Navigation Links
NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
Date:1/21/2010

NEW YORK, NY (January 21) - New York Stem Cell Foundation (NYSCF)-Druckenmiller Fellow, Daylon James, PhD, of Weill Cornell Medial College, is lead author on a study defining conditions for generating a plentiful supply of endothelial (vessel lining) cells that are suitable for therapeutic use. Dr. James and his colleagues created a human embryonic stem cell (hESC) "reporter" line that can be used to measure endothelial cell production and activity.

The study, Expansion and maintenance of human embryonic stem cellderived endothelial cells by TGFβ inhibition is Id1 dependent, was published in the online edition of Nature Biotechnology on January 17th, 2010, and will also appear in the journal's print edition. In addition to Dr. James, whose work is funded by NYSCF, contributors to the study also included NYSCF-Druckenmiller Fellows, Drs. Gabsang Lee and Marco Seandel.

Using the reporter line, Dr. James and his colleagues were able to monitor the emergence of endothelial cells in live cultures, and screen for small bioactive molecules that increased their yield. By this method, they were able to indentify a compound that robustly increased the amount of endothelial cells produced. This work establishes a standard methodology for generating functional endothelial cells from hESCs using conditions that are suited to clinical application. These cells can now be routinely and economically produced on scales that make pre-clinical assessment of their efficacy practical in large animal models of vascular disease.

"We are very proud of Dr. James. These findings bring us closer to having functional endothelial cells available for studying vascular disease," says Susan L. Solomon, NYSCF's founder and CEO.

As advancements in induced pluripotent stem (iPS) cell technology continue, hESC research like that of Dr. James is essential for the field of stem cell research. Embryonic stem cells are still the gold standard for monitoring pluripotency and differentiation capabilities.

"It is research like this that brings us closer to cures for the major diseases of our time," said Dr. Kevin Eggan, Chief Scientific Officer of NYSCF. "Daylon is one of the premier young scientists in the field of stem cell research and we are excited to have him in our fellowship program."


'/>"/>

Contact: Ruth Jarmul
rjarmul@nyscf.org
212-787-4111
New York Stem Cell Foundation
Source:Eurekalert

Related biology news :

1. IGERT fellows to design biodevices using flexible electronics
2. ASPB announces Summer Undergraduate Research Fellowship 2007 recipients
3. UC Riverside biologist receives prestigious MacArthur Fellowship
4. Entomological Society of America recognizes 2007 fellows and honorary members
5. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young investigators
6. Pew Institute for Ocean Science awards 5 fellowships in support of global marine conservation
7. 2008 Pew Fellowship in marine conservation awarded to UM Rosenstiels Dr. Andrew Baker
8. Dr. Andrew Constable awarded 2008 Pew Fellowship in marine conservation
9. 2008 Pew Fellowship in Marine Conservation awarded to Dr. Ussif Rashid Sumaila
10. 2008 Pew Fellowship in Marine Conservation awarded to Fan Meng; first Chinese fellow
11. 2008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)...  Aware, Inc. (NASDAQ: AWRE), a leading supplier of ... Moberg has resigned, effective March 3, 2017, as ... and Treasurer of Aware citing a desire to retire.  ... of the Board of Directors of Aware. ... and co-President, General Counsel has been named Chief Executive ...
(Date:2/28/2017)... Februar 2017  EyeLock LLC, ein marktführendes Unternehmen im ... biometrische Lösung zur Iris-Erkennung auf der neuesten ... auf dem Mobile World Congress 2017 (27. ... Halle 3, Stand 3E10, vorstellen. ... Haven™ – eine Kombination aus Hardware, Software ...
(Date:2/24/2017)... Feb. 24, 2017  EyeLock LLC, a leader of iris-based ... iris biometric solution on the latest Qualcomm® Snapdragon™ ... Mobile World Congress 2017 (February 27 – ... Hall 3, Stand 3E10. The ... security platform—a combination of hardware, software and ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... March 30, 2017 Personal Genome Diagnostics Inc. (PGDx) ... upcoming American Association for Cancer Research (AACR) Annual Meeting 2017, ... , D.C.  The company also announced that five scientists associated ... 11 th Annual AACR Team Science Award. ... Doug Ward ...
(Date:3/29/2017)... 29, 2017 QIAGEN N.V. (NASDAQ: QGEN ; ... U.S. launch of its ipsogen ® JAK2 RGQ PCR Kit ... Drug Administration as a qualitative in vitro diagnostic test for the detection of ... ... on QIAGEN,s Rotor-Gene ® Q MDx system, which is a member of ...
(Date:3/29/2017)... Addison, Tx (PRWEB) , ... March 29, 2017 ... ... is honored to announce that Nerium International Mexico has been approved as an ... AMVD works to achieve satisfaction and protection among distributers and consumers in relationship ...
(Date:3/29/2017)... ... March 29, 2017 , ... ACEA Biosciences, a privately ... quarterly travel award to noteworthy scientists who will be presenting research using ACEA ... round of awards are being given to two postdoctoral fellows studying pathogen capture ...
Breaking Biology Technology: