Navigation Links
NYU Langone researchers identify a signaling pathway as possible target for cancer treatment
Date:8/15/2011

In a new study published in the August 16th issue of Developmental Cell, researchers at NYU Langone Medical Center identified a molecular mechanism that guarantees that new blood vessels form in the right place and with the proper abundance.

"We have known for a long time that blood vessels branch to give rise to new ones and that in some places of our bodies this branching occurs with a reproducible pattern. However, the mechanisms that ensure that new vessels sprout at specific locations had not been uncovered until now," said Jess Torres-Vzquez, PhD, assistant professor of Developmental Genetics at the Skirball Institute of Biomolecular Medicine at NYU School of Medicine. "Our study illuminates the genetic basis behind the reproducible pattern of the vasculature and suggests ways in which the formation of new blood vessels could be modulated to treat certain cancers in the future."

Using the zebrafish embryo as a model system, researchers identified that Semaphorin-PlexinD1 signaling limits the formation of new blood vessels. This signaling pathway works by ensuring that blood vessels make the proper levels of soluble Flt1. Soluble Flt1 is an inhibitor of the Vascular Endothelial Growth Factor (VEGF) pathway, which promotes the growth of new blood vessels.

These findings have broad implications for human health, since changes in the level of soluble Flt1 are associated with cancer, vascular birth defects and pregnancy-related hypertension (preeclampsia).

According to researchers, the Semaphorin-PlexinD1 signaling pathway shows significant promise as a future therapeutic target for cancer treatment to slow the progression of diseases by controlling the blood vessel growth.


'/>"/>

Contact: Christopher Rucas
christopher.rucas@nyumc.org
212-404-3525
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
2. NYU Langone experts present advances at American Association of Neurological Surgeons Meeting
3. NYU Langone Medical Center receives $5.4 million NYSTEM grant for stem cell research
4. NYU Langone Medical Center awarded NIH grants totaling $1,560,000
5. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
6. Toronto researchers first to discover new genetic clue in the development of rheumatoid arthritis
7. Researchers decode workings of mysterious, but critical TB drug
8. Researchers fight cholera with computer forecasting
9. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
10. Narcissism may benefit the young, researchers report; but older adults? Not so much
11. York U researchers zero in on protein that may help treat obesity, diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/14/2020)... ... 14, 2020 , ... Trial By Fire Solutions, a leader ... tracking, will be showcasing SimpleTrials at the Summit For Clinical Ops Executives (SCOPE) ... last year, the SimpleTrials team has completed full validation of the system and ...
(Date:2/13/2020)... ... 13, 2020 , ... Pharmica Consulting announced it will attend ... focusing on all facets of clinical trial planning and management. Pharmica will be ... , “We have attended the SCOPE Summit every year and are excited ...
(Date:2/11/2020)... KING OF PRUSSIA, Pa. (PRWEB) , ... ... ... Tunnell Consulting, an organization dedicated to solving complex problems for life sciences ... Principal. Horn brings over 30 years of management consulting expertise to Tunnell, ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular diagnostics company ... the 11-locus, single tube multiplex successor to Holotype HLA is available through an ... and short library preparation, for HLA genotyping from sample to answer in less ...
(Date:1/28/2020)... WASHINGTON (PRWEB) , ... January ... ... provider of enterprise software solutions for biopharmaceutical R&D, today announced the release ... release reinforces Genedata’s focus on supporting the implementation of Multi-Attribute Methods (MAM) ...
(Date:1/27/2020)... ... January 27, 2020 , ... Cerebyte, the leader in “instant ... today announced the availability of neuroscience of transformational leadership workshops. These highly interactive, ... of leadership and change research to become great transformational leaders. The workshops ...
(Date:1/24/2020)... ... , ... The plastic and reconstructive surgeons at The Institute for Advanced ... that plastic surgery is much more than just cosmetic surgery and far more extensive ... 20 years NJ Top Docs, Dr. Andrew Elkwood, Dr. Michael Rose, Dr. Matthew Kaufman, ...
Breaking Biology Technology: