered their payload. This improved the efficacy of the drug even at a much lower dose, which is important for limiting the adverse reactions to therapy."

Nanoparticles can also be used to control where the drug is delivered in the body, and the team is now planning to equip them with targeting groups such as peptides or antibodies, that direct them to spec
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Making complex nanoparticles easily reproducible
2. Gold nanoparticles give an edge in recycling CO2
3. Stealth nanoparticles lower drug-resistant tumors defenses
4. Researchers figure out why gold nanoparticles can penetrate cell walls
5. Nanoparticles, pH phoresis could improve cancer drug delivery
6. MU researchers develop radioactive nanoparticles that target cancer cells
7. Trackable drug-filled nanoparticles -- a potential weapon against cancer
8. X-rays reveal uptake of nanoparticles by soya bean crops
9. Achilles heel: Popular drug-carrying nanoparticles get trapped in bloodstream
10. Nanoparticles reach new peaks
11. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles can overcome drug resistance in breast cancer cells
(Date:10/22/2014)... identity analyst firm Acuity Market Intelligence forecasts that in ... have a chip-based National eID card, including near-complete regional ... Asia , with its vast population, is expected ... of all National eID cards issued between 2014 and ... National eID Industry Report: 2014 Edition" — projects ...
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... for the first time how bacteria can grow directly ... the opportunity to get tremendous insights into bacteria behavior ... discovered the bacterial growth in chronic lung infections among ... by the immune cells. The researchers discovered the immune ... bacteria, forcing the bacteria to switch to a much ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
... Curabitur molestie mauris sed dolor dictum iaculis. Nulla ... in condimentum tincidunt, nisl lacus porta diam, sit amet suscipit ... consectetur adipiscing elit. Mauris est velit, iaculis scelerisque tempus semper, ... nec ut erat. Donec fringilla dapibus pharetra. Etiam vitae mi ...
... Oct. 16, 2012  Today 23andMe, the leading personal ... as Vice President Communications, Neil Rothstein as Vice ... Strategic Alliances joining the company,s executive leadership team. ... Castro is responsible for the company,s corporate communications, ...
... 17, 2012 Rising crime rates and terrorism ... monitoring and introduce reliable border control systems. These ... identification and automated immigration at all entry points, ... in the government vertical across Asia-Pacific. ...
Cached Biology News:23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions 2Increased Focus on Security Bolsters Growth of Biometrics Market in Asia-Pacific, Finds Frost & Sullivan 2Increased Focus on Security Bolsters Growth of Biometrics Market in Asia-Pacific, Finds Frost & Sullivan 3Increased Focus on Security Bolsters Growth of Biometrics Market in Asia-Pacific, Finds Frost & Sullivan 4
(Date:10/25/2014)... According to new market research report "Data Center ... Telecom), by Design Types (Electrical, Mechanical), and by ... Tier 4) - Global Forecast to 2019", published ... Construction Market into various segments with an in-depth ... also identifies the factors driving this market, various ...
(Date:10/25/2014)... The Workgroup for Electronic ... authority on the use of health IT to ... appointment of four new co-chairs to the organization’s ... ,     Peter Dumont, Senior Director – ... Leader, Deloitte Consulting LLP ,     Deidre Rodriguez, ...
(Date:10/25/2014)... October 24, 2014 Today, Nerium International, ... the winners of its “Reflect Your Youth” contest, an ... only seen a difference in their skin since using ... new outlook on life as a result of their ... as an effort by Nerium International to inspire conversations ...
(Date:10/25/2014)... 2014 A new way to produce ... of current skin grafting technologies, it also speeds up ... method, outlined in the October issue of STEM CELLS ... skin injuries that result from severe burns and chronic ... skin’s regenerative elements. These wounds heal by contraction, with ...
Breaking Biology Technology:Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3
... NEW HAVEN, Conn., Dec. 8, 2011  Cenestra Health announces ... has issued a new U.S. patent, No. 8,071,646 (the ... for highly pure formulations of eicosapentaenoic acid (EPA) and ... to about 5:1.  The ,646 patent provides exclusivity for ...
... team of scientists, led by Guillaume Gervais from McGill,s ... has engineered one of the world,s smallest electronic circuits. ... about 150 atoms or 15 nanometers (nm). This discovery, ... have a significant effect on the speed and power ...
... 2011  Fortis now offers a Bachelor of Science ... campuses – Fortis College, Cutler Bay and Fortis College, ... to students who already have a bachelor, associate or ... Fortis is now enrolling candidates who wish ...
Cached Biology Technology:Cenestra Health Announces Granting of Broad Patent Covering Proprietary Bioactive Lipid Formulations 2Cenestra Health Announces Granting of Broad Patent Covering Proprietary Bioactive Lipid Formulations 3Fortis Offers Bachelor of Science in Nursing Degree Program to Florida Students 2Fortis Offers Bachelor of Science in Nursing Degree Program to Florida Students 3
Anti-MD-2 (IN) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C...
p-Bcl-2 (Thr 74)...
Neuropilin-2 Purified Anti-Rat clone 54, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
CBF-B (G-2)...
Biology Products: