Navigation Links
Nanoparticles, 'pH phoresis' could improve cancer drug delivery
Date:7/10/2013

he researchers demonstrated that the highest degree of micelle swelling in tumors needs to occur when there is a pH of about 7.0, plus or minus 0.5, for optimal delivery of drugs to tumor tissue.

"Solid tumors have a significantly lower extracellular pH, about 6.5-6.9, compared to normal tissue, which has an average pH of 7.4," Won said.

The weak polybases in the micelles contain molecules called amines, which are made of nitrogen and hydrogen atoms. The micelles swell at lower pH due to the increased "protonation," or the addition of protons to nitrogen atoms in the amines. Because the protons are positively charged, the like-charged amines repel each other, causing the nanoparticles to expand.

The positive charge slows the movement of micelles out of tumor tissue, which would cause the nanoparticles to accumulate inside the tumor mass long enough to enter tumor cells and release anticancer drugs.

"This concept is straightforward to understand, yet no one recognized it previously," Won said. "And it took us a while to put this description on a mathematical footing. To do that, we had to modify the famous Fick's first law diffusion equation."

The law, derived by physician and physiologist Adolf Fick in 1855, describes how molecules diffuse from regions of high concentration to regions of low concentration.

The micelles also are coated with protective varnish so that they might remain intact long enough to reach tumor sites, where they would expand and then biodegrade.

More research is needed to determine how well the approach could enhance drug delivery, but the pH phoresis concept developed by Won and his student represents a step in developing nanomedicine techniques in drug delivery, he said.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Heart-powered pacemaker could one day eliminate battery-replacement surgery
2. New test could help track down and prosecute terrorists
3. New antibiotic could make food safer and cows healthier
4. BPA could affect reproductive capabilities, cause infection of the uterus
5. Key to immune system disease could lie inside the cheek
6. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
7. Tiny electrical sensors could signal faster MRSA diagnosis
8. Corals could survive a more acidic ocean
9. Early warning system for seizures could cut false alarms
10. Rapid method of assembling new gene-editing tool could revolutionize genetic research
11. 800-year-old farmers could teach us how to protect the Amazon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... Ark. , Feb. 25, 2015  ABC ... and billing in the Health and Fitness Industry, ... well as to MYiCLUBonline.  The latest upgrade includes ... the inclusion of cardless check-in via Identity One ... the first time through interactive displays at the ...
(Date:2/24/2015)... Feb. 24, 2015 This report analyzes the worldwide markets ... Segments: Face Biometrics, and Voice Biometrics. The report provides separate comprehensive ... Japan , Europe , Asia-Pacific ... Africa , and Latin America . Annual ... Also, a seven-year historic analysis is provided for these markets. Market ...
(Date:2/23/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announced today ... DISTRIBUTED VOICE DIRECTED PAYMENT METHOD AND SYSTEM. ... payment method. Payment accounts may be selected via voice ... if both the speech (the word associated with the ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
... Italy and their offspring form one of the largest demographic ... state of health and risk of mortality. In a first ... of Zurich,s Institute of Social and Preventative Medicine calculated unbiased ... Immigrants from Italy live longer than Swiss ...
... health experts point to an increased need for exercise, more ... States have dropped physical education requirements compared to historic levels. ... physical education and exercise requirements in the 1920s; today, that ... to a new study. Oregon State University researcher ...
... PA (January 7, 2013) The PATH Malaria Vaccine ... INO) today announced a follow-on collaboration to advance ... Researchers will test whether a novel vaccine approach ... vaccine delivery technology called electroporation could induce an ...
Cached Biology News:Italian immigrants live longer 2Physical education requirement at 4-year universities at all-time low 2Physical education requirement at 4-year universities at all-time low 3MVI and Inovio partner to develop malaria vaccines using innovative vaccine delivery tech 2MVI and Inovio partner to develop malaria vaccines using innovative vaccine delivery tech 3
(Date:3/3/2015)... Crown Bioscience, Inc., a leading global drug ... Life Science division specializing in in vivo and in ... first products released include in vivo grade human and ... released in vivo grade monoclonal antibodies against PD-L1 and ... science portfolio with additional antibody products as well as ...
(Date:3/3/2015)... Milpitas, Calif. (PRWEB) March 03, 2015 ... risk management excellence were honored by the Global ... annual event which took place on Wednesday, February 25th, ... , The GSCRC was formed to bring together supply ... thought leaders to advance the professional discipline through opportunities ...
(Date:3/3/2015)... 3, 2015  Thingee Corporation, a software development company ... presentation entitled, "Technology Adoption: Making Reps, Lives Easier" during ... and Technology ,  in Deerfield Beach, Florida ... 2015. Audiences looking to learn how technology can help ... be in the audience for the Thingee presentation. ...
(Date:3/3/2015)... SAN FRANCISCO , March 3, 2015 Kindred ... focused on saving and improving the lives of pets, announced ... 2014 financial results on March 12, 2015 after the market ... p.m. Eastern Time that day. Interested parties ... the US, or (484) 756-4262 internationally, and using conference ID ...
Breaking Biology Technology:Crown Bioscience Launches Life Science Product Catalog 2Global Supply Chain Resiliency Council Names Award Winners 2Global Supply Chain Resiliency Council Names Award Winners 3Global Supply Chain Resiliency Council Names Award Winners 4Thingee to present at 11th Annual Synergistix Users Conference 2
... Inc. (Nasdaq: ATSI ), manufacturer and marketer ... participation in the upcoming 89th Annual Meeting of the ... Boston from May 10-13, 2009. The Annual AATS ... allied health professionals from around the world that provides ...
... 2009) launches Cloe(R) Gateway, a new secure web portal ... Cloe(R) Gateway is a new,enhanced version of our proprietary ... simple in vitro ADME and,physicochemical properties. , ... Baxter, Cyprotex,s Chief,Executive Officer, said: , ...
... Amgen (Nasdaq: AMGN ), today announced ... Stockholders, held at The St. Regis Hotel, San Francisco, ... represented at the meeting.The director nominees: David Baltimore, Frank ... Vance D. Coffman, Frederick W. Gluck, Frank C. Herringer, ...
Cached Biology Technology:ATS Medical Announces Participation in the Annual Meeting of the American Association for Thoracic Surgeons 2ATS Medical Announces Participation in the Annual Meeting of the American Association for Thoracic Surgeons 3ATS Medical Announces Participation in the Annual Meeting of the American Association for Thoracic Surgeons 4Cyprotex Launches Cloe(R) Gateway, its Secure web Portal for Access to Cyprotex Services Including an Enhanced Version of Cloe(R) PK. 2Amgen Announces Voting Results Of Annual Meeting Of Stockholders 2
... acquision and analysis software for ... applications. Contains powerful stimulus generation ... functions including automated waveform feature ... includes many electrophysiology specific functions ...
EDG-6 Lysate Source: Cell Lysate Application: Western Blotting Control Form: IgG...
Madin-Darby bovine kidney (MDBK) cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Peptide-affinity Purified Polyclonal Antibody to Olfactory Receptor, Family 2, Subfamily H, Member 3...
Biology Products: